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Research on Chemical Intermediates

, Volume 26, Issue 3, pp 269–282 | Cite as

A study on the interactions between coenzyme Q 0 and superoxide anion. Could ubiquinones mimic superoxide dismutase (SOD)?

  • Rita Petrucci
  • Elisabetta Giorgini
  • Elisabetta Damiani
  • Patricia Carloni
  • Giancarlo Marrosu
  • Antonio Trazza
  • Gian Paolo Littarru
  • Lucedio Greci
Article

Abstract

An electrochemical study was carried out on 1,4-benzoquinone, duroquinone, coenzymes Q 0 and Q 10 in the absence and in the presence of molecular oxygen in aprotic (DMF) and protic (DMF/H2O 95:5 (v/v)) media. Water was added because the investigated reactions are deeply influenced by the presence of protons. Q 0 and Q 10 exhibited a similar electrochemical behaviour. Since Q 0 is more soluble in protic medium than the biologically more important analogue Q 10 , it was chosen as a model for a more detailed investigation. Voltammetric studies of Q 0 carried out in aprotic and protic media in the presence of oxygen showed that, besides simple O2 ·− dismutation, the Q 0 promoted dismutation of O2 ·− should also be considered. Spectroelectrochemical experiments with the same experimental conditions support the electrochemical results, showing that in the presence of superoxide and in aprotic medium semiquinone Q 0 ·− gives rise to a disproportionation equilibrium, while in the presence of water it tends to be reoxidized to the starting Q 0 by OOH·. EPR measurements are also in agreement with these results.

Keywords

Radical Anion Anodic Peak Ubiquinone Voltammetric Study Semiquinone Radical 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© VSP 2000

Authors and Affiliations

  • Rita Petrucci
    • 1
  • Elisabetta Giorgini
    • 2
  • Elisabetta Damiani
    • 2
  • Patricia Carloni
    • 2
  • Giancarlo Marrosu
    • 1
  • Antonio Trazza
    • 1
  • Gian Paolo Littarru
    • 3
  • Lucedio Greci
    • 2
  1. 1.Dipartimento di Ingegneria Chimica, dei Materiali, delle Materie Prime e MetallurgiaUniversità “La Sapienza”RomaItaly
  2. 2.Dipartimento di Scienze dei Materiali e della Terra, UniversitàAnconaItaly
  3. 3.Istituto di Biochimica, UniversitàAnconaItaly

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