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Alzheimer’s disease markers from structural MRI and FDG-PET brain images

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Abstract

Despite the widespread use of neuroimaging tools (morphological and functional) in the routine diagnostic of cerebral diseases, the information available by the end user -the clinician- remains largely limited to qualitative visual analysis. This restriction greatly reduces the diagnostic impact of neuroimaging in routine clinical practice and increases the risk of misdiagnosis. In this context, researches are focussing on the development of sophisticated automatic analyses able to extract clinically relevant information from the captured data. The identification of biological markers at early stages of Alzheimer’s disease (AD) contributes to diagnostic accuracy and adds prognostic value. However, in spite of recent developments, results of structural and functional imaging studies on predicting conversion to AD are not uniform. We provide here an overview of analysis methods and approaches, discussing their contribution to clinical assessment.

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References

  1. J.L. Cummings, R. Doody, C. Clark, Neurology 69, 1622 (2007)

    Google Scholar 

  2. B. Dubois, H.H. Feldman, C. Jacova, S.T. DeKosky, P. Barberger-Gateau, J. Cummings, A. Delacourte, D. Galasko, S. Gauthier, G. Jicha, Lancet Neurology 6, 734 (2007)

    Google Scholar 

  3. B. Dubois, H.H. Feldman, C. Jacova, J.L. Cummings, S.T. DeKosky, P. Barberger-Gateau, A. Delacourte, G. Frisoni, N.C. Fox, D. Galasko, Lancet Neurology 9, 1118 (2010)

    Google Scholar 

  4. R.A. Sperling, P.S. Aisen, L.A. Beckett, D.A. Bennett, S. Craft, A.M. Fagan, T. Iwatsubo, C.R. Jack, J. Kaye, T.J. Montine, D.C. Park, E.M. Reiman, C.C. Rowe, E. Siemers, Y. Stern, K. Yaffe, M.C. Carrillo, B. Thies, M. Morrison-Bogorad, M.V. Wagster, C.H. Phelps, Alzheimer Dement. J. 7, 280 (2011)

    Google Scholar 

  5. R.C. Petersen, R. Doody, A. Kurz, R.C. Mohs, J.C. Morris, P.V. Rabins, K. Ritchie, M. Rossor, L. Thal, B. Winblad, Arch. Neurol. 58, 1985 (2001)

    Google Scholar 

  6. O.V. Forlenza, E. Chiu, Curr. Opin. Psychiatry 21, 529 (2008)

    Google Scholar 

  7. A. Busse, A. Hensel, U. Gühne, M.C. Angermeyer, S.G. Riedel-Heller, Neurology 67, 2176 (2006)

    Google Scholar 

  8. S.T. Farias, D. Mungas, B.R. Reed, D. Harvey, C. DeCarli, Arch. Neurol. 66, 1151 (2009)

    Google Scholar 

  9. B.S.O. Diniz, J.A.P. Júnior, O.V. Forlenza, World J. Biol. Psychiatry 9, 172 (2008)

    Google Scholar 

  10. M.L. Ries, C.M. Carlsson, H.A. Rowley, M.A. Sager, C.E. Gleason, S. Asthana, S.C. Johnson, J. Am. Geriatr. Soc. 56, 920 (2008)

    Google Scholar 

  11. W. Jagust, B. Reed, D. Mungas, W. Ellis, C. Decarli, Neurology 69, 871 (2007)

    Google Scholar 

  12. L.K. Ferreira, B.S. Diniz, O.V. Forlenza, G.F. Busatto, M.V. Zanetti, Neurobiol. Aging 32, 1733 (2011)

    Google Scholar 

  13. J. Hardy, D.J. Selkoe, Science 297, 353 (2002)

    ADS  Google Scholar 

  14. G.H. Malthankar-Phatak, Y.-G. Lin, N. Giovannone, R. Siman, Aging Disease 3, 141 (2012)

    Google Scholar 

  15. C.R. Jack, D.S. Knopman, W.J. Jagust, L.M. Shaw, P.S. Aisen, M.W. Weiner, R.C. Petersen, J.Q. Trojanowski, Lancet Neurology 9, 119 (2010)

