The features of development of osteoporosis in senescence-accelerated OXYS rats
- 20 Downloads
Osteoporosis in OXYS rats is one of the signs of their accelerated aging. Previously, we regarded it as senile. However, in this study osteoporotic changes in the metabolism of OXYS rats have been revealed in the early postnatal period. They may lead to the development of osteoporosis in the future and may underlie the formation of a reduced peak bone mass. One hundred and eighty OXYS and Wistar (the control group) rats aged from 10 days to 24 months have been used in this study. No differences in the bone mineral density (BMD) in OXYS and Wistar rats at the age of 10 days and 3 months were observed. On the tenth day, the activity of alkaline phosphatase (ALP), a marker of osteoblast activity, was maximum in both OXYS and Wistar rats. However, OXYS rats showed an activity 40% higher than Wistar rats. With age, ALP activity decreased and after 3 months it was half in OXYS rats than it was in Wistar rats. The peak bone mass in Wistar rats is formed by the age of 12 months, and in OXYS rats it is formed already by 6 months, but it does not reach the level of the Wistar rats. The content of calcium (Ca) in the blood and bone tissue changes similarly. In OXYS rats after 6 months, it decreased simultaneously with Ca. The bone phosphorus (P) was the same in both groups, and the bone strontium (Sr) was lower in OXYS rats aged 6 and 12 months. Nevertheless, these changes in the mineral composition of bone in OXYS rats did not affect their mechanical strength. The absolute strength of the long bones in OXYS rats aged 12 months was lower than that of Wistar rats. However, this is due to a decrease by 1.7 times in cross-sectional area and the standardization per area unit neutralizes the difference. We found that OXYS rats demonstrate a genetically determined hypoplasia of the bone tissue, which may be associated with the development of idiopathic osteoporosis.
Keywordsosteoporosis markers of osteoporosis mineral bone density OXYS rats
Unable to display preview. Download preview PDF.
- 1.Ershov, K.I., Rusova, T.V, Falameeva, O.V., et al., Bone Matrix Glycosaminoglycans and Osteoporosis Development in Early Aging OXYS Rats, Usp. Gerontologii, 2009, vol. 22, no. 2, pp. 285–291.Google Scholar
- 2.Kolosova, N.G., Kutorgin, G.D., and Safina, A.F., Peculiarities of the Bone Tissue Mineralization in Prematurely Ageing OXYS Rats, Byull. Eksper. Biol. i Med., 2002, vol. 133, pp. 203–206.Google Scholar
- 3.Lesnyak, O.M., Benevolenskaya, L.I., Klinicheskie Rekomendatsii. Osteoporoz: Diagnostika, Profilaktika i lechenie (Health school. Osteoporosis. Guidelines for Physicians), Moscow: GEOTAR-Media, 2009.Google Scholar
- 4.Mikhailov, E.E., Benevolenskaya, L.I., and Mylov, N.M., The Frequency of New Vertebral Fractures in the Population Sample of People Aged 50 Years and Older, Vestn. Travmatol. i Ortopedii im. N.N. Priorova, 1997, no. 3, pp. 20–27.Google Scholar
- 5.Falameeva, O.V., Sadovaya, M.A., Khrapova, Yu. V., and Kolosova, N. G., Structural and Functional Changes in Bone Tissue of the Spine and Extremities in OXYS rats, Khirurgiya Pozvonochnika, 2006, vol. 1, pp. 88–94.Google Scholar
- 8.Bolscher, M.D., Netelenbos, J.C., Barto, R., and Van der Vijgh, W.J.F., Strontium as a Marker for Intestinal Calcium Abcorption: the Stimulatory Affect of Calcitriol Clin. Chem., 2000, vol. 46, no. 2., pp. 248–251.Google Scholar
- 12.Dempster, D.W., Anatomy and Functions of the Adult Skeleton. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Sixth Edition, Favus M.J., et al. Eds., Amer. Soc. for Bone and Mineral Research. Washington, USA, 2006, pp. 7–11.Google Scholar
- 13.Downey, P.A. and Siegel, M.I., Bone Biology and the Clinical Implications for Osteoporosis, Physiol. Ther., 2006, vol. 1, pp. 77–91.Google Scholar
- 27.Venediktova, A.A., Falameeva, O.V., Kolosova, N.G., et al., Cathepsin K and Matrix Metalloprotease Activities in Bone Tissue of the OXYS Rats During the Development of Osteoporosis, Biomed. Chem., 2009, vol. 3, no. 4, pp. 393–398.Google Scholar
- 28.WHO Assessment of Fracture Risk and its Application to Screening for Postmenopausal Osteoporosis: Report of a WHO Study Group in WHO Technical Report Series 843, WHO, Geneva, 1994.Google Scholar