Effect of Intermediate Ion Cleaning of the Titanium Target on the Structure of Bioresorbable PLLA Scaffolds under Coating Deposition by DC Reactive Magnetron Sputtering

Abstract

The effect of intermediate ion cleaning of the Ti target on the structure and properties of the polymer fiber scaffold made by electrospinning from poly-L-lactic acid (PLLA) was investigated during deposition of Ti-N-containing coatings by DC reactive magnetron sputtering of the Ti target in a nitrogen atmosphere. SEM investigation shows that the selected plasma treatment modes can modify fiber PLLA scaffolds without changing their morphological properties. Energy-dispersive spectroscopy showed that the Ti concentration on the surface of PLLA scaffolds is increased under intermediate ion cleaning of the target, although ion cleaning did not affect the Ti distribution across the scaffold cross section. Using optical goniometry, it was found that scaffold surface treatment allows changing the contact properties of the surface from hydrophobic to hydrophilic.

This is a preview of subscription content, log in to check access.

Fig. 1.
Fig. 2.

REFERENCES

  1. 1

    Long, Y., Biodegradable Polymer Blends and Composites from Renewable Resources, Chichester: Wiley, 2008.

    Google Scholar 

  2. 2

    Volkov, A.V., Synthetic biomaterials based on polymers of organic acids in tissue engineering, Kletochnaya Transplatologiya Tkanevaya Inzh., 2005, no. 2, pp. 43–45.

  3. 3

    Antonova, L.V., Matveeva, V.G., and Barbarash, L.S., Electrospinning and biodegradable small-diameter vascular grafts: problems and solutions (review), Kompl. Probl. Serdechno-Sosudistykh Zabol., 2015, no. 3, pp. 12–22.

  4. 4

    Bhardwaj, N. and Kundu, S.C., Electrospinning: a fascinating fiber fabrication technique, Biotechnol. Adv., 2010, vol. 28, no. 3, pp. 325–347.

    CAS  Article  Google Scholar 

  5. 5

    Gorelova, A.A., Murav’ev, A.N., Vinogradova, T.I., et al., Tissue-engineering technology in urethral reconstruction, Med. Al’yans, 2018, no. 3, pp. 75–82.

  6. 6

    Koerner, R.J., Butterworth, L.A., Mayer, I.V., Dasbach, R., and Busscher, H.J., Bacterial adhesion to titanium-oxynitride (TiNOX) coatings with different resistivities: a novel approach for the development of biomaterials, Biomaterials, 2002, vol. 23, no. 14, pp. 2835–2840.

    CAS  Article  Google Scholar 

  7. 7

    Musil, J., Baroch, P., Vlček, J., Nam, K.H., and Han, J.G., Reactive magnetron sputtering of thin films: present status and trends, Thin Solid Films, 2005, vol. 475, nos. 1–2, pp. 208–218.

  8. 8

    Cyster, L.A., Parker, K.G., Parker, T.L., and Grant, D.M., The effect of surface chemistry and nanotopography of titanium nitride (TiN) films on primary hippocampal neurons, Biomaterials, 2004, vol. 25, no. 1, pp. 97–107.

    CAS  Article  Google Scholar 

  9. 9

    Arnell, R.D. and Kelly, P.J., Recent advances in magnetron sputtering, Surf. Coat. Technol., 1999, vol. 112, no. 1–3, pp. 170–176.

  10. 10

    Martins, A., Pinho, E.D., Faria, S., Pashkuleva, I., Marques, A.P., Reis, R.L., and Neves, N.M., Surface modification of electrospun polycaprolactone nanofiber meshes by plasma treatment to enhance biological performance, Small, 2009, vol. 5, no. 10, pp. 1195–1206. https://doi.org/10.1002/smll.200801648

    CAS  Article  PubMed  Google Scholar 

  11. 11

    Bolbasov, E.N., Maryin, P.V., Stankevich, K.S., Goreninskii, S.I., Kudryavtseva, V.L., Mishanin, A.I., Golovkin, A.S., Malashicheva, A.B., Zhukov, Y.M., Anissimov, Y.G., and Tverdokhlebov, S.I., Nitrogen-doped titanium dioxide thin films formation on the surface of PLLA electrospun microfibers scaffold by reactive magnetron sputtering method, Plasma Chem. Plasma Process., 2019, vol. 39, no. 2, pp. 503–517.

