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Modular approach for modeling cell motility

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Abstract

Modeling cell movement is a challenging task since the motility machinery is highly complex. Moreover, there is a rather broad diversity of different cell types. In order to obtain insights into generic features of the motility mechanisms of several distinct cell types, we propose a modular approach that starts with a minimal model, consisting of a phase field description of the moving cell boundary and a simplified internal dynamics. We discuss how this starting point can be extended to increase the level of detail, and how the internal dynamics “module” can be changed/adjusted to properly model various cell types. The former route allows studying specific processes involved in cell motility in the framework of a self-organized moving domain, and the latter might permit to put different cellular motility mechanisms into a unified framework.

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Authors and Affiliations

  1. Theoretische Physik I, Universität Bayreuth, 95440, Bayreuth, Germany

    F. Ziebert

  2. Materials Science Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL, 60439, USA

    I. S. Aranson

  3. Engineering Sciences and Applied Mathematics, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60202, USA

    I. S. Aranson

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  1. F. Ziebert
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  2. I. S. Aranson
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Correspondence to F. Ziebert.

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Ziebert, F., Aranson, I.S. Modular approach for modeling cell motility. Eur. Phys. J. Spec. Top. 223, 1265–1277 (2014). https://doi.org/10.1140/epjst/e2014-02190-2

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