Survival of HIV infected patients on maintenance hemodialysis in Cameroon: a comparative study
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Abstract
Background
There are conflicting reports on the impact of HIV in the era of combined antiretroviral (c-ART) on survival of patient with ESKD. We aimed to compare the one-year survival of HIV positive patients to that of their HIV negative counterparts with ESKD on maintenance haemodialysis in Cameroon.
Methods
This was a retrospective cohort study conducted in the haemodialysis units of the Douala and Yaoundé General Hospitals. All HIV positive patients treated by maintenance haemodialysis between January 2007 and March 2015 were included. A comparative group of HIV negative patients with ESKD were matched for age, sex, co morbidities, year of dialysis initiation and haemodialysis unit. Relevant data at the time of haemodialysis initiation and during the first year of haemodialysis was noted. Survival was analysed using the Kaplan Meier and Cox regression hazard ratio estimator. A p value < 0.05 was considered statistically significant.
Results
A total of 57 patients with HIV and 57 without HIV were included. Mean age was 46.25 ± 11.41 years, and 52.6% were females in both groups. HIV nephropathy (50.9%) was the main presumed aetiology of ESKD in the HIV group, while chronic glomerulonephritis (33.3%) and diabetes (21.1%) were the main aetiologies in the HIV negative group. At initiation of dialysis, the median CD4 count was 212 cell/mm3 (IQR; 138–455) and 77.2% were receiving c-ART. The proportion of patients who initiated dialysis with a temporary venous catheter was similar in both groups (p = 0.06). After one year on haemodialysis, survival rate was lower in the HIV positive group compared to the HIV negative group (61.4%/78.9%, HR: 2.05; 95% CI: 1.03–4.08; p = 0.042).Kaplan Meier survival curve was in direction of a lower survival in HIV positive group (p = 0.052).
Conclusion
The one year survival of HIV positive patients on maintenance haemodialysis in Cameroon seems to be lower compared to their HIV negative counterparts.
Keywords
HIV patients End stage kidney disease Haemodialysis Survival CameroonAbbreviations
- c-ART
combined Antiretroviral Treatment
- CKD
Chronic Kidney Disease
- ESKD
End stage Kidney Disease
- HIV
Human Immune depressive Virus
- HIVAN
HIV Associated Nephropathy.
- RRT
Renal Replacement Therapy
- SSA
sub Saharan Africa
Background
Despite significant progress in the past two decades, human immune deficiency virus (HIV) infection remains a major cause of death and disease burden worldwide. In 2015, about 38.8 million people were HIV positive with 75% of them living in Sub-Saharan Africa (SSA) [1]. Chronic kidney disease (CKD) a common complication of HIV infection is associated with increased morbidity and mortality [2, 3]. Due to predisposing genetics polymorphism in the myosin heavy chain 9 and Apo lipoprotein L1 genes, black people have a 3 to 6 fold higher risk of HIV related renal diseases than white [4, 5, 6, 7, 8] and HIV- associated nephropathy (HIVAN) is the 3th leading cause of end stage kidney disease (ESKD) amongst black in the United States of America [9]. Impaired renal function has also been identified as a risk factor for death in the general and in HIV-infected populations [2, 10, 11]. The prognosis of HIV patients with ESKD was very poor and access to dialysis for these patients was limited in some countries before the introduction of combined antiretroviral treatment (c-ART) [12]. The poor outcome was mainly dependent on the severity of the HIV infection [10, 12, 13, 14].
C- ART is based on the association of three anti-viral drugs that inhibit the HIV replication. It was introduced in the care of HIV patients in 1997 and has improved the survival of these patients on renal replacement therapy (RRT) [15]. Reported results on survival of HIV positive patients compared to HIV negative one on haemodialysis are conflicting. In the USA survival of HIV patients with ESKD was lower compared to HIV negative patients [10, 16], while 2-year survival of treated HIV positive patients on haemodialysis was comparable to HIV-negative ones in France [17]. Despite the burden of HIV and the improve access to RRT and c-ART in most countries in sub Saharan Africa (SSA), data on survival of HIV patients on RRT are rare. A recent study in South Africa reported a similar survival between HIV positive and negative patients [18].
