Desorption Properties and Bactericidal and Fungicidal Activity of Nanostructured Coatings Based on Hexagonal Boron Nitride Saturated with Therapeutic Preparations


The study is aimed at creating nanostructured coatings based on hexagonal boron nitride with a high sorption capacity with respect to various therapeutic drugs and prolonged antibacterial effect due to gradual release into the physiological environment. The coatings were obtained via interaction of gaseous ammonia with a precursor of amorphous boron nanoparticles. The antibiotics gentamicin sulfate and ciprofloxacin and the antifungal drug amphotericin B were used as bactericides. The release kinetics of the antibiotics were assayed for different pH values. Antibacterial studies showed that all types of coatings are bactericidal to the antibiotic-resistant strain Escherichia coli K-261. Coatings saturated with amphotericin B showed antifungal activity against various ascomycete strains Neurospora crassa wild type wt-987 and nitrogen metabolism mutants nit-2 and nit-6.

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  1. 1

    Y. Liu, P. Ji, H. Lv, et al., Int. J. Biol. Macromol. 98, 550 (2017).

    CAS  Article  Google Scholar 

  2. 2

    H. R. Bakhsheshi-Rad, Z. Hadisi, E. Hamzah, et al., Mater. Lett. 207, 179 (2017).

    CAS  Article  Google Scholar 

  3. 3

    D. Ionita, D. Bajenaru-Georgescu, G. Totea, et al., Int. J. Pharm. 517, 296 (2017).

    CAS  Article  Google Scholar 

  4. 4

    W. Zhou, Z. Jia, P. Xiong, et al., Mater. Sci. Eng. C 90, 693 (2018).

    CAS  Article  Google Scholar 

  5. 5

    K. Glinel, P. Thebault, V. Humblot, et al., Acta Biomater. 8, 1670 (2012).

    CAS  Article  Google Scholar 

  6. 6

    M. Bhardwaj, B. R. Singh, D. K. Sinha, et al., Pharm. Anal. Acta 7, 523 (2016).

    Article  Google Scholar 

  7. 7

    A. Giedraitiene, A. Vitkauskiene, R. Naginiene, et al., Medicina (Kaunas) 47, 137 (2011).

    Article  Google Scholar 

  8. 8

    N. Woodford, A. P. Johnson, D. Morrison, et al., Clin. Microbiol. Rev. 8, 585 (1995).

    CAS  Article  Google Scholar 

  9. 9

    A. S. Konopatsky, D. V. Leybo, K. L. Firestein, et al., J. Catal. 368, 217 (2018).

    CAS  Article  Google Scholar 

  10. 10

    I. V. Sukhorukova, I. V. Zhitnyak, A. M. Kovalskii, et al., ACS Appl. Mater. Interfaces 7, 17217 (2015).

    CAS  Article  Google Scholar 

  11. 11

    M. Yamaguchi, D. M. Tang, C. Zhi, et al., Acta Mater. 60, 6213 (2012).

    CAS  Article  Google Scholar 

  12. 12

    K. L. Firestein, A. E. Shteinman, I. S. Golovin, et al., Mater. Sci. Eng. A 642, 104 (2015).

    CAS  Article  Google Scholar 

  13. 13

    M. Yamaguchi, J. Bernhardt, K. Firestein, et al., Acta Mater. 61, 7604 (2013).

    CAS  Article  Google Scholar 

  14. 14

    A. Pakdel, Y. Bo, D. Shtansky, et al., Surf. Innov. 1, 32 (2013).

    CAS  Article  Google Scholar 

  15. 15

    X. Chen, P. Wu, M. Rousseas, D. Okawa, et al., J. Am. Chem. Soc. 131, 890 (2009).

    CAS  Article  Google Scholar 

  16. 16

    L. Li, L. H. Li, S. Ramakrishnan, et al., J. Phys. Chem. C 116, 18224 (2012).

    CAS  Article  Google Scholar 

  17. 17

    G. Ciofani, S. Danti, G. G. Genchi, et al., Small 9, 1672 (2013).

    CAS  Article  Google Scholar 

  18. 18

    M. Emanet, O. Sen, and M. Culha, Nanomedicine 12, 797 (2017).

    CAS  Article  Google Scholar 

  19. 19

    H. Türkez, M. E. Arslan, E. Sönmez, et al., Cytotechnology 71, 351 (2019).

    CAS  Article  Google Scholar 

  20. 20

    N. Wang, H. Wang, C. Tang, et al., Int. J. Nanomed. 12, 5941 (2017).

    CAS  Article  Google Scholar 

  21. 21

    I. Ferah, The Effects of Boron Nitride and/or Hydroxyapatite Compounds on Experimentally Induced Osteomyelitis Following Open Femoral Fracture in Rats (Health Sciences Institute, Atatürk Univ., Erzurum, Turkey, 2015).

    Google Scholar 

  22. 22

    D. Lahiri, F. Rouzaud, T. Richard, et al., Acta Biomater. 6, 3524 (2010).

    CAS  Article  Google Scholar 

  23. 23

    X. Chen, P. Wu, M. Rousseas, et al., J. Am. Chem. Soc. 131, 890 (2009).

    CAS  Article  Google Scholar 

  24. 24

    M. Ikram, I. Jahan, A. Haider, et al., Appl. Nanosci. 10, 2339 (2020).

    CAS  Article  Google Scholar 

  25. 25

    J. C. O. Sardi, L. Scorzoni, T. Bernardi, et al., J. Med. Microbiol. 62, 10 (2013).

    CAS  Article  Google Scholar 

  26. 26

    A. T. Matveev, K. L. Firestein, A. E. Steinman, et al., Nano Res. 8, 2063 (2015).

    CAS  Article  Google Scholar 

  27. 27

    V. Tiana, Sh. Tang, Ch.-D. Wang, et al., Colloids Surf., B 123, 403 (2014).

    CAS  Article  Google Scholar 

  28. 28

    I. V. Sukhorukova, A. N. Sheveyko, A. Manakhov, et al., Mater. Sci. Eng. C 90, 289 (2018).

    CAS  Article  Google Scholar 

  29. 29

    O. Fursova, V. Potapov, A. Brouchkov, et al., Probiotics Antimicrob. Prot. 4, 145 (2012).

    CAS  Article  Google Scholar 

  30. 30

    E. S. Permyakova, L. Y. Antipina, A. M. Kovalskii, et al., J. Phys. Chem. C 122, 26409 (2018).

    CAS  Article  Google Scholar 

  31. 31

    E. S. Permyakova, L. Yu. Antipina, P. V. Kiryukhantsev-Korneev, et al., Nanomaterials 9, 1658 (2019).

    CAS  Article  Google Scholar 

  32. 32

    A. Brouchkov, V. Melnikov, L. Kalenova, et al., in Psychrophiles: From Biodiversity to Biotechnology, Ed. by R. Margesin (Springer, Switzerland, 2017), p. 541.

    Google Scholar 

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The study was supported by the Russian Science Foundation (contract 20-19-00120), as well as by the Ministry of Education and Science of the Russian Federation (NUST MISIS Competitiveness Enhancement Program no. K2A-2018-038) for IR spectroscopy studies (K.Yu. Gudz).

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Gudz, K.Y., Permyakova, E.S., Matveev, A.T. et al. Desorption Properties and Bactericidal and Fungicidal Activity of Nanostructured Coatings Based on Hexagonal Boron Nitride Saturated with Therapeutic Preparations. Nanotechnol Russia 15, 445–450 (2020).

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