A cyclic feeding regime: A new model in experimental gerontology
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The influence of a specific cyclic feeding regime (CFR) which provided a 30% loss of body weight in 14 days and its recovery in 14 days followed by the standard feeding diet over the course of 30 days on the rat lifespan was investigated. It was shown that young and old animals differed in the intensities of loss and recovery of body weight after three cycles of CFR. The mass of the liver changed cyclically as well as the body weight. It was found that the content of glucose and protein in serum cyclically changed only in the first cycle of CFR; a completely different trend of these parameters was observed during the second cycle of the same feeding regime. Such dynamics in response to repetitive exposures of the same type indicates a change in adaptation strategies and the usage of alternative metabolic pathways that provide survival in extreme conditions. Each subsequent cycle of weight loss-recovery differed from the previous one and had a pronounced age-related character. Animals that successfully underwent three consecutive CFRs after the age of 19 months had a longer lifespan as compared to the control group. CFR can be used as a new model in gerontology providing increased lifespan when not only young but also old animals are transferred to the diet.
Keywordscyclic feeding regime age lifespan
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