    Google Scholar 

  16. G.F. Busatto, B.S. Diniz, M.V. Zanetti, Expert Rev. Neurotherapeutics 8, 1691 (2008)

    Google Scholar 

  17. C. Testa, M.P. Laakso, F. Sabattoli, R. Rossi, A. Beltramello, H. Soininen, G.B. Frisoni, J. Magn. Reson. Imaging 19, 274 (2004)

    Google Scholar 

  18. M. Boccardi, R. Ganzola, M. Bocchetta, M. Pievani, A. Redolfi, G. Bartzokis, R. Camicioli, J.G. Csernansky, M.J. de Leon, L. DeToledo-Morrell, R.J. Killiany, S. Lehéricy, J. Pantel, J.C. Pruessner, H. Soininen, C. Watson, S. Duchesne, C.R. Jack, G.B. Frisoni, J. Alzheimer Disease 26, Suppl. 3, 61 (2011)

    Google Scholar 

  19. M.F. Folstein, S.E. Folstein, P.R. McHugh, J. Psychiatr. Res. 12, 189 (1975)

    Google Scholar 

  20. J.C. Morris, Neurology 43, 2412 (1993)

    Google Scholar 

  21. B. Reisberg, S.H. Ferris, M.J. de Leon, T. Crook, Am. J. Psychiatry 139, 1136 (1982)

    Google Scholar 

  22. J.Y. Choe, J.C. Youn, J.H. Park, I.S. Park, J.W. Jeong, W.H. Lee, S.B. Lee, Y.S. Park, J.H. Jhoo, D.Y. Lee, K.W. Kim, Dementia Geriatr. Cogn. Disord. 25, 321 (2008)

    Google Scholar 

  23. G.B. Frisoni, N.C. Fox, C.R. Jack, P. Scheltens, P.M. Thompson, Nature Rev. Neurol. 6, 67 (2010)

    Google Scholar 

  24. O.V. Forlenza, B.S. Diniz, W.F. Gattaz, BMC Medicine 8, 89 (2010)

    Google Scholar 

  25. P. Scheltens, D. Leys, F. Barkhof, D. Huglo, H.C. Weinstein, P. Vermersch, M. Kuiper, M. Steinling, E.C. Wolters, J. Valk, J. Neurol. Neurosurg. Psychiatry 55, 967 (1992)

    Google Scholar 

  26. G. Chetelat, J.-C. Baron, NeuroImage 18, 525 (2003)

    Google Scholar 

  27. C.J. Galton, B. Gomez-Anson, N. Antoun, P. Scheltens, K. Patterson, M. Graves, B.J. Sahakian, J.R. Hodges, J. Neurol. Neurosurg. Psychiatry 70, 165 (2001)

    Google Scholar 

  28. C.R. Jack, M.A. Bernstein, N.C. Fox, P. Thompson, G. Alexander, D. Harvey, B. Borowski, P.J. Britson, J.L. Whitwell, C. Ward, A.M. Dale, J.P. Felmlee, J.L. Gunter, D.L.G. Hill, R. Killiany, N. Schuff, S. Fox-Bosetti, C. Lin, C. Studholme, C.S. DeCarli, G. Krueger, H.A. Ward, G.J. Metzger, K.T. Scott, R. Mallozzi, D. Blezek, J. Levy, J.P. Debbins, A.S. Fleisher, M. Albert, R. Green, G. Bartzokis, G. Glover, J. Mugler, M.W. Weiner, J. Magn. Res. Imaging 27, 685 (2008)

    Google Scholar 

  29. J.V. Hajnal, A. Oatridge, A.H. Herlihy, G.M. Bydder, Am. J. Neuroradiol. 22, 317 (2001)

    Google Scholar 

  30. J. Jovicich, S. Czanner, D. Greve, E. Haley, A. van der Kouwe, R. Gollub, D. Kennedy, F. Schmitt, G. Brown, J. Macfall, B. Fischl, A. Dale, NeuroImage 30, 436 (2006)

    Google Scholar 

  31. P.A. Narayana, W.W. Brey, M.V. Kulkarni, C.L. Sievenpiper, Magn. Res. Imaging 6, 271 (1988)

    Google Scholar 

  32. J. Ashburner, NeuroImage 38, 95 (2007)

    Google Scholar 

  33. S. Klöppel, C.M. Stonnington, C. Chu, B. Draganski, R.I. Scahill, J.D. Rohrer, N.C. Fox, C.R. Jack, J. Ashburner, R.S.J. Frackowiak, Brain 131, 681 (2008)

