In the topcolor-assisted technicolor (TC2) model, the typical physical particles, top-pions and top-Higgs, are predicted and the existence of these particles could be regarded as robust evidence for the model. These particles are accessible at the Tevatron and LHC, and furthermore the flavor-changing (FC) feature of the TC2 model may provide us with a unique opportunity to probe them. In this paper, we study some interesting FC production processes of top-pions and top-Higgs particles at the Tevatron and LHC, i.e., cΠt- and cΠt0(ht0) productions. We find that the light charged top-pions are not favorable by the Tevatron experiments, and the Tevatron has little capability to probe the neutral top-pion and top-Higgs particles via these FC production processes. At LHC, however, the cross section can reach the level of 10–100 pb for cΠt- production and 10–100 fb for cΠt0(ht0) production. So one can expect that enough signals could be produced at the LHC experiments. Furthermore, the SM backgrounds should be clean due to the FC feature of the processes, and the FC decay modes Πt-→bc̄, Πt0(ht0)→tc̄ can provide us with the signal typical for the detection of the top-pions and top-Higgs particles. Therefore, one may have hope to find the signal of top-pions and top-Higgs particles with the running of LHC via these FC processes.