Abstract
A series of thiazine derivatives with the NO inhibiting effect was synthesized. These derivatives can be used in the treatment of gastrointestinal diseases, as well as antihypotensive (antishock) drugs. The potentially prolonged effect of these substances was studied by the adsorption of 2-N-benzoyl-2-amino-5,6-dihydro-4H-1,3-thiazine hydrobromide (I) on silica (nonporous Polysorb MP with specific surface area S = 330 m2/g and narrow-porous KSS-3 silica gel with S = 600 m2/g). The dehydroxylation of a silica surface significantly increased the adsorption of I. The adsorption kinetic curves of I showed a peak due to the rehydroxylation and deactivation of the silica surface in aqueous solutions. The adsorption rate in physiological solution of I was shown to decrease at a lower concentration of I on the surface of dehydroxylated silica and larger silica particles.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Proskuryakov, S.Ya., Konoplyannikov, A.G., Skvortsov, V.G., et al., Usp. Khim., 2005, vol. 74, no. 9, p. 939.
Salerno, L., Sorrenti, V., Di Giacomo, C., et al., Curr. Pharm. Des, 2002, vol. 8, no. 3, p. D. 177.
Granik, V.G. and Grigor’ev, N.B., Oksid azota (NO). Novyi put’ k poisku lekarstv (A New Way to Search for Drugs), Moscow: Vuzovskaya kniga, 2004.
Proskuryakov, S.Ya., Konoplyannikov, A.G., Ivannikov, A.I., et al., Usp. Sovr. Biol., 1999, vol. 119, no. 4, p. 380.
Janero, D.R., Free Radic. Biol. Med, 2000, vol. 28, no. 10, p. 1495.
Proskuryakov, S.Ya., Kucherenko, N.G., Trishkina, A.I., et al., Byull. Eksp. Biol. Med, 2004, vol. 138, no. 10, p. 446.
Hobbs, A.J., Higgs, A., and Moncada, S., Annu. Rev. Pharmacol. Toxicol, 1999, vol. 39, no. 1, p. 191.
Konoplyannikov, A.G., Proskuryakov, S.Ya., Konoplyannikova, O.A., et al., Radiats. Biol. Radioekol, 2007, vol. 47, no. 1, p. 5.
Proskuryakov, S.Ya., Kucherenko, N.G., Mandrugin, A.A., et al., Radiats. Biol. Radioekol, 2003, vol. 43, no. 1, p. 57.
Mandrugin, A.A. and Proskuryakov, S.Ya., RF Pat. 2338538.
Trofimova, T.P., Zefirova, O.N., Mandrugin, A.A., and Vestnik, Mosk., Un-Ta. Ser. 2. Khimiya, 2008, vol. 49, no. 5, p. 328.
Trofimova, T.P., Zefirova, O.N., Mandrugin, A.A, et al., Vestn. Mosk. Un-Ta, Ser. 2.
Mandrugin, A.A., Khokhlova, T.D., Trofimova, T.P., et al., III Int. Conf. on Colloid Chemistry and Physicochemical Mechanics, Moscow, 2008.
Khokhlova, T.D., Nikitin, Yu.S., and Detistova, A.L., Adsorpt. Sci. Technol., 1997, vol. 15, no. 5, p. 333.
Khokhlova, T.D. and Nikitin, Yu.S., Zh. Fiz. Khim., 1993, vol. 67, no. 10, p. 2098 [Russ. J. Phys. Chem. (Engl. Transl.), vol. 67, no. 10, p.].
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © T.D. Khokhlova, A.A. Mandrugin, T.P. Trofimova, V.M. Fedoseev, 2010, published in Fizikokhimiya Poverkhnosti i Zashchita Materialov, 2010, Vol. 46, No. 4, pp. 349–353.
Rights and permissions
About this article
Cite this article
Khokhlova, T.D., Mandrugin, A.A., Trofimova, T.P. et al. Adsorption of NO synthase inhibitor on dehydroxylated silica. Prot Met Phys Chem Surf 46, 427–429 (2010). https://doi.org/10.1134/S2070205110040064
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S2070205110040064