    Google Scholar 

  34. P. Vemuri, J.L. Gunter, M.L. Senjem, J.L. Whitwell, K. Kantarci, D.S. Knopman, B.F. Boeve, R.C. Petersen, C.R. Jack, NeuroImage 39, 1186 (2008)

    Google Scholar 

  35. Z. Lao, NeuroImage 21, 46 (2004)

    Google Scholar 

  36. B. Magnin, L. Mesrob, S. Kinkingnéhun, M. Pélégrini-Issac, O. Colliot, M. Sarazin, B. Dubois, S. Lehéricy, H. Benali, Neuroradiology 51, 73 (2009)

    Google Scholar 

  37. R.A. Heckemann, S. Keihaninejad, P. Aljabar, K.R. Gray, C. Nielsen, D. Rueckert, J.V. Hajnal, A. Hammers, NeuroImage 56, 2024 (2011)

    Google Scholar 

  38. Y. Fan, N. Batmanghelich, C.M. Clark, C. Davatzikos, NeuroImage 39, 1731 (2008)

    Google Scholar 

  39. Y. Fan, S.M. Resnick, X. Wu, C. Davatzikos, NeuroImage 41, 277 (2008)

    Google Scholar 

  40. A. Chincarini, P. Bosco, P. Calvini, G. Gemme, M. Esposito, C. Olivieri, L. Rei, S. Squarcia, G. Rodriguez, R. Bellotti, P. Cerello, I. De Mitri, A. Retico, F. Nobili, NeuroImage 58, 469 (2011)

    Google Scholar 

  41. P.M. Thompson, K.M. Hayashi, G.I. De Zubicaray, A.L. Janke, S.E. Rose, J. Semple, M.S. Hong, D.H. Herman, D. Gravano, D.M. Doddrell, A.W. Toga, NeuroImage 22, 1754 (2004)

    Google Scholar 

  42. P.M. Thompson, K.M. Hayashi, G. De Zubicaray, A.L. Janke, S.E. Rose, J. Semple, D. Herman, M.S. Hong, S.S. Dittmer, D.M. Doddrell, A.W. Toga, J. Neurosci. 23, 994 (2003)

    Google Scholar 

  43. J.P. Lerch, J. Pruessner, A.P. Zijdenbos, D.L. Collins, S.J. Teipel, H. Hampel, A.C. Evans, Neurobiol. Aging 29, 23 (2008)

    Google Scholar 

  44. A. Bakkour, J.C. Morris, B.C. Dickerson, Neurology 72, 1048 (2009)

    Google Scholar 

  45. B.C. Dickerson, A. Bakkour, D.H. Salat, E. Feczko, J. Pacheco, D.N. Greve, F. Grodstein, C.I. Wright, D. Blacker, H.D. Rosas, R.A. Sperling, A. Atri, J.H. Growdon, B.T. Hyman, J.C. Morris, B. Fischl, R.L. Buckner, Cerebral cortex 19, 497 (2009)

    Google Scholar 

  46. B.C. Dickerson, E. Feczko, J.C. Augustinack, J. Pacheco, J.C. Morris, B. Fischl, R.L. Buckner, Neurobiol. Aging 30, 432 (2009)

    Google Scholar 

  47. M. Chupin, E. Gérardin, R. Cuingnet, C. Boutet, L. Lemieux, S. Lehéricy, H. Benali, L. Garnero, O. Colliot, Hippocampus 19, 579 (2009)

    Google Scholar 

  48. M. Chupin, A.R. Mukuna-Bantumbakulu, D. Hasboun, E. Bardinet, S. Baillet, S. Kinkingnéhun, L. Lemieux, B. Dubois, L. Garnero, NeuroImage 34, 996 (2007)

    Google Scholar 

  49. M.J. de Leon, J. Golomb, A.E. George, A. Convit, C.Y. Tarshish, T. McRae, S. De Santi, G. Smith, S.H. Ferris, M. Noz, Am. J. Neuroradiol. 14, 897 (1993)

    Google Scholar 

  50. C.R. Jack, R.C. Petersen, Y.C. Xu, P.C. O'Brien, G.E. Smith, R.J. Ivnik, B.F. Boeve, S.C. Waring, E.G. Tangalos, E. Kokmen, Neurology 52, 1397 (1999)