HIV infection is endemic in Cameroon with a population prevalence of 4.3% [19]. Access to c-ART is free and HIV does not constitute a contraindication to RRT. In Cameroon, about 8 to 10.8% of the haemodialysis population is HIV positive [20, 21]. Outcomes of patients on maintenance haemodialysis in Cameroon remain very poor [22, 23]. The impact of HIV positivity on patient outcomes on maintenance haemodialysis is unknown. This comparative study aimed to determine the survival of HIV infected patients with ESKD on maintenance haemodialysis in Cameroon.
Methods
Study setting
This was a retrospective cohort study carried out from January to Mars 2016 in the haemodialysis unit of the Douala and Yaoundé general hospitals, the two main tertiary hospital of the country. They are the referral hospitals for patients with kidney diseases of the littoral and centre region of the country. Both haemodialysis units are equipped with Fresenius® HD 4008S generators (Fresenius Medical Care, Hamburg, Germany), used synthetic polysulfone dialysis membrane and bicarbonate dialysate. No dialyzer reuse is practiced. The majority of patients underwent 2 dialysis sessions of 4 h per week. In Cameroon dialysis and c-ART is highly subsidized by the state and access to the treatment is not limited. HIV patients with ESKD are followed up by internist - nephrologist with a special training in management of HIV related diseases. The study received administrative authorization from the Douala and Yaoundé general hospital and ethical approval was obtained from the Douala University Ethics Committee.
Patients
We included HIV infected patients who started maintenance haemodialysis between first January 2007 and 31th March 2015 in both hospitals. HIV patients with missing relevant data were excluded. A group of HIV-negative patients was then selected as matching controls and they were paired in a 1:1 ratio according to age, sex, date of dialysis initiation, and centre of dialysis. From medical records data collected initially were: socio demographic (age, sex, marital status), clinical (co morbidity, baseline nephropathy, vascular access and use of c-ART at dialysis initiation), para clinical (haemoglobin level, CD4 count, serum calcium and phosphorus level at dialysis initiation). While on dialysis we recorded opportunistic infections, outcome at one year (death, withdrawal or alive) and causes of death.
The clinical stage of HIV infection was based on the WHO classification [24]. ESKD was defined as initiation of chronic RRT for more than 3 months. The background nephropathy was mainly based on clinical arguments in the absence of renal histology data. Hypertension was defined as a blood pressure > 140/90mmhg or evidence from patient records that the patient was receiving antihypertensive treatment.
Statistical analysis
Analysis was performed with Statistical Package for Social Science (SPSS) version 20.0. Categorical variables were reported as frequency and percentages and compared with Chi-square test or Fisher’s exact test when appropriated. Continuous variables were reported as mean ± standard deviation (SD) and median and inter quartile range (IQR) and their comparisons were done respectively by Student t-test and Mann Whitney U test. Survival analysis was done using the Kaplan Meier method (log rank test).ß probability of type II error was computed for borderline p value. Cox proportional hazard regression models were used to determine predictors of death. Basic models were adjusted for age, and then final models were further adjusted for age and all predictors with a p value < 0.1 in the basic models (diabetes, absence of c-ART at dialysis initiation). A p value < 0.05 was considered statistically significant.
