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Journal of Ovarian Research

, 12:11 | Cite as

Correction to: Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system

  • Kaijian Ling
  • Lupin Jiang
  • Shi Liang
  • Joseph Kwong
  • Leiyan Yang
  • Yudi Li
  • PingYin
  • Qingchun DengEmail author
  • Zhiqing LiangEmail author
Open Access
Correction
  • 54 Downloads

Correction to: J Ovarian Res (2018) 11:36

https://doi.org/10.1186/s13048-018-0403-2

The original article [1] contains errors in Figs. 6 and 8. The corrected figures can be shown ahead.
Fig. 6

Migratory tendency of GFP (+)/GFP (−) cells when treated with different hormone drugs. a and b) The number of migratory cells increased in the DHT groups of the A2780 + 20 and SKOV3 + 5 GFP (+)/GFP (−) cell lines. c and d) Notably, when treated with DHT, the number of GFP (+) migratory cells increased markedly compared with DMSO or DHT + ASC-J9; e and f) The number of migratory in A2780 + 20 and SKOV3 + 5 Nanog GFP (+) cells were also higher than that of the Nanog GFP (−) cells. For analysis, the cells number in four fields was calculated at 40× magnification. Bar: 100 μM. DHT: 10 nM, and ASC-J9: 5 μM. **P < 0.01; ***P < 0.001

Fig. 8

AR signaling axis enhances the stemness characteristics of ovarian cancer cells. a) Sphere formation assays of the monoclonal GFP (+)/GFP (−) cells of the SKPV3 + 5 and A2780 + 20 cell lines. The sphere formation abilities of the GFP (+) cell lines were significantly stronger than those of the GFP (−) cell lines. Bar: 200 μM. b) Colony formation assays of the monoclonal GFP (+)/GFP (−) cells of the SKPV3 + 5 and A2780 + 20 cell lines. The clonal efficiency of the GFP (+) cells was higher than that of the GFP (−) cells. Bar: 200 μM. c and d) Androgen or inhibitor treatment in SKPV3 + 5 and A2780 + 20 GFP (+) cells. Sphere and colony formation were enhanced when DHT was added, while ASC-J9 decreased this effect. DMSO was used as the vehicle control. DHT: 10 nM, and ASC-J9: 5 μM; Bar: 100 μM. *P < 0.05, **P < 0.01, and ***P < 0.001

Reference

  1. 1.
    Ling K, Jiang L, Liang S, et al. Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system. J Ovarian Res. 2018;11:36  https://doi.org/10.1186/s13048-018-0403-2.CrossRefGoogle Scholar

Copyright information

© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors and Affiliations

  • Kaijian Ling
    • 1
  • Lupin Jiang
    • 1
  • Shi Liang
    • 2
  • Joseph Kwong
    • 3
  • Leiyan Yang
    • 1
  • Yudi Li
    • 1
  • PingYin
    • 1
  • Qingchun Deng
    • 1
    Email author
  • Zhiqing Liang
    • 1
    Email author
  1. 1.Department of Obstetrics & Gynecology, Southwest HospitalThird Military Medical UniversityChongqingChina
  2. 2.Bjrigham Young UniversityRexburgUSA
  3. 3.Department of Obstetrics & Gynaecology Faculty of Medicine, Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina

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