    Google Scholar 

  51. R. Duara, D.A. Loewenstein, E. Potter, J. Appel, M.T. Greig, R. Urs, Q. Shen, A. Raj, B. Small, W. Barker, E. Schofield, Y. Wu, H. Potter, Neurology 71, 1986 (2008)

    Google Scholar 

  52. J. Barnes, R.G. Boyes, E.B. Lewis, J.M. Schott, C. Frost, R.I. Scahill, N.C. Fox, Neurobiol. Aging 28, 1657 (2007)

    Google Scholar 

  53. G.B. Frisoni, M.P. Laakso, A. Beltramello, C. Geroldi, A. Bianchetti, H. Soininen, M. Trabucchi, Neurology 52, 91 (1999)

    Google Scholar 

  54. V.N. Vapnik, The nature of statistical learning theory (1995)

  55. J. Shawe-Taylor, N. Cristianini, Kernel Methods for Pattern Analysis (Cambridge University Press, 2004)

  56. B. Schölkopf, A.J. Smola, Learning with Kernels: Support Vector Machines, Regularization, Optimization, and Beyond (MIT Press, 2002)

  57. L. Breiman, Random Forests, Vol. 45 (Springer, Netherlands, 2001)

  58. J.A. Hanley, B.J. McNeil, Radiology 143, 29 (1982)

    Google Scholar 

  59. X. Hua, S. Lee, I. Yanovsky, A.D. Leow, Y.-Y. Chou, A.J. Ho, B. Gutman, A.W. Toga, C.R. Jack, M.A. Bernstein, E.M. Reiman, D.J. Harvey, J. Kornak, N. Schuff, G.E. Alexander, M.W. Weiner, P.M. Thompson, NeuroImage 48, 668 (2009)

    Google Scholar 

  60. C.R. McDonald, L.K. McEvoy, L. Gharapetian, C. Fennema-Notestine, D.J. Hagler, D. Holland, A. Koyama, J.B. Brewer, A.M. Dale, Neurology 73, 457 (2009)

    Google Scholar 

  61. E. Gerardin, G. Chételat, M. Chupin, R. Cuingnet, B. Desgranges, H.-S. Kim, M. Niethammer, B. Dubois, S. Lehéricy, L. Garnero, F. Eustache, O. Colliot, NeuroImage 47, 1476 (2009)

    Google Scholar 

  62. Y. Fan, D. Shen, R.C. Gur, R.E. Gur, C. Davatzikos, IEEE Trans. Med. Imaging 26, 93 (2007)

    Google Scholar 

  63. R.S. Desikan, H.J. Cabral, C.P. Hess, W.P. Dillon, C.M. Glastonbury, M.W. Weiner, N.J. Schmansky, D.N. Greve, D.H. Salat, R.L. Buckner, B. Fischl, Brain 132, 2048 (2009)

    Google Scholar 

  64. R. Cuingnet, E. Gérardin, J. Tessieras, G. Auzias, S. Lehéricy, M.-O. Habert, M. Chupin, H. Benali, O. Colliot, NeuroImage 56, 766 (2010)

    Google Scholar 

  65. W. Lehnert, M.-C. Gregoire, A. Reilhac, S.R. Meikle, NeuroImage 60, 2144 (2012)

    Google Scholar 

  66. H. Wang, B. Fei, Med. Phys. 39, 179 (2012)

    ADS  Google Scholar 

  67. P.J. Magistretti, Brain Res. 886, 108 (2000)

    Google Scholar 

  68. L. Sokoloff, J. Neurochem. 29, 13 (1977)

    Google Scholar 

  69. A.B. Rocher, F. Chapon, X. Blaizot, J.-C. Baron, C. Chavoix, NeuroImage 20, 1894 (2003)

    Google Scholar 

  70. M.J. de Leon, A. Convit, O.T. Wolf, C.Y. Tarshish, S. DeSanti, H. Rusinek, W. Tsui, E. Kandil, A.J. Scherer, A. Roche, A. Imossi, E. Thorn, M. Bobinski, C. Caraos, P. Lesbre, D. Schlyer, J. Poirier, B. Reisberg, J. Fowler, Proc. Natl. Acad. Sci. U.S.A. 98, 10966 (2001)