Results
Baseline characteristic of the study population (n = 114)
| Variables | HIV- N = 57 | HIV + N = 57 | p | |
|---|---|---|---|---|
| Gender n (%) | ||||
| Female | 30 (52.6) | 30 (52.6) | ||
| Male | 27 (47.4) | 27 (47.4) | 1 | |
| Age (years) | Mean ± SDa | 46.25 ± 11.41 | 46.00 ± 11.40 | 0.909 |
| Matrimonial status n (%) | ||||
| Married | 42 (73.7) | 27 (47.4) | ||
| Non married | 15 (26.3) | 30 (52.6) | 0.004 | |
| Co morbidity n (%) | ||||
| History of hypertension | 51 (89.5) | 35 (61.4) | < 0.001 | |
| History of diabetes | 15 (26.3) | 9 (15.8) | 0.168 | |
| Hepatitis B infection | 3 (5.3) | 4 (7.0) | 1 | |
| Hepatitis C infection | 8 (14.0) | 8 (14.0) | 1 | |
| Baseline nephropathy | ||||
| HIVb | 0 (0.0) | 29 (50.9) | ||
| CGNc | 19 (33.3) | 8 (14.0) | ||
| Unknown | 11 (19.3) | 11 (19.3) | ||
| Hypertension | 15 (26.3) | 7 (12.3) | ||
| Diabetes | 12 (21.1) | 2 (3.5) | < 0.001 | |
| Vascular access at initiation n (%) | ||||
| Temporary CVCd | 45 (78.9) | 52 (91.2) | ||
| AVFe | 12 (21.1) | 5 (8.8) | 0.066 | |
| Biologic Data | Mean ± SDa | |||
| Haemoglobin | 7.86 ± 1.98 | 7.12 ± 1.70 | 0.045 | |
| Calcemia | 76.59 ± 14.78 | 73.64 ± 16.78 | 0.370 | |
| Phosphoremia | 71.13 ± 28.84 | 67.88 ± 35.47 | 0.639 | |
| CD4 count n = 49 | ||||
| Median (IQRf) | 212 (138–455) | – | – | |
| CD4 count<200cells/mm3 n (%) | 23 (46.9) | – | – | |
| Use of c-ARTg n (%) | 44 (77.2) | – | – | |
| Drug regimen n (%)(n = 44) | – | – | ||
| 1st line | 37 (84.1) | – | – | |
| 2nd line | 6 (13.6) | – | – | |
| Hospitalisation rate n (%) | 10 (17.5) | 12 (21.1) | 0.635 | |
Mortality and survival rate
| All patients N = 114 n (%) | HIV- N = 57 n (%) | HIV+ N = 57 n (%) | HRa (95% CIb) | p value | |
|---|---|---|---|---|---|
| Mortality rate | 34 (29.8) | 12 (21.1) | 22 (38.6) | 2.05 (1.03–4.08) | 0.042 |
Kaplan Meier Survival curve; p value = 0.052 for log rank test, ß probability = 0.84
Presumed causes of death
| Causes of death | All patients N = 34 n (%) | HIV- N = 12 n (%) | HIV+ N = 22 n (%) | p value |
|---|---|---|---|---|
| Sepsis | 14 (41.2) | 6 (50.0) | 8 (36.4) | 0.440 |
| Tuberculosis | 4 (11.8) | 0 (0.0) | 4 (18.2) | 0.273 |
| Withdrawal from Dialysis | 4 (11.8) | 0 (0.0) | 4 (18.2) | 0.273 |
| Gastro intestinal bleeding | 4 (11.8) | 3 (25.0) | 1 (4.5) | 0.115 |
| Hemorrragic stroke | 1 (2.9) | 0 (0.0) | 1 (4.5) | 1 |
| Pulmonary edema | 1(2.9) | 0(0.0) | 1(4.5) | 1 |
| Cancer of the kidney | 1(2.9) | 0(0.0) | 1(4.5) | 1 |
| Undetermined | 5 (14.7) | 3 (25.0) | 2(9.0) | 0.677 |
Predictors of death amongst HIV positive patients (Cox regression analysis)
| Variable | Basic models | Final models | ||
|---|---|---|---|---|
| HRa (95% CIb) | p | HRa (95% CI) | p | |
| Age | 1.02 (0.98–1.06) | 0.284 | 1.02 (0.98–1.06) | 0.452 |
| Gender (female vs male) | 1.00 (0.40–2.52) | 0.993 | 1.09 (0.44–2.72) | 0.857 |
| Unemployed | 1.24 (0.53–2.89) | 0.619 | 1.95 (0.76–4.97) | 0.165 |
| Absence of nephrology follow up before 1st dialysis | 1.14 (0.49–2.65) | 0.757 | 0.93 (0.39–2.19) | 0.863 |
| Dialysis initiation with a temporary catheter | 2.30 (0.31–17.09) | 0.417 | 3.31 (0.42–25.94) | 0.254 |
| Hypertension | 1.03 (0.43–2.48) | 0.949 | 0.89 (0.33–2.42) | 0.825 |
| Diabetes | 2.32 (0.87–6.19) | 0.094 | 1.76 (0.64–4.85) | 0.271 |
| Hepatitis B | 0.52 (0.07–3.90) | 0.528 | 0.21 (0.03–1.81) | 0.156 |
| Hepatitis C | 1.39 (0.44–4.39) | 0.572 | 1.40 (0.43–4.61) | 0.579 |
| No cARTc at dialysis initiation | 2.99 (1.27–7.06) | 0.012 | 2.66 (1.09–6.50) | 0.031 |
Discussion
This study aimed to evaluate for the first time the outcome of HIV infected patients on maintenance haemodialysis compared to HIV negative ones in a setting where c-ART is free and access to dialysis not limited. Our results showed that HIV positive patients on haemodialysis were relatively young adults, severely immune depressed. After one year on dialysis survival rate of HIV positive patients was lower compared to negative one, with a twofold higher risk of death. Survival curve was in direction of a lower survival in HIV group with a borderline p value and a high ß probability of type II error.
