The effects of IL-6 cytokine expression in renal tissue on the clinical and morphological picture of IgA-nephropathy in patients over 60 years old
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In this paper, the expression of IL-6 cytokine in kidney biopsy tissue of IgA-nephropathy patients of different age groups was analyzed and its correlation with the clinical and morphological picture of the disease was investigated. In the study it was shown that IL-6 affects the formation of histopathological changes of kidney tissue and this process has no dependence on the patient’s age. Given that the duration of the disease influences the level of IL-6 expression in the glomerulus regardless of the patient’s age, the role of IL-6 in the disease development was confirmed.
KeywordsIgA-nephropathy interleukin-6 biopsy tissue age
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- 1.Rakityanskaya, I.A., Immunopathogenetic Mechanisms of Development and Progress Glomerulonephritis, in Nefrologiya: Ruk. dlya vrachei (Nephrology: Manual for Doctors), Ryabov, S.I., Ed., St. Petersburg: Spetslit, 2000, pp. 37–69.Google Scholar
- 2.Ryabov, S.I. and Rakityanskaya, I.A., Role Mononuklears in Nephron in Patients with Chronic Glomerulonephritis, Message II: Role of Interleukines (IL-6 and IL-10) and Proliferation of Glomerular and Interstitial Cellsof Nephron at Development of Mesangium-Proliferative Glomerulonephritis, Nefrologiya, 1998, vol. 2, no. 2, pp. 30–36.Google Scholar
- 7.Buraczynska, M., Jozwiak, L., Ksiazek, P., et al., Interleukin-6 Gene Polymorphism and Faster Progression to End-Stage Renal Failure in Chronic Glomerulonephritis, Transplant. Res. 2007, vol. 150, no. 2, pp. 101–105.Google Scholar
- 14.Lim, C.S., Kim, Y.S., Ahn, C.R., et al., Intrarenal Expression of Interleukin-6 and the -174 G/C Polymorphism in IgA Nephropathy, Korean J. Nephrol., 2002, vol. 21, no. 4, pp. 595–601.Google Scholar
- 18.Rostoker, G., Rymer, J.-C., Bagnard, G., et al., Imbalances in Serum Proinflammatory Cytokines and Their Soluble Receptors: A Putative Role in the Progression of Idiopathic IgA Nephropathy (IgAN) and Henoch-Schönlein Purpura Nephritis, and a Potential Target of Immunoglobulin Therapy? Clin. Exp. Immunol., 1998, vol. 114, no. 3, pp. 468–476.PubMedCrossRefGoogle Scholar
- 22.Sterzel, R.B., Schulze-Lohoff, E., and Marx, M., Cytokines and Mesangial Cells, Kidn. Int., 1993, vol. 39, pp. 26–31.Google Scholar
- 25.Wadaa, J., Sugiyamaa, H., Makino, H., Pathogenesis of IgA Nephropathy, Seminars Nephrol., 2003, no. 6, pp. 556–563.Google Scholar