The European Physical Journal E

, Volume 19, Issue 3, pp 367–369 | Cite as

The view from the biochemist

Comment on “Chromatin code, local non-equilibrium dynamics, and the emergence of transcription regulatory programs” by Arndt Benecke
Focus Point


The review by Arndt Benecke focuses on chromatin, a major hallmark of eukaryotic life. The dynamic of chromatin and its underlying mechanisms are discussed. In addition, theoretical properties of chromatin associated with transcriptional regulation are presented. In the present brief comment on the review by Arndt Benecke, we wish to provide additional information regarding chromatin structure and in particular on the so-called “histone code hypothesis”. We will discuss about the emerging idea that chromatin structure is much more complex than previously thought. The possibility that chromatin modifications may play important roles in biology beside transcriptional regulation will also be put forward.


87.15.Aa Theory and modeling; computer simulation 87.16.-b Subcellular structure and processes 87.16.Sr Chromosomes, histones 


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  1. 1.
    T. Jenuwein, C.D. Allis, Science 293, 1074 (2001).CrossRefGoogle Scholar
  2. 2.
    R. Margueron, P. Trojer, D. Reinberg, Curr. Opin. Genet. Dev. 15, 163 (2005).CrossRefGoogle Scholar
  3. 3.
    J. Nakayama, J.C. Rice, B.D. Strahl, C.D. Allis, S.I. Grewal, Science 292, 110 (2001).CrossRefADSGoogle Scholar
  4. 4.
    P. Cheung, K.G. Tanner, W.L. Cheung, P. Sassone-Corsi, J.M. Denu, C.D. Allis, Mol. Cell 5, 905 (2000).CrossRefGoogle Scholar
  5. 5.
    W.S. Lo, R.C. Trievel, J.R. Rojas, L. Duggan, J.Y. Hsu, C.D. Allis, R. Marmorstein, S.L. Berger, Mol. Cell 5, 917 (2000).CrossRefGoogle Scholar
  6. 6.
    S. Rea, F. Eisenhaber, D. O'Carroll, B.D. Strahl, Z.W. Sun, M. Schmid, S. Opravil, K. Mechtler, C.P. Ponting, C.D. Allis, T. Jenuwein, Nature 406, 593 (2000). CrossRefADSGoogle Scholar
  7. 7.
    S.L. Schreiber, B.E. Bernstein, Cell 111, 771 (2002).CrossRefGoogle Scholar
  8. 8.
    S.K. Kurdistani, M. Grunstein, Nat. Rev. Mol. Cell. Biol. 4, 276 (2003).CrossRefGoogle Scholar
  9. 9.
    T. Kouzarides, Curr. Opin. Genet. Dev. 9, 40 (1999).CrossRefGoogle Scholar
  10. 10.
    X.J. Yang, E. Seto, Curr. Opin. Genet. Dev. 13, 143 (2003).CrossRefMATHGoogle Scholar
  11. 11.
    P. Sassone-Corsi, C.A. Mizzen, P. Cheung, C. Crosio, L. Monaco, S. Jacquot, A. Hanauer, C.D. Allis, Science 285, 886 (1999).CrossRefGoogle Scholar
  12. 12.
    S. Thomson, A.L. Clayton, C.A. Hazzalin, S. Rose, M.J. Barratt, L.C. Mahadevan, EMBO J. 18, 4779 (1999).CrossRefGoogle Scholar
  13. 13.
    H. Santos-Rosa, R. Schneider, A.J. Bannister, J. Sherriff, B.E. Bernstein, N.C. Emre, S.L. Schreiber, J. Mellor, T. Kouzarides, Nature 419, 407 (2002).CrossRefADSGoogle Scholar
  14. 14.
    A.J. Bannister, T. Kouzarides, Nature 436, 1103 (2005).CrossRefADSGoogle Scholar
  15. 15.
    H. van Attikum, S.M. Gasser, Nat. Rev. Mol. Cell. Biol. 6, 757 (2005).CrossRefGoogle Scholar
  16. 16.
    Y. Huyen, O. Zgheib, R.A. Ditullio jr., V.G. Gorgoulis, P. Zacharatos, T.J. Petty, E.A. Sheston, H.S. Mellert, E.S. Stavridi, T.D. Halazonetis, Nature 432, 406 (2004).CrossRefADSGoogle Scholar
  17. 17.
    S.L. Sanders, M. Portoso, J. Mata, J. Bahler, R.C. Allshire, T. Kouzarides, Cell 119, 603 (2004).CrossRefGoogle Scholar

Copyright information

© EDP Sciences, Società Italiana di Fisica and Springer-Verlag 2006

Authors and Affiliations

  1. 1.Faculty of Medicine, Laboratory of Molecular VirologyFree University of BrusselsBrusselsBelgium

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