The number of people living with HIV/AIDS has steadily increase, with greatest prevalence and mortality rate in SSA [1]. In Cameroon HIV and ESKD are public health problem, and ESKD due to HIV remain a serious concern [18, 19, 20, 21]. Combined ART is freely available since 2007. Haemodialysis, the only RRT available is subsidized to 95% by the State and access is not limited for HIV patients as it is the case in some SSA countries [25, 26]. The present study revealed that HIV patients on haemodialysis were relatively young mostly female and were severely immune compromised at the start of haemodialysis. This in accordance with others reported findings in the literature [27].
Haemodialysis and HIV infection are two risks factors that exposed HIV patients on maintenance haemodialysis to death [10]. The widespread of c-ART has improved the outcome of HIV positive patients worldwide [15, 19, 28, 29]. Survival of these patients with ESKD receiving RRT, has also progressively improved [15, 30]. Data on survival of HIV positive patients on RRT in SSA are scanty and inexistent in Cameroon. We found that one year survival rate of HIV positive patient was 61.4%. Our survival rate of HIV patients is lower than reported findings in the international literature that range from 74 to 95.2% in HIV positive patient receiving haemodialysis [10, 17, 18, 31, 32, 33]. In the USA one year survival of HIV-positive patients receiving chronic haemodialysis was estimated at 74% [10, 31]. In the study of Tourret et al. and Trullas et al. in Europe survival rate was 93.8 and 95.2% respectively [17, 32]. Tayebey et al. in Iran, found a rate of 75% [33], and Fabian et al. in South Africa recently reported a 100% survival rate of HIV-positive patients [18]. In the contrary our survival rate is higher compared to the studies of Zako et al. in South Africa (51%) [34] and Rodriguez et al. (46%) [31].
Reported results on survival of HIV positive patients compared to HIV negative one on haemodialysis are conflicting [6, 10, 17, 18]. In the present study, at one year survival rate of HIV infected patient was lower compared to HIV negative (p value 0.042) with a twofold risk of death in HIV positive patients. The Kaplan Meier curve was in direction of a worse survival curve in the HIV positive group, with a borderline p value (0.052) and a high beta probability of type II error probably due to the small sample size of our study population (57 patients) and the short duration of follow up (one year). This lower survival of HIV patients compared to negative one was also reported by Ramon et al. in Spain and Martinez et al. in Italy and in the USA. [10, 16, 35, 36] In the contrary our result is different from the reports of Tourret et al. in France [17] and Fabian et al. in South Africa [18] who found a similar survival between HIV-positive and HIV-negative patient.
