Abstract
This paper presents the results of an original study devoted to the dynamics of cognitive functions in the population cohort 50 to 85 years of age without neurodegenerative, vascular, or other significant diseases associated with cognitive impairment. It has been shown that memory moderately declines with aging, which is expressed in inadequacy of recollection against a relatively preserved level of memory, and mild executive dysfunctions develop (in planning and control). According to the generally accepted neuropsychological approaches, these age-related cognitive changes emerge due to anterior cortical dysfunctions and/or impaired interaction between the frontal lobes and subcortical basal ganglia. This study has also shown that there are types of age-related physiological changes normally occurring in the area of memory and executive functions, which is clinically important for differential diagnosis to distinguish normal aging from the early stages of cerebral diseases typical of the elderly.
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References
Voznesenskaya, T.G., Emotional-affective and behavioral disorders in mild to moderate cognitive impairment: use of memantine, Nevrol. Zh., 2009, vol. 14, no. 3, pp. 49–54.
Voznesenskaya, T.G., Non-cognitive neuropsychiatric disorders at cognitive impairment in old age, Nevrol. Zh., 2010, vol. 15, no. 2, pp. 4–18.
Drozdova, E.A. and Zakharov, V.V., Cognitive functions in the acute period of the brain concussion, Nevrol. Zh., 2012, vol. 17, no. 2, pp. 15–21.
Zakharov, V.V. and Voznesenskaya, T.G., Nervnopsikhicheskie narusheniya: diagnosticheskie testy (Neuropsychiatric Disorders: Diagnostic Tests), Moscow: MEDpress-Inform, 2014.
Yakhno, N.N. and Lavrov, A.Yu., Izmeneniya tsentral’noi nervnoi sistemy pri starenii: neirodegenerativnye bolezni i starenie. Rukovodstvo dlya vrachei (Changes in the Central Nervous System in Aging: Neurodegenerative Diseases and Aging. Manual for Physicians), Moscow, 2001, pp. 242–261.
Yakhno, N.N., Zakharov, V.V., and Lokshina, A.B., Impairment of memory and attention in the elderly, Neurosci. Behav. Physiol., 2007, vol. 37, no. 3, pp. 203–208.
Allain, P., Berrut, G., Etcharry-Bouyx, F., et al., Executive functions in normal aging: an examination of script sequencing, script sorting, and script monitoring, J. Gerontol., Ser. B, 2007, vol. 62, no. 3, pp. 187–190.
Bonelli, R.M. and Cummings, J.L., Frontal-subcortical dementia, Neurologist, 2008, vol. 14, no. 2, pp. 100–107.
Di Paola, M., Macaluso, E., Carlesimo, G., et al., Episodic memory impairment in patients with Alzheimer’s disease is correlated with enthorhinal cortex atrophy: a voxel-based morphometry study, J. Neurol., 2007, vol. 254, no. 6, pp. 774–778.
Dubois, B., Slachevsky, A., Litvan, I., and Pillon, B., The FAB: a frontal assessment battery at bedside, Neurology, 2000, vol. 55, pp. 1621–1626.
Fama, R. and Sullivan, E.V., Thalamic structures and associated cognitive functions: relations with age and aging, Neurosci. Biobehav. Rev., 2015, vol. 54, pp. 29–37.
Folstein, M.F., Folstein, S.E., and McHugh, P.R., Mini-mental state: a practical guide for grading the mental state of patients for the clinician, J. Psychiatr. Res., 1975, vol. 12, pp. 189–198.
Grober, E., Bushke, H., Crystal, H., et al., Screening for dementia by memory testing, Neurology, 1988, vol. 38, pp. 900–903.
Kirova, A.-M., Bays, R.B., and Lagalwar, S., Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer’s disease, BioMed. Res. Int., 2015, vol. 2015, art. ID 748212. doi 10.1155/2015/74821
Kopelman, M.D., Amnesia: organic and psychogenic, Br. J. Psychiatry, 1987, vol. 150, pp. 428–442.
Peters, R., Ageing and the brain, Postgrad. Med. J., 2006, vol. 82, no. 964, pp. 84–88.
Pillon, B., Deweer, B., Agid, Y., and Dubois, B., Explicit memory in Alzheimer’s, Hungtington’s and Parkinson’s diseases, Arch. Neurol., 1993, vol. 50, pp. 374–379.
Pillon, B., Deweer, B., Michon, A., et al., Are explicit memory disorder of progressive supranuclear palsy related to damage to striatofrontal circuits? Comparison with Alzheimer’s disease, Parkinson’s disease and Huntington’s disease, Neurology, 1994, vol. 44, no. 7, pp. 1264–1269.
Sarazin, M., Berr, C., De Rottrou, J., et al., A syndrome of medial temporal type identifies prodromal Alzheimer’s disease: a longitudinal study, Neurology, 2007, vol. 69, no. 19, pp. 1859–1864.
Sarazin, M., Chauvire, V., Gerardin, E., et al., The amnestic syndrome of hippocampal type in Alzheimer’s syndrome: an MRI study, J. Alzheimer’s Dis., 2010, vol. 22, no. 1, pp. 285–294.
Sweeney, J.A., Rosano, C., Berman, R.A., and Luna, B., Inhibitory control of attention declines more than working memory during normal aging, Neurobiol. Aging, 2001, vol. 22, no. 1, pp. 39–47.
Sylvain-Roy, S., Lungu, O., and Belleville, S., Normal aging of the attentional control functions that underlie working memory, J. Gerontol., B, 2015, vol. 70, no. 5, pp. 698–708.
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Original Russian Text © V.V. Zakharov, I.Yu. Savushkina, E.A. Mkhitaryan, N.N. Koberskaya, A.B. Lokshina, D.A. Grishina, C.I. Posokhov, A.V. Tarapovskaya, N.N. Yakhno, 2017, published in Uspekhi Gerontologii, 2017, Vol. 30, No. 3, pp. 450–456.
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Zakharov, V.V., Savushkina, I.Y., Mkhitaryan, E.A. et al. Age-Related Dynamics of Cognitive Functions in Persons Aged 50–85 Years. Adv Gerontol 8, 41–46 (2018). https://doi.org/10.1134/S2079057018010137
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DOI: https://doi.org/10.1134/S2079057018010137