The European Physical Journal E

, Volume 7, Issue 4, pp 393–396 | Cite as

Solute effects on the helix-coil transition

  • O. Farago
  • P. Pincus
Article

Abstract:

We discuss the effects of the solvent composition on the helix-coil transition of a polypeptide chain. We use a simple model to demonstrate that improving the hydrogen-bonding ability of the solvent can make the transition less cooperative, without affecting the transition temperature. This effect is very different from other solvent effects which primarily influence the melting transition rather than the cooperativity.

PACS. 87.15.-v Biomolecules: structure and physical properties – 05.70.Fh Phase transitions: general studies – 61.41.+e Polymers, elastomers, and plastics 

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Copyright information

© EDP Sciences, Springer-Verlag, Società Italiana di Fisica 2002

Authors and Affiliations

  • O. Farago
    • 1
  • P. Pincus
    • 1
  1. 1.Materials Research Laboratory, University of CaliforniaSanta BarbaraUSA

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