The main predictor of death amongst our HIV patients was the absence of c-ART at dialysis initiation. Survival of HIV positive patients on haemodialysis has been shown to be correlated with earlier stage of the infection, younger age, higher CD4 counts, and treatment with c-ART [10, 12, 16, 37, 38]. Despite that our patients were young, and compared to the international literature our lower survival rate can be explain by the fact that patients were at late stage of the disease with severe immune depression (46.9% had CD4 count < 200 cell/mm3) and 1/4 of them were not on c-ART at dialysis initiation due to late referral of patients, a common situation in our setting [39]. These patients mostly arrived for the first time in life threatening condition imposing a start of emergency dialysis without c-ART. These drugs are not directly available in the centre, but have to be order after the patient’s file has gone through a therapeutic comity. Also dialysis was initiated on a temporary catheter that was reported to increased morbidity and mortality of patients on RRT [40, 41]. Hospitalization rate in this study was similar in both groups. This is contrary to the reports of Fabian et al. where HIV infected patients had a higher rate of hospital admission mainly due to vascular access infection [18].
We acknowledge some limitations in this study such as the small sample size and the short length of follow up (one year) that could influence survival. Also viral load of HIV positive patients was not available, nor CD4 count during follow up. Those test were not done routinely by patients due to the high cost as payment is out of pocket. Therefore we could not determine whether the HIV infection was controlled or not. Despite these limitations, this first study could serve as a baseline for future studies on this group of patients.
Conclusion
We can conclude that in the c-ART area, survival of HIV-positive patients in Cameroon after one year on haemodialysis seems to be lower compared to their HIV-negative counterparts. This first result can serve as a basis for further studies with a large sample size and longer follow up period.
Notes
Author’s contribution
MPH, Study conception and design, writing of the manuscript; AEM, Data collection and critical revision of the manuscript; HF, Study design, supervision of data collection and critical revision of manuscript; HD, Data analysis and critical revision of manuscript; NE, Study design, acquisition and interpretation of data, critical revision of manuscript; GEA, Study conception and design, supervision of data collection and critical revision of manuscript. All authors gave their consent for publication. All authors read and approved the final manuscript.
Availability of data and materials
The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
Ethical approval was obtained from the Douala University Ethics Committee. Consent to participate was required and not applicable. We retrospectively used medical records.
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
References
- 1.GBD 2015 HIV Collaborators. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015. Lancet HIV 2016 Aug;3(8):e361–e387.Google Scholar
- 2.Go AS, Chertow GM, Fan D, McCulloch CE, Hsu C. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004 23;351(13):1296–1305.Google Scholar
- 3.Choi AI, Li Y, Deeks SG, Grunfeld C, Volberding PA, Shlipak MG. Association between kidney function and albuminuria with cardiovascular events in HIV-infected persons. Circulation. 2010;121(5):651–8.CrossRefPubMedPubMedCentralGoogle Scholar
- 4.Rosset S, Tzur S, Behar DM, Wasser WG, Skorecki K. The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus. Nat Rev Nephrol. 2011;7(6):313–26.CrossRefPubMedGoogle Scholar
- 5.Kopp JB, Smith MW, Nelson GW, Johnson RC, Freedman BI, Bowden DW, et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet. 2008;40(10):1175–84.CrossRefPubMedPubMedCentralGoogle Scholar
- 6.Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010;329(5993):841–5.CrossRefPubMedPubMedCentralGoogle Scholar
