The European Physical Journal Special Topics

, Volume 223, Issue 7, pp 1265–1277 | Cite as

Modular approach for modeling cell motility

Regular Article Papers
Part of the following topical collections:
  1. Discussion and Debate: Active Matter - How do Kinetic Theories Relate to Macroscopic Descriptions?

Abstract

Modeling cell movement is a challenging task since the motility machinery is highly complex. Moreover, there is a rather broad diversity of different cell types. In order to obtain insights into generic features of the motility mechanisms of several distinct cell types, we propose a modular approach that starts with a minimal model, consisting of a phase field description of the moving cell boundary and a simplified internal dynamics. We discuss how this starting point can be extended to increase the level of detail, and how the internal dynamics “module” can be changed/adjusted to properly model various cell types. The former route allows studying specific processes involved in cell motility in the framework of a self-organized moving domain, and the latter might permit to put different cellular motility mechanisms into a unified framework.

Keywords

European Physical Journal Special Topic Actin Polymerization Traction Force Adhesive Bond Internal Dynamic 

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Copyright information

© EDP Sciences and Springer 2014

Authors and Affiliations

  1. 1.Theoretische Physik IUniversität BayreuthBayreuthGermany
  2. 2.Materials Science DivisionArgonne National LaboratoryArgonneUSA
  3. 3.Engineering Sciences and Applied MathematicsNorthwestern UniversityEvanstonUSA

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