Abstract
In this paper, the expression of IL-6 cytokine in kidney biopsy tissue of IgA-nephropathy patients of different age groups was analyzed and its correlation with the clinical and morphological picture of the disease was investigated. In the study it was shown that IL-6 affects the formation of histopathological changes of kidney tissue and this process has no dependence on the patient’s age. Given that the duration of the disease influences the level of IL-6 expression in the glomerulus regardless of the patient’s age, the role of IL-6 in the disease development was confirmed.
Similar content being viewed by others
References
Rakityanskaya, I.A., Immunopathogenetic Mechanisms of Development and Progress Glomerulonephritis, in Nefrologiya: Ruk. dlya vrachei (Nephrology: Manual for Doctors), Ryabov, S.I., Ed., St. Petersburg: Spetslit, 2000, pp. 37–69.
Ryabov, S.I. and Rakityanskaya, I.A., Role Mononuklears in Nephron in Patients with Chronic Glomerulonephritis, Message II: Role of Interleukines (IL-6 and IL-10) and Proliferation of Glomerular and Interstitial Cellsof Nephron at Development of Mesangium-Proliferative Glomerulonephritis, Nefrologiya, 1998, vol. 2, no. 2, pp. 30–36.
Anders, H.-J., Banas, B., and Schlöndorff, D., Signaling Danger: Toll-Like Receptors and Their Potential Roles in Kidney Disease, J. Amer. Soc. Nephrol., 2004, vol. 15, pp. 854–867.
Bantis, C., Heering, P., Aker, S., et al., Influence of Cytokine Gene Polymorphisms on IgA Nephropathy, Ren Fail., 2008, vol. 30, no. 2, pp. 135–140.
Boswell, R.N., Yard, B.A., Schrama, E., et al., Interleukin 6 Production by Human Proximal Tubular Epithelial Cells in Vitro: Analysis of the Effects of Interleukin-1 Alpha (IL-1 Alpha) and Other Cytokines, Nephrol. Dial Transplant., 1994, vol. 9, no. 6, pp. 599–606.
Bruunsgaard, H., Pedersen, M., and Pedersen, B.K., Aging and Proinflammatory Cytokines, Curr. Opin. Hemat., 2001, vol. 8, no. 3, pp. 131–136.
Buraczynska, M., Jozwiak, L., Ksiazek, P., et al., Interleukin-6 Gene Polymorphism and Faster Progression to End-Stage Renal Failure in Chronic Glomerulonephritis, Transplant. Res. 2007, vol. 150, no. 2, pp. 101–105.
De Martinis, M., Franceschi, C., Monti, D., and Ginaldi, L., Inflammageing and Lifelong Antigenic Load as Major Determinants of Aging Rate and Longevity, FEBS Lett., 2005, vol. 579, pp. 2035–2039.
Fonseca, J. E., Santos, M. J., Canhão, H., and Choy, E., Interleukin-6 as a Key Player in Systemic Inflammation and Joint Destruction, Autoimmun. Rev., 2009, vol. 8, no. 7, pp. 538–542.
Haradaa, K., Akaia, Y., Kurumatani, N., et al., Prognostic Value of Urinary Interleukin 6 in Patients with IgA Nephropathy: An 8-Year Follow-Up Study, Nephron., 2002, vol. 92, no. 4, pp. 824–826.
Kawai T. and Akira, S., TLR Signaling, Seminars Immunol., 2007, vol. 19, pp. 24–32.
Leonard, M., Ryan, M.P., Watson, A.J., et al., Role of MAP Kinase Pathways in Mediating IL-6 Production in Human Primary Mesangial and Proximal Tubular Cells, Kidn. Int., 1999, vol. 56, no. 4, pp. 1366–1377.
Licastro, F., Candore, G., Lio, D., et al., Innate Immunity and Inflammation in Ageing: A Key for Understanding Age-Related Diseases, Immunol. Aging, 2005, vol. 2, p. 8.
