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Brain network dynamics characterization in epileptic seizures

Joint directed graph and pairwise synchronization measures

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  • Complex Networks
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Abstract

Here we propose and evaluate a new approach to analyse multichannel mesial temporal lobe epilepsy EEG data from eight patients through complex network and synchronization theories. The method employs a Granger causality test to infer the directed connectivity graphs and a wavelet transform based phase synchronization measure whose characteristics allow studying dynamical transitions during epileptic seizures. We present a new combined graph measure that quantifies the level of network hub formation, called network hub out-degree, which closely reflects the level of synchronization observed during the ictus.

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Authors and Affiliations

  1. Bioinformatics Interunits Graduate Program, University of São Paulo, São Paulo, Brazil

    A. C. Rodrigues

  2. Hospital Israelita Albert Einstein, São Paulo, Brazil

    B. S. Machado & E. Amaro Jr.

  3. Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil

    G. Florence

  4. Department of Neurosciences and Behavior, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil

    A. P. Hamad & A. C. Sakamoto

  5. Institute of Mathematic and Statistics, University of São Paulo, São Paulo, Brazil

    A. Fujita

  6. Department of Telecommunications and Control Engineering, Escola Politécnica, University of São Paulo, São Paulo, Brazil

    L. A. Baccalá

  7. Department of Radiology and Oncology, School of Medicine, University of São Paulo, São Paulo, Brazil

    A. C. Rodrigues, G. Florence, E. Amaro Jr. & K. Sameshima

Authors
  1. A. C. Rodrigues
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  2. B. S. Machado
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  3. G. Florence
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  4. A. P. Hamad
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  5. A. C. Sakamoto
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  6. A. Fujita
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  7. L. A. Baccalá
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  8. E. Amaro Jr.
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  9. K. Sameshima
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Correspondence to A. C. Rodrigues.

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Rodrigues, A.C., Machado, B.S., Florence, G. et al. Brain network dynamics characterization in epileptic seizures. Eur. Phys. J. Spec. Top. 223, 2933–2941 (2014). https://doi.org/10.1140/epjst/e2014-02306-8

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  • DOI: https://doi.org/10.1140/epjst/e2014-02306-8

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