Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients
Intensive care unit
Biomarkers represent an essential tool for identification of patients developing infection and to determine their clinical severity. Procalcitonin (PCT) levels appeared to be correlated with the development of severe bacterial infections . Thus, PCT systematic use has been proposed as part of the diagnostic tools and for monitoring treatment duration [2, 3], but not all of the potential benefits and limitations of PCT have been investigated.
Our data confirmed the previous observations about the role of PCT and CRP in predicting BC results in critically ill patients [4, 5]. Of interest, CRP was not able to predict BC results, whereas PCT values correlated with GN bacteremia and, among them, specifically identified Enterobacteriaceae. High PCT values (> 10 ng/mL) were independently associated with Enterobacteriaceae isolation. Even with the limitation of a single-center experience, these results might be useful to determine another role for PCT, helping physicians in the rapid identification of bacteremic ICU patients at risk of GN infection (especially Enterobacteriaceae) and driving the choice of a more appropriate empirical therapy.
Availability of data and materials
Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.
MB, AR, ER, ED, and MM carried out the data collection and drafted the manuscript. NC, FD, AS, and FC participated in the design of the study and performed the statistical analysis. All authors read and approved the final manuscript.
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Approved by local ethics review committee.
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The authors declare that they have no competing interests.
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- 5.Oussalah A, Ferrand J, Filhine-Tresarrieu P, Aissa N, Aimone-Gastin I, Namour F, et al. Diagnostic Accuracy of Procalcitonin for Predicting Blood Culture Results in Patients With Suspected Bloodstream Infection: An Observational Study of 35,343 Consecutive Patients (A STROBE-Compliant Article). Medicine (Baltimore). 2015;94:e1774.CrossRefGoogle Scholar
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