Adjuvant Vitamin C in critically ill patients undergoing renal replacement therapy: What’s the right dose?
Keywordsvitamin C pharmacokinetics dialysis continuous renal replacement therapy
Vitamin C trough and peak levels stratified by renal funcion
Vitamin C -trough (umol/l)
Vitamin C- peak (umol/l)
No AKI (n = 5)
0.56 ± 0.25
224 ± 121
543 ± 276
AKI + CRRT (n = 4)
1.3 ± 1.1
263 ± 129
461 ± 194
CRF + Intermittent HD (n = 3)
4.6 ± 3.1
346 ± 126
914 ± 205
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PEM drafted the original version of the manuscript. MHH reviewed and revised the manuscript. Both authors have reviewed the final version of the manuscript and approve the manuscript for publication.
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