    ADS  Google Scholar 

  71. L. Mosconi, D. Perani, S. Sorbi, K. Herholz, B. Nacmias, V. Holthoff, E. Salmon, J.-C. Baron, M.T.R. De Cristofaro, A. Padovani, B. Borroni, M. Franceschi, L. Bracco, A. Pupi, Neurology 63, 2332 (2004)

    Google Scholar 

  72. N. Scarmeas, C.G. Habeck, E. Zarahn, K.E. Anderson, A. Park, J. Hilton, G.H. Pelton, M.H. Tabert, L.S. Honig, J.R. Moeller, D.P. Devanand, Y. Stern, NeuroImage 23, 35 (2004)

    Google Scholar 

  73. A. Drzezga, T. Grimmer, M. Riemenschneider, N. Lautenschlager, H. Siebner, P. Alexopoulus, S. Minoshima, M. Schwaiger, A. Kurz, J. Nucl. Med. 46, 1625 (2005)

    Google Scholar 

  74. A. Drzezga, N. Lautenschlager, H. Siebner, M. Riemenschneider, F. Willoch, S. Minoshima, M. Schwaiger, A. Kurz, Eur. J. Nucl. Med. Mol. Imaging 30, 1104 (2003)

    Google Scholar 

  75. P.J. Nestor, T.D. Fryer, P. Smielewski, J.R. Hodges, Ann. Neurol. 54, 343 (2003)

    Google Scholar 

  76. S. Morbelli, A. Piccardo, G. Villavecchia, B. Dessi, A. Brugnolo, A. Piccini, A. Caroli, G. Frisoni, G. Rodriguez, F. Nobili, Eur. J. Nucl. Med. Mol. Imaging 37, 36 (2010)

    Google Scholar 

  77. A. Caroli, C. Testa, C. Geroldi, F. Nobili, L.R. Barnden, U.P. Guerra, M. Bonetti, G.B. Frisoni, J. Neurol. 254, 1698 (2007)

    Google Scholar 

  78. B.P. Rogers, V.L. Morgan, A.T. Newton, J.C. Gore, Magn. Res. Imaging 25, 1347 (2007)

    Google Scholar 

  79. A. Hafkemeijer, J. van der Grond, S.A.R.B. Rombouts, Biochim. Biophys. Acta 1822, 431 (2012)

    Google Scholar 

  80. F. Nobili, D. Salmaso, S. Morbelli, N. Girtler, A. Piccardo, A. Brugnolo, B. Dessi, S.A. Larsson, G. Rodriguez, M. Pagani, Eur. J. Nucl. Med. Mol. Imaging 35, 2191 (2008)

    Google Scholar 

  81. D.S. Lee, H. Kang, H. Kim, H. Park, J.S. Oh, J.S. Lee, M.C. Lee, Eur. J. Nucl. Med. Mol. Imaging 35, 1681 (2008)

    Google Scholar 

  82. R.L. Van Heertum, R.S. Tikofsky, Semin. Nucl. Med. 33, 77 (2003)

    Google Scholar 

  83. J.M. Hoffman, K.A. Welsh-Bohmer, M. Hanson, B. Crain, C. Hulette, N. Earl, R.E. Coleman, J. Nucl. Med. 41, 1920 (2000)

    Google Scholar 

  84. S. Morbelli, A. Drzezga, R. Perneczky, G.B. Frisoni, A. Caroli, B.N.M. van Berckel, R. Ossenkoppele, E. Guedj, M. Didic, A. Brugnolo, G. Sambuceti, M. Pagani, E. Salmon, F. Nobili, Neurobiol. Aging 33, 2533 (2012)

    Google Scholar 

  85. E. Moser, F. Stahlberg, M.E. Ladd, S. Trattnig, 7-T MR-from research to clinical applications? in NMR in biomedicine (2011)

  86. S.G. Mueller, N. Schuff, K. Yaffe, C. Madison, B. Miller, M.W. Weiner, Hum. Brain Mapp. 31, 1339 (2010)

    Google Scholar 

  87. G.B. Frisoni, R. Ganzola, E. Canu, U. Rüb, F.B. Pizzini, F. Alessandrini, G. Zoccatelli, A. Beltramello, C. Caltagirone, P.M. Thompson, Brain 131, 3266 (2008)

