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Considerations in the Design and Analysis of Postoperative Dental Pain Studies

  • David A. Edelman
  • Leland D. Loose
Article

Abstract

The single-dose, postoperative dental pain impaction pain model initially was used for the evaluation of short-acting analgesics. In recent years, this model has been extended to the evaluation of long-acting analgesics and analgesics intended for the treatment of acute and/or chronic pain, and also has been modified to include a multiple-dose treatment period following the initial single-dose evaluation. These extensions have introduced potential biases and/or confounding factors that may complicate the interpretation of the study results. Some of the design and analysis issues related to these extensions are discussed, including the appropriate comparisons in single-dose studies, and the choice of dosing regimen and which subjects to include in the multiple-dose extension of single-dose studies.

Key Words

Dental pain model Analgesics Multiple dose 

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Copyright information

© Drug Information Association, Inc 2002

Authors and Affiliations

  • David A. Edelman
    • 1
  • Leland D. Loose
    • 2
  1. 1.Medical Research Consultants. Inc.San DiegoUSA
  2. 2.Pfizer Central ResearchPfizer, Inc.GrotonUSA

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