The European Physical Journal Special Topics

, Volume 223, Issue 9, pp 1745–1754 | Cite as

DNA confinement drives uncoating of the HIV Virus

Regular Article
Part of the following topical collections:
  1. Soft Matter in Confinement: Systems from Biology to Physics

Abstract

The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model for the uncoating of the HIV virus where the capsid uncoating process is driven by the confinement force exerted on the capsid wall porduced to the double-stranded DNA generated by reverse transcriptase.

Keywords

European Physical Journal Special Topic Minor Radius Major Radius Thin Elastic Shell Mature Capsid 

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Copyright information

© EDP Sciences and Springer 2014

Authors and Affiliations

  1. 1.Department of Biochemistry, Molecular Biology and BiophysicsUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of Physics and Astronomy; Department of Chemistry and BiochemistryUniversity of CaliforniaLos AngelesUSA

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