    Google Scholar 

  88. Z.-H. Cho, J.-Y. Han, S.-I. Hwang, D.-S. Kim, K.-N. Kim, N.-B. Kim, S.J. Kim, J.-G. Chi, C.-W. Park, Y.-B. Kim, NeuroImage 49, 2134 (2010)

    Google Scholar 

  89. B.J. Jellison, A.S. Field, J. Medow, M. Lazar, M.S. Salamat, A.L. Alexander, Am. J. Neuroradiol. 25, 356 (2004)

    Google Scholar 

  90. K.M. Hasan, I.S. Walimuni, H. Abid, K.R. Hahn, Comput. Biol. Med. 41, 1062 (2011)

    Google Scholar 

  91. D.K. Jones, Cortex 44, 936 (2008)

    Google Scholar 

  92. C.E. Sexton, C.E. Mackay, J.A. Lonie, M.E. Bastin, E. Terrière, R.E. O'Carroll, K.P. Ebmeier, Psychiatr. Res. 184, 57 (2010)

    Google Scholar 

  93. M. Ewers, G.B. Frisoni, S.J. Teipel, L.T. Grinberg, E. Amaro, H. Heinsen, P.M. Thompson, H. Hampel, Prog. Neurobiol. 95, 535 (2011)

    Google Scholar 

  94. B. Bosch, E.M. Arenaza-Urquijo, L. Rami, R. Sala-Llonch, C. Junqué, C. Solé-Padullés, C. Peña-Gómez, N. Bargalló, J.L. Molinuevo, D. Bartrés-Faz, Neurobiol. Aging 33, 61 (2012)

    Google Scholar 

  95. F. Palesi, P. Vitali, P. Chiarati, G. Castellazzi, E. Caverzasi, A. Pichiecchio, E. Colli-Tibaldi, F. D'Amore, I. D'Errico, E. Sinforiani, S. Bastianello, Neurol. Res. Int. 2012, 517876 (2012)

    Google Scholar 

  96. K. Yamada, Proc. Natl. Acad. Sci. U.S.A. 106, E14 (2009) 106

    ADS  Google Scholar 

  97. H. Quigley, S.J. Colloby, J.T. O'Brien, Int. J. Geriatr. Psychiatr. 26, 991 (2011)

    Google Scholar 

  98. M.J. Pontecorvo, M.A. Mintun, Alzheimer Res. Ther. 3, 11 (2011)

    Google Scholar 

  99. G.D. Rabinovici, W.J. Jagust, Behav. Neurol. 21, 117 (2009)

    Google Scholar 

  100. H.J. Aizenstein, R.D. Nebes, J.A. Saxton, J.C. Price, C.A. Mathis, N.D. Tsopelas, S.K. Ziolko, J.A. James, B.E. Snitz, P.R. Houck, W. Bi, A.D. Cohen, B.J. Lopresti, S.T. DeKosky, E.M. Halligan, W.E. Klunk, Arch. Neurol. 65, 1509 (2008)

    Google Scholar 

  101. C. Holmes, D. Boche, D. Wilkinson, G. Yadegarfar, V. Hopkins, A. Bayer, R.W. Jones, R. Bullock, S. Love, J.W. Neal, E. Zotova, J.A.R. Nicoll, Lancet 372, 216 (2008)

    Google Scholar 

  102. D. Zhang, D. Shen, PloS One 7, e33182 (2012)

    MathSciNet  ADS  Google Scholar 

  103. L.K. McEvoy, D. Holland, D.J. Hagler, C. Fennema-Notestine, J.B. Brewer, A.M. Dale, Radiology 259, 834 (2011)

    Google Scholar 

  104. M.L. Ries, C.M. Carlsson, H.A. Rowley, M.A. Sager, C.E. Gleason, S. Asthana, S.C. Johnson, J. Am. Geriatr. Soc. 56, 920 (2008)

    Google Scholar 

  105. R. Ossenkoppele, N. Tolboom, J.C. Foster-Dingley, S.F. Adriaanse, R. Boellaard, M. Yaqub, A.D. Windhorst, F. Barkhof, A.A. Lammertsma, P. Scheltens, W.M. van der Flier, B.N.M. van Berckel, Eur. J. Nucl. Med. Mol. Imaging 39, 990 (2012)

