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The features of development of osteoporosis in senescence-accelerated OXYS rats

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Abstract

Osteoporosis in OXYS rats is one of the signs of their accelerated aging. Previously, we regarded it as senile. However, in this study osteoporotic changes in the metabolism of OXYS rats have been revealed in the early postnatal period. They may lead to the development of osteoporosis in the future and may underlie the formation of a reduced peak bone mass. One hundred and eighty OXYS and Wistar (the control group) rats aged from 10 days to 24 months have been used in this study. No differences in the bone mineral density (BMD) in OXYS and Wistar rats at the age of 10 days and 3 months were observed. On the tenth day, the activity of alkaline phosphatase (ALP), a marker of osteoblast activity, was maximum in both OXYS and Wistar rats. However, OXYS rats showed an activity 40% higher than Wistar rats. With age, ALP activity decreased and after 3 months it was half in OXYS rats than it was in Wistar rats. The peak bone mass in Wistar rats is formed by the age of 12 months, and in OXYS rats it is formed already by 6 months, but it does not reach the level of the Wistar rats. The content of calcium (Ca) in the blood and bone tissue changes similarly. In OXYS rats after 6 months, it decreased simultaneously with Ca. The bone phosphorus (P) was the same in both groups, and the bone strontium (Sr) was lower in OXYS rats aged 6 and 12 months. Nevertheless, these changes in the mineral composition of bone in OXYS rats did not affect their mechanical strength. The absolute strength of the long bones in OXYS rats aged 12 months was lower than that of Wistar rats. However, this is due to a decrease by 1.7 times in cross-sectional area and the standardization per area unit neutralizes the difference. We found that OXYS rats demonstrate a genetically determined hypoplasia of the bone tissue, which may be associated with the development of idiopathic osteoporosis.

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References

  1. Ershov, K.I., Rusova, T.V, Falameeva, O.V., et al., Bone Matrix Glycosaminoglycans and Osteoporosis Development in Early Aging OXYS Rats, Usp. Gerontologii, 2009, vol. 22, no. 2, pp. 285–291.

    CAS  Google Scholar 

  2. Kolosova, N.G., Kutorgin, G.D., and Safina, A.F., Peculiarities of the Bone Tissue Mineralization in Prematurely Ageing OXYS Rats, Byull. Eksper. Biol. i Med., 2002, vol. 133, pp. 203–206.

    Google Scholar 

  3. Lesnyak, O.M., Benevolenskaya, L.I., Klinicheskie Rekomendatsii. Osteoporoz: Diagnostika, Profilaktika i lechenie (Health school. Osteoporosis. Guidelines for Physicians), Moscow: GEOTAR-Media, 2009.

    Google Scholar 

  4. Mikhailov, E.E., Benevolenskaya, L.I., and Mylov, N.M., The Frequency of New Vertebral Fractures in the Population Sample of People Aged 50 Years and Older, Vestn. Travmatol. i Ortopedii im. N.N. Priorova, 1997, no. 3, pp. 20–27.

  5. Falameeva, O.V., Sadovaya, M.A., Khrapova, Yu. V., and Kolosova, N. G., Structural and Functional Changes in Bone Tissue of the Spine and Extremities in OXYS rats, Khirurgiya Pozvonochnika, 2006, vol. 1, pp. 88–94.

    Google Scholar 

  6. Atkins, G.J., Welldon, K.J., Halbout, P., and Findlay, D.M., Strontium Ranelate Treatment of Human Primary Osteoblasts Promotes an Osteocyte-like Phenotype while Eliciting an Osteoprotegerin Response, Osteoporos Int., 2009, vol. 20, no. 4, pp. 653–664.

    Article  CAS  PubMed  Google Scholar 

  7. Baroncelli, G.I. and Saggese, G., Critical Ages and Stages of Puberty in the Accumulation of Spinal and Femoral Bone Mass: the Validity of Bone Mass Measurements, Horm. Res., 2000, vol. 54, no. 1 (suppl.), p. 2.

    CAS  PubMed  Google Scholar 

  8. Bolscher, M.D., Netelenbos, J.C., Barto, R., and Van der Vijgh, W.J.F., Strontium as a Marker for Intestinal Calcium Abcorption: the Stimulatory Affect of Calcitriol Clin. Chem., 2000, vol. 46, no. 2., pp. 248–251.

    Google Scholar 

  9. Boot, A.M., Ridder, M.A., Sluis, I.M., et al., Peak Bone Mineral Density, Lean Body Mass and Fractures., Bone, 2010, vol. 46, no. 2, pp. 336–341.

    Article  PubMed  Google Scholar 

  10. Brennan, T.C., Rybchyn, M.S., Green, W., et al., Osteoblasts Play Key Roles in the Mechanisms of Action of Strontium Ranelate, Brit. J. Pharmacol., 2009, vol. 157, no. 7, pp. 1291–1300.

    Article  CAS  Google Scholar 

  11. Castaneda, S., Calvo, E., Largo, R., et al., Characterization of a New Experimental Model of Osteoporosis in Rabbits, J. Bone Miner. Metab., 2008, vol. 26, pp. 53–59.

    Article  CAS  PubMed  Google Scholar 

  12. Dempster, D.W., Anatomy and Functions of the Adult Skeleton. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Sixth Edition, Favus M.J., et al. Eds., Amer. Soc. for Bone and Mineral Research. Washington, USA, 2006, pp. 7–11.