- 7.Fine DM, Wasser WG, Estrella MM, Atta MG, Kuperman M, Shemer R, et al. APOL1 risk variants predict histopathology and progression to ESRD in HIV-related kidney disease. J Am Soc Nephrol. 2012;23(2):343–50.CrossRefPubMedPubMedCentralGoogle Scholar
- 8.Lucas GM, Lau B, Atta MG, Fine DM, Keruly J, Moore RD. Chronic kidney disease incidence, and progression to end-stage renal disease, in HIV-infected individuals: a tale of two races. J Infect Dis. 2008;197(11):1548–57.CrossRefPubMedPubMedCentralGoogle Scholar
- 9.Ross MJ, Klotman PE, Winston JA. HIV-associated nephropathy: case study and review of the literature. AIDS Patient Care STDs. 2000;14(12):637–45.CrossRefPubMedGoogle Scholar
- 10.Ahuja TS, Grady J, Khan S. Changing trends in the survival of dialysis patients with human immunodeficiency virus in the United States. J Am Soc Nephrol. 2002;13(7):1889–93.CrossRefPubMedGoogle Scholar
- 11.Jotwani V, Li Y, Grunfeld C, Choi AI, Shlipak MG. Risk factors for ESRD in HIV-infected individuals: traditional and HIV-related factors. Am J Kidney Dis. 2012;59(5):628–35.CrossRefPubMedGoogle Scholar
- 12.Ortiz C, Meneses R, Jaffe D, Fernandez JA, Perez G, Bourgoignie JJ. Outcome of patients with human immunodeficiency virus on maintenance hemodialysis. Kidney Int. 1988;34(2):248–53.CrossRefPubMedGoogle Scholar
- 13.Feinfeld DA, Kaplan R, Dressler R, Lynn RI. Survival of human immunodeficiency virus-infected patients on maintenance dialysis. Clin Nephrol. 1989;32(5):221–4.PubMedGoogle Scholar
- 14.Kimmel PL, Umana WO, Simmens SJ, Watson J, Bosch JP. Continuous ambulatory peritoneal dialysis and survival of HIV infected patients with end-stage renal disease. Kidney Int. 1993;44(2):373–8.CrossRefPubMedGoogle Scholar
- 15.Rao TKS. Human immunodeficiency virus infection in end-stage renal disease patients. Semin Dial. 2003;16(3):233–44.CrossRefPubMedGoogle Scholar
- 16.Perinbasekar S, Brod-Miller C, Pal S, Mattana J. Predictors of survival in HIV-infected patients on hemodialysis. Am J Nephrol. 1996;16(4):280–6.CrossRefPubMedGoogle Scholar
- 17.Tourret J, Tostivint I, du Montcel ST, Bragg-Gresham J, Karie S, Vigneau C, et al. Outcome and prognosis factors in HIV-infected hemodialysis patients. Clin J Am Soc Nephrol. 2006;1(6):1241–7.CrossRefPubMedGoogle Scholar
- 18.Fabian J, Maher HA, Clark C, Naicker S, Becker P, Venter WDF. Morbidity and mortality of black HIV-positive patients with end-stage kidney disease receiving chronic haemodialysis in South Africa. S Afr Med J. 2015;105(2):110–4.CrossRefPubMedGoogle Scholar
- 19.Global report | UNAIDS [Internet]. [cited 2017 Sep 12]. Available from: http://www.unaids.org/en/resources/campaigns/globalreport2013/globalreport
- 20.Halle MP, Takongue C, Kengne AP, Kaze FF, Ngu KB. Epidemiological profile of patients with end stage renal disease in a referral hospital in Cameroon. BMC Nephrol. 2015 Dec;16(1):1471–2369.CrossRefGoogle Scholar
- 21.Halle MP, Luma H, Temfack E, Vanessa T, Kaze F, Ashuntantang G, et al. Prevalence of Hepatitis B surface antigen and anti-HIV antibodies among patients on maintenance haemodialysis in Douala, Cameroon. Health Sci Dis. 2013 Sep 1;14Google Scholar
- 22.Halle MP, Ashuntantang G, Kaze FF, Takongue C, Kengne A-P. Fatal outcomes among patients on maintenance haemodialysis in sub-Saharan Africa: a 10-year audit from the Douala general Hospital in Cameroon. BMC Nephrol. 2016;17(1):165.CrossRefPubMedPubMedCentralGoogle Scholar
- 23.Fouda H, Ashuntantang G, Kaze F, Halle M-P. Survival among chronic hemodialysed patient in Cameroon. Pan Afr Med J. 2017;26:97.CrossRefPubMedPubMedCentralGoogle Scholar
- 24.Osmond D. Epidemiology of HIV/AIDS in the United States [Internet]. [cited 2017 Nov 12]. Available from: http://hivinsite.ucsf.edu/InSite?page=kb-01-03
- 25.Fink S. Life and Death Choices as South Africans Ration Dialysis. [Internet]. ProPublica. 2010 [cited 2017 Sep 12]. Available from: https://www.propublica.org/article/dialysis-south-africa.