    Google Scholar 

  106. S. Förster, T. Grimmer, I. Miederer, G. Henriksen, B.H. Yousefi, P. Graner, H.-J. Wester, H. Förstl, A. Kurz, B.C. Dickerson, P. Bartenstein, A. Drzezga, Biol. Psychiatry 71, 792 (2012)

    Google Scholar 

  107. M. Ewers, R.A. Sperling, W.E. Klunk, M.W. Weiner, H. Hampel, Trends Neurosci. 34, 430 (2011)

    Google Scholar 

  108. C.R. Jack, V.J. Lowe, M.L. Senjem, S.D. Weigand, B.J. Kemp, M.M. Shiung, D.S. Knopman, B.F. Boeve, W.E. Klunk, C.A. Mathis, R.C. Petersen, Brain 131, 665 (2008)

    Google Scholar 

  109. K.B. Walhovd, A.M. Fjell, A.M. Dale, L.K. McEvoy, J. Brewer, D.S. Karow, D.P. Salmon, C. Fennema-Notestine, Neurobiol. Aging 31, 1107 (2010)

    Google Scholar 

  110. K.B. Walhovd, A.M. Fjell, J. Brewer, L.K. McEvoy, C. Fennema-Notestine, D.J. Hagler, R.G. Jennings, D. Karow, A.M. Dale, Am. J. Neuroradiol. 31, 347 (2010)

    Google Scholar 

  111. E. Westman, J.-S. Muehlboeck, A. Simmons, NeuroImage 62, 229 (2012)

    Google Scholar 

  112. L.-H. Guo, P. Alexopoulos, T. Eisele, S. Wagenpfeil, A. Kurz, R. Perneczky, Eur. Arch. Psychiatr. Clin. Neurosci. (2012) available at http://dx.doi.org/10.1007/s00406-012-0349-0

  113. B.T. Hyman, C.H. Phelps, T.G. Beach, E.H. Bigio, N.J. Cairns, M.C. Carrillo, D.W. Dickson, C. Duyckaerts, M.P. Frosch, E. Masliah, S.S. Mirra, P.T. Nelson, J.A. Schneider, D.R. Thal, B. Thies, J.Q. Trojanowski, H.V. Vinters, T.J. Montine, Alzheimer Dementia 8, 1 (2012)

    Google Scholar 

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Authors and Affiliations

  1. INFN, Sezione di Genova, I-16146, Genova, Italy

    Andrea Chincarini, Paolo Bosco, Gianluca Gemme, Francesco Sensi, Ilaria Solano & Sandro Squarcia

  2. Medicina Nucleare, Dip. di Medicina Interna e Specialità Mediche Università degli Studi di Genova, Genova, Italy

    Silvia Morbelli

  3. Dipartimento di Fisica, Università degli Studi di Genova, I-16146, Genova, Italy

    Paolo Bosco, Ilaria Solano & Sandro Squarcia

  4. Dipartimento Interateneo di Fisica “M. Merlin” and TIRES, Università degli Studi di Bari, Bari, Italy

    Nicola Amoroso & Sabina Tangaro

  5. INFN, Sezione di Trieste, I-34127, Trieste, Italy

    Renata Longo

  6. Dipartimento di Fisica, Università degli Studi di Trieste, I-34127, Trieste, Italy

    Renata Longo

  7. Neurofisiologia Clinica, Dipartimento di Neuroscienze, Oftalmologia e Genetica, Azienda Ospedale-Università S. Martino, Genova, I-16132, Genova, Italy

    Dario Arnaldi & Flavio Nobili

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  1. Andrea Chincarini
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  2. Paolo Bosco
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  3. Gianluca Gemme
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  4. Silvia Morbelli
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  6. Francesco Sensi
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  7. Ilaria Solano
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  9. Sabina Tangaro
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  10. Renata Longo
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  11. Sandro Squarcia
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  12. Flavio Nobili
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Correspondence to Andrea Chincarini.

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Chincarini, A., Bosco, P., Gemme, G. et al. Alzheimer’s disease markers from structural MRI and FDG-PET brain images. Eur. Phys. J. Plus 127, 135 (2012). https://doi.org/10.1140/epjp/i2012-12135-6

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  • DOI: https://doi.org/10.1140/epjp/i2012-12135-6

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