  13. Downey, P.A. and Siegel, M.I., Bone Biology and the Clinical Implications for Osteoporosis, Physiol. Ther., 2006, vol. 1, pp. 77–91.

    Google Scholar 

  14. Duque, G. and Troen, B.R., Understanding the Mechanisms of Senile Osteoporosis: New Facts for a Major Geriatric Syndrome J. Amer. Geriat. Soc., 2008, vol. 56, no. 5, pp. 935–941.

    Article  PubMed  Google Scholar 

  15. Fukuda, S. and Iida, H., Age-related Changes in Bone Mineral Density, Cross-sectional Area and the Strength of Long Bones in the Hind Limbs and First Lumbar Vertebra in Female Wistar Rats, J. Vet. Med. Sci., 2004, vol. 66, no.7, pp. 755–760.

    Article  Google Scholar 

  16. Gonchar, A., Kolmogorov, U., Gladkikh, E., et al., The Estimation of Possibilities of Synchrotron Radiation, X-ray Fluorescent Analysis, and Atomic Spectrometry for the Bone’s Elemental Composition Determination, Nucl. Instr. Method. Phys. Res., 2005, vol. 543, pp. 271–273.

    Article  CAS  Google Scholar 

  17. Johnell, O. and Kanis, J., Epidemiology of Osteoporotic Fractures, Osteoporos Int., 2005, vol. 16, no. 2 (suppl.), pp. 3–7.

    Article  Google Scholar 

  18. Lee, A. J., Hodges S., and Eastell, R., Measurement of Osteocalcin, Ann. Clin. Biochem., 2000, vol. 37, no. 4, pp. 432–446.

    Article  PubMed  Google Scholar 

  19. Lorenc, R.S., Idiopathic Juvenile Osteoporosis, Calcif Tiss. Int., 2002, vol. 70, no. 5, pp. 395–397.

    Article  CAS  Google Scholar 

  20. Nielsen, S.P., The Biological Role of Strontium, Bone, 2004, vol. 35, pp. 583–588.

    Article  Google Scholar 

  21. Pietschmann P., Rauner, M., Sipos, W., and Kerschan-Schindl, K., Osteoporosis: An Age-related and Gender-specific Disease; a Mini-review, Gerontology, 2008, vol. 55, no. 1, pp. 3–12.

    Article  PubMed  Google Scholar 

  22. Rector, R.S., Loethen J., Ruebel, M., et al., Serum Markers of Bone Turnover are Increased by Modest Weight Loss with or without Weight-bearing Exercise in Overweight Premenopausal Women, Appl. Physiol. Nutr. Metab., 2009. vol. 34, no. 5, pp. 933–941.

    Article  CAS  PubMed  Google Scholar 

  23. Saggese, G., Baroncelli, G.I., and Bertelloni, S., Puberty and Bone Development, Best Pract. Res. Clin. Endocr. Metab., 2002, vol. 16, no. 1, pp. 53–64.

    Article  CAS  Google Scholar 

  24. Sato, Y., Honda, Y., Asoh, T., and Iwamoto, J., Longitudinal Study of Bone and Calcium Metabolism and Fracture Incidence in Spinocerebellar Degeneration Europ. Neurol., 2006, vol. 56, no. 3, pp. 155–161.

    Article  PubMed  Google Scholar 

  25. Singer, F.R. and Eyre, D.R., Using Biochemical Markers of Bone Turnover in Clinical Practice, Cleve Clin. J. Med., 2008, vol. 75, no. 10, pp. 739–750.

    Article  PubMed  Google Scholar 

  26. Talmage, D.W., and Talmage, R.V., Calcium Homeostasis: How Bone Solubility Relates to All Aspects of Bone Physiology, J. Musculoskelet Neuronal. Interact., 2007, vol. 7, no. 2, pp. 108–112.

    CAS  PubMed  Google Scholar 

  27. Venediktova, A.A., Falameeva, O.V., Kolosova, N.G., et al., Cathepsin K and Matrix Metalloprotease Activities in Bone Tissue of the OXYS Rats During the Development of Osteoporosis, Biomed. Chem., 2009, vol. 3, no. 4, pp. 393–398.

    Google Scholar 

  28. WHO Assessment of Fracture Risk and its Application to Screening for Postmenopausal Osteoporosis: Report of a WHO Study Group in WHO Technical Report Series 843, WHO, Geneva, 1994.

    Google Scholar 

  29. Williams, R.J.P., The Evolution of Calcium Biochemistry, Biochim. Biophys. Acta., 2006, vol. 1763, pp. 1139–1146.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Lavrent’eva 10, Novosibirsk, 630090, Russia

    N. A. Muraleva & N. G. Kolosova

  2. Research Institute of Traumatology and Orthopedics, ul. Frunze 17, Novosibirsk, 630091, Russia

    N. A. Muraleva & M. A. Sadovoy

Authors
  1. N. A. Muraleva
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  2. M. A. Sadovoy
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  3. N. G. Kolosova
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Correspondence to N. G. Kolosova.

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Original Russian Text © N.A. Muraleva, M.A. Sadovoy, N.G. Kolosova, 2010, published in Uspekhi Gerontologii, 2010, Vol. 23, No. 2, pp. 233–242.

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Muraleva, N.A., Sadovoy, M.A. & Kolosova, N.G. The features of development of osteoporosis in senescence-accelerated OXYS rats. Adv Gerontol 1, 171–178 (2011). https://doi.org/10.1134/S2079057011020111

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