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The European Physical Journal E

, Volume 31, Issue 4, pp 419–428 | Cite as

Influence of cholesterol on the collective dynamics of the phospholipid acyl chains in model membranes

  • B. Brüning
  • M. C. Rheinstädter
  • A. Hiess
  • B. Weinhausen
  • T. Reusch
  • S. Aeffner
  • T. Salditt
Regular Article

Abstract

We have studied the packing and collective dynamics of the phospholipid acyl chains in a model membrane composed of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC) and cholesterol in varied phase state. After a structural characterization of this two-component model bilayer using X-ray reflectivity, we have carried out coherent inelastic neutron scattering to investigate the chain dynamics. Both DMPC/cholesterol membranes exhibited much sharper and more pronounced low-energy inelastic excitations than a pure DMPC membrane. In the high-energy regime above 10meV, the insertion of cholesterol into the membrane was found to shift the position of the inelastic excitation towards values otherwise found in the pure lipids gel phase. Thus, the dissipative collective short-range dynamics of the acyl chains is strongly influenced by the presence of cholesterol.

Keywords

Cholesterol Acyl Chain Inelastic Neutron Collective Dynamic Chain Dynamic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • B. Brüning
    • 1
    • 2
  • M. C. Rheinstädter
    • 3
  • A. Hiess
    • 1
  • B. Weinhausen
    • 2
  • T. Reusch
    • 2
  • S. Aeffner
    • 2
  • T. Salditt
    • 2
  1. 1.Institut Laue-LangevinGrenobleFrance
  2. 2.Institut für RöntgenphysikGöttingenGermany
  3. 3.Department of Physics and AstronomyMcMaster UniversityHamiltonCanada

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