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Relationship between endothelial and myocardial dysfunction in elderly patients with arterial hypertension

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Abstract

To identify the clinical and instrumental features of the relation of endothelial (ED) and myocardial (MD) dysfunctions in elderly persons with arterial hypertension (AH), 66 patients of 60–74 years of age, suffering from hypertension stage II and 26 of the same age without cardiovascular disease were examined. It is established that the development of hypertension against ED is accompanied by the formation of the concentric hypertrophy and concentric myocardial remodeling, diastolic and systolodiastolic MD, and its severity is conjugated with the severity of endothelial dysfunction. Progression of ED is accompanied by disorders of metabolism of lipids, higher intensity of their peroxidation, and decreasing efficiency of antioxidant protection mechanisms.

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Authors and Affiliations

  1. Kursk State Medical University, ul. K. Marksa 3, Kursk, 305041, Russia

    N. K. Gorshunova, N. V. Medvedev, D. N. Ukraintseva & S. S. Mauer

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  1. N. K. Gorshunova
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  2. N. V. Medvedev
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  3. D. N. Ukraintseva
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  4. S. S. Mauer
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Correspondence to N. K. Gorshunova.

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Original Russian Text © N.K. Gorshunova, N.V. Medvedev, D.N. Ukraintseva, S.S. Mauer, 2011, published in Uspekhi Gerontologii, 2011, Vol. 24, No. 3, pp. 478–484.

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Gorshunova, N.K., Medvedev, N.V., Ukraintseva, D.N. et al. Relationship between endothelial and myocardial dysfunction in elderly patients with arterial hypertension. Adv Gerontol 2, 153–158 (2012). https://doi.org/10.1134/S2079057012020087

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