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The Creation and Application Outlook of Calcium Phosphate and Magnesium Phosphate Bone Cements with Antimicrobial Properties (Review)

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Inorganic Materials: Applied Research Aims and scope

Abstract

An overview of the results in the field of creating bone cements based on calcium and magnesium phosphates with antimicrobial properties intended to replace bone tissue defects is presented. It was noted that the modification of cements based on calcium phosphates with magnesium made it possible to provide high strength, optimal setting time, absence of cytotoxicity, and increased matrix properties of the surface. The problems associated with the use of antibiotics in cement-based systems for their targeted prolonged delivery as bactericidal agents are discussed. Alternative approaches based on the doping of cements with elements exhibiting antimicrobial activity, which makes it possible to avoid the emergence of bactericidal agents, are considered.

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Funding

The work was supported by Russian Foundation for Basic Research, project no. 18-33-20170-mol-a-ved. Access to the electronic database of scientific publications was obtained within the framework of government task no. 075-00947-20-00.

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  1. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, 119334, Moscow, Russia

    M. A. Goldberg, V. V. Smirnov, P. A. Krokhicheva, S. M. Barinov & V. S. Komlev

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  1. M. A. Goldberg
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  2. V. V. Smirnov
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  3. P. A. Krokhicheva
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  4. S. M. Barinov
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Goldberg, M.A., Smirnov, V.V., Krokhicheva, P.A. et al. The Creation and Application Outlook of Calcium Phosphate and Magnesium Phosphate Bone Cements with Antimicrobial Properties (Review). Inorg. Mater. Appl. Res. 12, 195–203 (2021). https://doi.org/10.1134/S2075113321010093

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