    CAS  Article  Google Scholar 

  12. 12

    Bolbasov, E.N., Antonova, L.V., Stankevich, K.S., Ashrafov, A., Matveeva, V.G., Velikanova, E.A., Khodyrevskaya, Yu.I., Kudryavtseva, Yu.A., Anissimov, Y.G., Tverdokhlebov, S.I., and Barbarash, L.S., The use of magnetron sputtering for the deposition of thin titanium coatings on the surface of bioresorbable electrospun fibrous scaffolds for vascular tissue engineering: A pilot study, Appl. Surf. Sci., 2016, vol. 398, pp. 63–72.

    Article  Google Scholar 

  13. 13

    Tverdokhlebov, S.I., Bolbasov, E.N., Shesterikov, E.V., Antonova, L.V., Golovkin, A.S., Matveeva, V.G., and Anissimov, Y.G., Modification of polylactic acid surface using RF plasma discharge with sputter deposition of a hydroxyapatite target for increased biocompatibility, Appl. Surf. Sci., 2015, vol. 329, pp. 32–39.

    CAS  Article  Google Scholar 

  14. 14

    Arif, M. and Eisenmenger-Sittner, C., In situ assessment of target poisoning evolution in magnetron sputtering, Surf. Coat. Technol., 2017, vol. 324, pp. 345–352.

    CAS  Article  Google Scholar 

  15. 15

    Bolbasov, E.N., Maryin, P.V., Stankevich, K.S., Kozelskaya, A.I., Shesterikov, E.V., Khodyrevskaya, Y.I., and Tverdokhlebov, S.I., Surface modification of electrospun poly-(L-lactic) acid scaffolds by reactive magnetron sputtering, Colloids Surf., B, 2018, vol. 162, pp. 43–51.

    CAS  Article  Google Scholar 

  16. 16

    Barbarash, L.S., Bolbasov, E.N., Antonova, L.V., Matveeva, V.G., Velikanova, E.A., Shesterikov, E.V., and Tverdokhlebov, S.I., Surface modification of poly-ε-caprolactone electrospun fibrous scaffolds using plasma discharge with sputter deposition of a titanium target, Mater. Lett., 2016, vol. 171, pp. 87–90.

    CAS  Article  Google Scholar 

  17. 17

    Kelly, P.J. and Arnell, R.D., Magnetron sputtering: a review of recent developments and applications, Vacuum, 2000, vol. 56, no. 3, pp. 159–172.

    CAS  Article  Google Scholar 

  18. 18

    Townsend, P.D., Kelly, J.C., and Hartley, N.E.W., Ion Implantation, Sputtering and Their Applications, London: Academic, 1976.

    Google Scholar 

  19. 19

    Sputtering by Particle Bombardment I: Physical Sputtering of Single-Element Solids, Behrisch, R., Ed., Berlin: Springer, 1981.

    Google Scholar 

Download references

Funding

This work was supported by the Ministry of Science and Higher Education of the Russian Federation under the Federal Target Program, agreement no. 14.575.21.0140, unique identifier RFMEFI57517X0140.

Author information

Affiliations

Authors

Corresponding author

Correspondence to S. I. Tverdokhlebov.

Ethics declarations

The authors declare that they have no conflicts of interest.

Additional information

Translated by K. Lazarev

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Maryin, P.V., Ivanova, N.M., Shesterikov, E.V. et al. Effect of Intermediate Ion Cleaning of the Titanium Target on the Structure of Bioresorbable PLLA Scaffolds under Coating Deposition by DC Reactive Magnetron Sputtering. Inorg. Mater. Appl. Res. 11, 646–652 (2020). https://doi.org/10.1134/S2075113320030326

Download citation

Keywords:

  • poly-L-lactic acid
  • DC reactive magnetron sputtering
  • biocompatible coatings
  • ion cleaning