Advances in Gerontology

, Volume 2, Issue 3, pp 221–229 | Cite as

Effect of phenol inducing antioxidant responsive element on D. melanogaster lifespan

  • N. Ya. Weisman
  • E. B. Men’shchikova
  • N. K. Zenkov
  • N. V. Kandalintseva
  • M. D. Golubovsky
Article

Abstract

The effect of hydrophilic synthetic antioxidant TS-13 (sodium 3-(3′-tert-butyl-4′-hydroxyphenyl)propyl thiosulfonate) on the lifespan of different lines of Drosophila melanogaster under normal conditions and the survival in the oxidative stress induced by hydrogen peroxide and paraquat were studied. The addition of 1% TS-13 to diets extended the lifespan of males and females of the long-living Canton S line of D. melanogaster, had no effect on the lifespan of short-living Oregon R line and shortened the average lifespan of males of the lgl 558 OR/Cy line of D. melanogaster containing a heterozygous recessive lethal mutation of tumor suppressor. Under the conditions of oxidative stress induced by hydrogen peroxide, TS-13 increased the survival of Canton S males and Oregon R females; under the action of paraquat, the protective effect of antioxidant was manifested toward Canton S females and Oregon R flies of both sexes. Despite the fact that anti-aging and protective properties of synthetic phenolic antioxidant TS-13 strongly depend on the genotype and gender, under extreme conditions of oxidative stress. its positive effect is pronounced.

Keywords

lifespan Drosophila melanogaster oxidative stress phenol antioxidan 

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • N. Ya. Weisman
    • 1
  • E. B. Men’shchikova
    • 2
  • N. K. Zenkov
    • 2
  • N. V. Kandalintseva
    • 3
  • M. D. Golubovsky
    • 4
  1. 1.Institute of Cytology and Genetics, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  2. 2.Scientific Center of Clinical and Experimental Medicine, Siberian BranchRussian Academy of Medical SciencesNovosibirskRussia
  3. 3.Novosibirsk State Pedagogical UniversityNovosibirskRussia
  4. 4.Department of Molecular and Cell BiologyUniversity of CaliforniaBerkeleyUSA

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