Abstract
Basic parameters of the immune status of relatively healthy people of different ages that live in the monsoon climate in the southern part of the Russian Far East have been considered. This data analysis has shown that the development of an immunodepressive condition in combination with increasing amounts of CD 16, CD 25, and HLA-DR is age-dependent and progresses together with aging. The aggressiveness of climatic, geographical, and anthropogenic factors has a deep damaging impact, which results in the degree of manifestation of functional immune disorders among elderly people, older adults, and long-lived people.
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References
Anisimov, V.N., Senescence and Age-Related Diseases, Klin. Gerontol., 2005, no. 1, pp. 42–49.
Anisimov, V.N., Molekulyarnye i fiziologicheskie mekhanizmy stareniya (Molecular and Physiological Mechanisms of Senescence), St. Petersburg: Nauka, 2008.
Vitkina, T.I., Kosolapov, A.B., and Kiku, P.F., Ekologicheskie aspekty rasprostraneniya immunopatologii na Dal’nem Vostoke (Ecological Aspects of Immunopathology Distribution in the Far East), Vladivostok: DVGAEU, 2001.
Dontsov, V.I., Trukhanov, A.I., and Krut’ko, V.N., Meditsina antistareniya: fundamental’nye osnovy (Medicine of Antisenescence: Fundamental Principles), Moscow: URSS, 2010.
Il’nitskii, A.N., Modern Tendencies in Geriatric Rehabilitation, in Perspektivy fundamental’noi gerontologii: Tezisy dokl. Vseros. konf. (All-Russian Conference on Perspectives of Fundamental Gerontology, Abstract of Papers), St. Petersburg, 2006, pp. 46–48.
Kaznacheev, S.V., Study Methods of Anthropogenic and Ecological Systems at the Individual and Organism Levels in Biology and Medicine, in Ekologiya cheloveka: osnovnye problemy (Human Ecology: General Problems), Moscow: Nauka, 1988, pp. 170–176.
Parakhonskii, A.P., Principles of Formation of the Normal Immunological Parameters, Uspekhi Sovrem. Estestvozn., 2008, no. 7, pp. 63–64.
Potapov, V.N. and Kapshienko, I.N., Immunobiological Aspects of Phenotypical Adaptation of a Man to Ecological Conditions of the South Far East, Byul. Akad. Med. Nauk, 1993, no. 1, pp. 40–45.
Semenkov, V.F., Karandashov, V.I., and Koval’chuk, L.V., Immunogerontologiya: Ruk. dlya vrachei (Immunology: Manual for Doctors), Moscow: Meditsina, 2005.
Struchkov, P.V., Konstantinova, N.A., Lavrent’ev, V.V., and Chuchalin, A.G., Screening-Test for Evaluation of Pathogenic Properties of Circulating Immune Complexes, Lab. Delo, 1985, no. 7, pp. 410–412.
Tagdisi, D.G., Mamedov, Ya.D., and Aliev, S.D., Staraya novaya nauka (Old New Science), Moscow: Znanie, 1989.
Khaitov, R.M., Yarilin, A.A., and Pinegin, B.V., Rukovodstvo po klinicheskoi immunologii: immunodiagnostika zabolevanii immunnoi sistemy (Manual on Clinical Immunology: Immunological Diagnostics of Immune System Diseases), Moscow: GEOTAR-Media, 2009.
Shmelev, E.V., Bumagina, G.K., and Miterov, P.P., Modified Parks’ Method, Lab. Delo, 1979, no. 9, pp. 13–15.
Yarygin, V.N. and Melent’ev, A.S., Rukovodstvo po gerontologii i geriatrii: Klinicheskaya geriatriya (Manual on Gerontology and Geriatrics: Clinical Geriatrics), Moscow: GEOTAR-Media, vol. 2, 2007.
Mancini, G. and Heremans, J.S., Immunochemical Quantitation of Antigen by Simple Radial Immunodiffusion, Immunochemistry, 1965, vol. 2, no. 3, pp. 235–254.
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Original Russian Text © T.A. Gvozdenko, O.Yu. Kytikova, T.I. Vitkina, P.V. Borshchyov, 2012, published in Uspekhi Gerontologii, 2012, Vol. 25, No. 1, pp. 68–71.
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Gvozdenko, T.A., Kytikova, O.Y., Vitkina, T.I. et al. Description of the immune system of residents of the Russian Far East during physiological aging. Adv Gerontol 2, 319–322 (2012). https://doi.org/10.1134/S207905701204008X
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DOI: https://doi.org/10.1134/S207905701204008X