Correction to: Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy

  • Longwen Xu
  • Zhiyuan Cheng
  • Chuanliang Cui
  • Xiaowen Wu
  • Huan Yu
  • Jun GuoEmail author
  • Yan KongEmail author
Open Access

Correction to: J Transl Med (2019) 17:245

Following publication of the original article [1], the authors reported errors in Figures 2, 3 and Figure 3 ‘continued’.
  1. 1.

    In Figure 2b and 2f of PDX2 model, duplicated pictures of tumors have been used.

  2. 2.

    In Figure 3 of H&E staining of PDX-004, duplicated pictures have been used. Moreover, the description of the second PDX-001 was not correct in Figure 3.

  3. 3.

    In Figure 3 ‘continued’ of H&E staining, duplicated pictures have been used in all PDX groups. Moreover, the part labels in Figure 3 ‘continued’ were not correct.

In this Correction the corrected version of Figs. 2, 3 and Fig. 3 ‘continued’ are shown.
Fig. 2

Sensitivity of PDX models containing CDK4 aberrations to CDK4/6 inhibitors in vivo. When the tumor size reached approximately 600 mm3, mice (n = 4 per group) were treated with buffer control or inhibitors daily. Tumor volume was evaluated as % of the tumor volume on day 0 and presented as mean ± SD. The comparison of the growth curves was done with the repeated measure variance analysis. ns no significances; **P < 0.01; ***P < 0.001

Fig. 3

Proliferation index of mucosal melanoma cells from PDX models containing CDK4 aberrations after CDK4/6 inhibitors treatments. On day 14 of treatments, the tumor nodules were excised and examined by H&E staining and immunohistochemical staining (for Ki-67). The sections were evaluated under microscope, and typical staining was photographed (a). The Ki-67 + cells under 5 random fields were counted. Bar = 20 μm. The results of Ki-67 + cells (bf) were presented as mean ± SD of three sections. ns no significances; *P < 0.05; **P < 0.01; ***P < 0.001



  1. 1.
    Xu L, Cheng Z, Cui C, Wu X, Yu H, Guo J, Kong Y. Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy. J Transl Med. 2019;17:245. Scholar

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Authors and Affiliations

  1. 1.Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and MelanomaPeking University Cancer Hospital & InstituteBeijingChina

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