Lim, C.S., Kim, Y.S., Ahn, C.R., et al., Intrarenal Expression of Interleukin-6 and the -174 G/C Polymorphism in IgA Nephropathy, Korean J. Nephrol., 2002, vol. 21, no. 4, pp. 595–601.
Maksić, D.J., Dimitrijević, J., Spasić, P., et al., Correlation of Inflammatory Cytokines in the Urine and Serum with Clinico-Laboratory and Pathohistologic Features in Patients with IgA Nephropathy, Srp. Arh. Celok Lek., 1996, vol. 124, suppl. 1, pp. 37–40.
Noronha, I.L., Niemir, Z., Stein, H., and Waldherr, R., Cytokines and Growth Factors in Renal Disease, Nephrol. Dial. Transplant., 1995, vol. 10, no. 6, pp. 775–786.
O’Neill, L.A. and Bowie, A.G., The Family of Five: TIR-Domain-Containing Adaptors in Toll-Like Receptor Signaling, Nat. Rev. Immunol., 2007, vol. 7, no. 5, pp. 353–364.
Rostoker, G., Rymer, J.-C., Bagnard, G., et al., Imbalances in Serum Proinflammatory Cytokines and Their Soluble Receptors: A Putative Role in the Progression of Idiopathic IgA Nephropathy (IgAN) and Henoch-Schönlein Purpura Nephritis, and a Potential Target of Immunoglobulin Therapy? Clin. Exp. Immunol., 1998, vol. 114, no. 3, pp. 468–476.
Ruef, C., Budde, K., Lacy, J., et al., Interleukin 6 is an Autocrine Growth Factor for Mesangial Cells, Kidn. Int., 1990, vol. 38, no. 2, pp. 249–57.
Schena, F.P., Gesualdo, L., Grandaliano, G., and Montinaro, V., Progression of Renal Damage in Human Glomerulonephritides: Is There Sleight of Hand in Winning the Game? Kidn. Int., 1997, vol. 52, pp. 1439–1457.
Smith, K.D., Lipchock, S.V., Ames, T.D., et al., Structural Basis of Ligand Binding by a C-Di-GMP Riboswitch, Nat. Struct. Mol. Biol., 2009, vol. 16, no. 12, pp. 1218–1223.
Sterzel, R.B., Schulze-Lohoff, E., and Marx, M., Cytokines and Mesangial Cells, Kidn. Int., 1993, vol. 39, pp. 26–31.
Taniguchi, Y., Yorioka, N., Oda, H., Yamakido, M., Platelet-Derived Growth Factor, Interleukin (IL)-1 Beta, IL-6R and Tumor Necrosis Factor-Alpha in IgA Nephropathy: An Immunohistochemical Study, Nephron, 1996, vol. 74, no. 4, pp. 652–660.
Van den Biggelaar, A.H., Huizinga, T.W., De Craen, A.J., et al., Impaired Innate Immunity Predicts Frailty in Old Age. The Leiden 85-Plus Study, Exp. Geront., 2004, vol. 39, pp. 1407–1414.
Wadaa, J., Sugiyamaa, H., Makino, H., Pathogenesis of IgA Nephropathy, Seminars Nephrol., 2003, no. 6, pp. 556–563.
Wagner, H., The Immunobiology of the TLR9 Subfamily, Trends Immunol., 2004, vol. 25, pp. 381–386.
Yano, N., Endoh, M., Nomoto, Y., et al., Phenotypic Characterization of Cytokine Expression in Patients with IgA Nephropathy, J. Clin. Immunol., 1997, vol. 17, no. 5, pp. 396–403.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © T.S. Ryabova, I.A. Rakityanskaya, 2011, published in Uspekhi Gerontologii, 2011, Vol. 24, No. 2, pp. 244–248.
Rights and permissions
About this article
Cite this article
Ryabova, T.S., Rakityanskaya, I.A. The effects of IL-6 cytokine expression in renal tissue on the clinical and morphological picture of IgA-nephropathy in patients over 60 years old. Adv Gerontol 2, 60–64 (2012). https://doi.org/10.1134/S2079057012010122
Published:
Issue Date:
DOI: https://doi.org/10.1134/S2079057012010122