Advertisement

Polymer Science, Series D

, Volume 10, Issue 2, pp 189–193 | Cite as

Peculiarities of obtaining biocompatible films based on chitosan cross linked by genipin

  • N. R. Kil’deeva
  • M. A. Kasatkina
  • S. N. Mikhailov
Article

Abstract

The results of a study of gelation peculiarities in chitosan solutions in the presence of a cross-linking agent of natural origin and biocompatible properties of films obtained on the basis of the chitosan-solution–genipin gelling system are presented. The possibility of controlling the swelling degree of the films from 300 to 1800% are shown.

Keywords

chitosan chemical cross linking cross-linking reagent genipin gelation hydrogels films swelling degree 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J. M. Rosiak and F. Yoshii, “Hydrogels and their medical applications,” Nucl. Instrum. Methods Phys. Res. Sec. B 151 (1), 56–64 (1999).CrossRefGoogle Scholar
  2. 2.
    N. A. Peppas, P. Bures, W. Leobandung, and H. Ichikawa, “Hydrogels in pharmaceutical formulations,” Eur. J. Pharm. Biopharm. 50 (1), 27–46 (2000).CrossRefGoogle Scholar
  3. 3.
    N. A. Peppas, Y. Huang, M. Torres-Lugo, J. H. Ward, and J. Zhang, “Physicochemical foundations and structural design of hydrohydrogels in medicine and biology,” Annu. Rev. Biomed. Eng. 2 (1), 9–29 (2000).CrossRefGoogle Scholar
  4. 4.
    M. Rinaudo, “Chitin and chitosan: Properties and applications,” Prog. Polym. Sci. 31 (7), 603–632 (2006).CrossRefGoogle Scholar
  5. 5.
    Chitosan, Ed. by K. G. Skryabin, S. N. Mikhailov, and V. P. Varlamov (Tsentr “Bioinzheneriya” RAN, Moscow, 2013) [in Russian].Google Scholar
  6. 6.
    N. R. Kil’deeva and S. N. Mikhailov, “Hydrogels of chitosan modified with bifunctional crosslinking agents,” in Chitozan, Ed. by K. G. Skryabin, S.N. Mikhailov, and V.P. Varlamov (Tsentr “Bioinzheneriya” RAN, Moscow, 2013) [in Russian].Google Scholar
  7. 7.
    J. Berger, M. Reist, J. M. Mayer, O. Felt, N. A. Peppas, and R. Gurny, “Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications,” Eur. J. Pharm. Biopharm. 57 (1), 19–34 (2004).CrossRefGoogle Scholar
  8. 8.
    A. I. Azarova, P. A. Perminov, N. R. Kil’deeva, S. N. Mikhailov, and Vladimirov, L.V., “Gel formation in polymeric composites for modification of fibrous materials,” Fibre Chem. 43, 129–133 (2011).CrossRefGoogle Scholar
  9. 9.
    I. Panos, N. Acosta, and A. Heras, “New drug deliverysystems based on chitosan,” Curr. Drug Discov. Technol. 5 (4), 333–341 (2008).CrossRefGoogle Scholar
  10. 10.
    Y. Luo, K. R. Kirker, and G. D. Prestwich, “Crosslinked hyaluronic acid hydrogels films: New biomaterials for drug delivery,” J. Controlled Release 69 (1), 169–184 (2000).CrossRefGoogle Scholar
  11. 11.
    K. V. H. Harish Prashanth and R. N. Tharanathan, “Crosslinked chitosan—preparation and characterization,” Carbohydr. Res. 341 (1), 169–173 (2006).CrossRefGoogle Scholar
  12. 12.
    M. M. Beppu, R. S. Vieira, C. G. Aimoli, and C. C. Santana, “Crosslinking of chitosan membranes using glutaraldehyde: Effect on ion permeability and water absorption,” J. Membr. Sci. 301 (1), 126–130 (2007).CrossRefGoogle Scholar
  13. 13.
    N. R. Kildeeva, P. A. Perminov, L. V. Vladimirov, V. V. Novikov, and S. N. Mikhailov, “About mechanism of chitosan cross-linking with glutaraldehyde,” Russ. J. Bioorg. Chem. 35 (3), 360–369 (2009).CrossRefGoogle Scholar
  14. 14.
    M. F. Butler, Y.-F. Ng, and P. D. Pudney, “Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin,” J. Polym. Sci. Part A, Pol. Chem. 41 (24), 3941–3953 (2003).CrossRefGoogle Scholar
  15. 15.
    M. A. Pujana, L. Pérez-Álvarez, C. C. Iturbe, and I. Katime, “Biodegradable chitosan nanogels crosslinked with genipin,” Carbohydr. Res. 94 (2), 836–842 (2013).CrossRefGoogle Scholar
  16. 16.
    K. S. Huang, K. Lu, C. S. Yeh, et al., “Microfluidic controlling monodisperse microdroplet for 5-fluorouracil loaded genipin-gelatin microcapsules,” J. Controlled Release 137 (1), 15–19 (2009).CrossRefGoogle Scholar
  17. 17.
    H. G. Sundararaghavan, G. A. Monteiro, N. A. Lapin, et al., “Genipin-induced changes in collagen gels: Correlation of mechanical properties to fluorescence,” J. Biomed. Mater. Res. Part A 87 (2), 308–320 (2008).CrossRefGoogle Scholar
  18. 18.
    V. Chiono, E. Pulieri, G. Vozzi, et al., “Genipin-crosslinked chitosan/gelatin blends for biomedical applications,” J. Mater. Sci. Mater. Med. 19 (2), 889–898 (2008).CrossRefGoogle Scholar
  19. 19.
    A. O. Elzoghby, W. M. Samy, and N. A. Elgindy, “Novel spray-dried genipin-crosslinked casein nanoparticles for prolonged release of alfuzosin hydrochloride,” Pharm. Res. 30 (2), 512–522 (2013).CrossRefGoogle Scholar
  20. 20.
    H. Chen, W. Ouyang, B. Lawuyi, and S. Prakash, “Genipin cross-linked alginate-chitosan microcapsules: Membrane characterization and optimization of cross-linking reaction,” Biomacromolecules 7 (7), 2091–2098 (2006).CrossRefGoogle Scholar
  21. 21.
    J.-Y. Lai, Y.-T. Li, and T.-P. Wang, “In vitro response of retinal pigment epithelial cells exposed to chitosan materials prepared with different cross-linkers,” Int. J. Mol. Sci. 11 (12), 5256–5272 (2010).CrossRefGoogle Scholar
  22. 22.
    L. Felix, J. Hernandez, W. M. Arguelles-Monal, and F. M. Goycoolea, “Kinetics of gelation and thermal sensitivity of N-isobutyryl chitosan hydrogels,” Biomacromolecules 6 (5), 2408–2415 (2005).CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • N. R. Kil’deeva
    • 1
  • M. A. Kasatkina
    • 1
  • S. N. Mikhailov
    • 2
  1. 1.Moscow State University of Design and TechnologyMoscowRussia
  2. 2.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia

Personalised recommendations