Simulation of drosophila aging in silico

  • V. A. Chistyakov
  • Yu. V. Denisenko


One of the main tasks of modern gerontology is isolation of a group of phenomena essential for aging from epiphenomenona accompanying them. The modern methods of simulation modeling may be the proper tool for correct isolation. The point of their application is reproduction of external aging manifestations in silico, and, in the first place, of standard survival curves with the help of the simplest internal mechanism. It seems that such a mechanism will be prime mover of aging. The aging model of one the most popular objects of experimental biology—a fruit fly(Drosophila melanogaster) created by us (, is based on the assumption that the key mechanism of aging is cellularity loss, the speed of which is determined by the parameters of active oxygen forms generation in motoneurons.


simulation modeling age cellularity loss motoneuron apoptosis aging hit 


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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.The Research Institute of Biology of Southern Federal UniversityRostov-On-DonRussia

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