- 26.Moosa MR, Kidd M. The dangers of rationing dialysis treatment: the dilemma facing a developing country. Kidney Int. 2006;70(6):1107–14.CrossRefPubMedGoogle Scholar
- 27.Mbuagbaw J, Jingi AM, Noubiap JJN, Kaze AD, Nansseu JRN, Bigna JJR, et al. Patterns and trends in mortality among HIV-infected and HIV-uninfected patients in a major internal medicine unit in Yaoundé, Cameroon: a retrospective cohort study. JRSM Open. 2016;7(9):2054270416654859.Google Scholar
- 28.Mocroft A, Ledergerber B, Katlama C, Kirk O, Reiss P, d’Arminio Monforte A, et al. Decline in the AIDS and death rates in the EuroSIDA study: an observational study. Lancet. 2003;362(9377):22–9.CrossRefPubMedGoogle Scholar
- 29.Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators N Engl J Med. 1998;338(13):853–60.PubMedGoogle Scholar
- 30.Ahuja TS, Borucki M, Grady J. Highly active antiretroviral therapy improves survival of HIV-infected hemodialysis patients. Am J Kidney Dis. 2000 Sep;36(3):574–80.CrossRefPubMedGoogle Scholar
- 31.Rodriguez RA, Mendelson M, O’Hare AM, Hsu LC, Schoenfeld P. Determinants of survival among HIV-infected chronic dialysis patients. J Am Soc Nephrol. 2003;14(5):1307–13.CrossRefPubMedGoogle Scholar
- 32.Trullàs J-C, Barril G, Cofan F, Moreno A, Cases A, Fernandez-Lucas M, et al. Prevalence and clinical characteristics of HIV type 1-infected patients receiving Dialysis in Spain: results of a Spanish survey in 2006: GESIDA 48/05 study. AIDS Res Hum Retrovir. 2008;24(10):1229–35.CrossRefPubMedGoogle Scholar
- 33.Soleymanian T, Raman S, Shannaq FN, Richardson R, Jassal SV, Bargman J, et al. Survival and morbidity of HIV patients on hemodialysis and peritoneal dialysis: one center’s experience and review of the literature. Int Urol Nephrol. 2006;38(2):331–8.CrossRefPubMedGoogle Scholar
- 34.Zako F, Wambugu B, Radev M, Naicker S. Outcomes of chronic dialysis in HIV-infected patients. Presented at the ISN world congress of nephrology, Hong Kong, 31 May - 4 June 2013.Google Scholar
- 35.Saracho R, Martín EE, Comas JF, Arcos E, Mazuecos AB, Gentil MG, et al. Clinical evolution of chronic renal patients with HIV infection in replacement therapy. Nefrologia. 2015;35(5):457–64.CrossRefPubMedGoogle Scholar
- 36.Martínez E, Milinkovic A, Buira E, de Lazzari E, León A, Larrousse M, et al. Incidence and causes of death in HIV-infected persons receiving highly active antiretroviral therapy compared with estimates for the general population of similar age and from the same geographical area. HIV Med. 2007;8(4):251–8.CrossRefPubMedGoogle Scholar
- 37.Ifudu O, Mayers JD, Matthew JJ, Macey LJ, Brezsnyak W, Reydel C, et al. Uremia therapy in patients with end-stage renal disease and human immunodeficiency virus infection: has the outcome changed in the 1990s? Am J Kidney Dis. 1997;29(4):549–52.CrossRefPubMedGoogle Scholar
- 38.Schoenfeld P, Rodriguez R, Mendelson M. Patients with HIV infection and end-stage renal disease. Adv Ren Replace Ther. 1996;3(4, Part 2):287–92.CrossRefPubMedGoogle Scholar
- 39.Halle MPE, Kengne AP, Ashuntantang G. Referral of patients with kidney impairment for specialist care in a developing country of sub-Saharan Africa. Ren Fail. 2009;31(5):341–8.CrossRefPubMedGoogle Scholar
- 40.Levin A. Consequences of late referral on patient outcomes. Nephrol Dial Transplant. 2000;15(Suppl 3):8–13.CrossRefPubMedGoogle Scholar
- 41.Roubicek C, Brunet P, Huiart L, Thirion X, Leonetti F, Dussol B, et al. Timing of nephrology referral: influence on mortality and morbidity. Am J Kidney Dis. 2000;36(1):35–41.CrossRefPubMedGoogle Scholar
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