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Extended Open image in new window -Regular Sequence for Automated Analysis of Microarray Images

  • Hee-Jeong JinEmail author
  • Bong-Kyung Chun
  • Hwan-Gue Cho
Open Access
Research Article
Part of the following topical collections:
  1. Advanced Signal Processing Techniques for Bioinformatics

Abstract

Microarray study enables us to obtain hundreds of thousands of expressions of genes or genotypes at once, and it is an indispensable technology for genome research. The first step is the analysis of scanned microarray images. This is the most important procedure for obtaining biologically reliable data. Currently most microarray image processing systems require burdensome manual block/spot indexing work. Since the amount of experimental data is increasing very quickly, automated microarray image analysis software becomes important. In this paper, we propose two automated methods for analyzing microarray images. First, we propose the extended Open image in new window -regular sequence to index blocks and spots, which enables a novel automatic gridding procedure. Second, we provide a methodology, hierarchical metagrid alignment, to allow reliable and efficient batch processing for a set of microarray images. Experimental results show that the proposed methods are more reliable and convenient than the commercial tools.

Keywords

Image Analysis Software Automate Analysis Batch Processing Microarray Study Gridding 

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Copyright information

© Hee-Jeong Jin et al. 2006

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors and Affiliations

  • Hee-Jeong Jin
    • 1
    • 2
    Email author
  • Bong-Kyung Chun
    • 1
    • 2
  • Hwan-Gue Cho
    • 1
    • 2
  1. 1.Department of Computer EngineeringPusan National UniversityKeumjeong-guKorea
  2. 2.Research Institute of Computer, Information, and CommunicationPusan National UniversityKeumjeong-guKorea

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