Acid-base and adsorption properties of the AlOOH 2D nanostructures as factors for regulating parameters of model biological solutions
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We have studied the acid-base, adsorption, and electrokinetic properties of 2D nanostructures—agglomerates of pseudoboehmite (AlOOH) nanosheets 2–5 nm in thickness—that were synthesized from electro-explosive Al/AlN nanopowder. By the example of adsorption of anionic dye eosin and cationic dye methylene blue, it is found that the synthesized nanostructures have pronounced anion-exchange properties. It is shown that agglomerates of AlOOH nanosheets exhibit properties of a weak base when they are added to the biological model solutions (cell-culture medium and sodium phosphate buffer) and deionized water; in this case, an increase in pH in the media takes place both due to the release of the OH groups and the ionexchange adsorption. The possible impact of the synthesized AlOOH 2D nanostructures on the suppression of tumor-cell proliferation is considered via changes in the parameters (acidity and ionic composition) of their microenvironment.
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- 3.V. A. Oleinikov, A. V. Sukhanova, and I. R. Nabiev, “Fluorescent semiconductor nanocrystals in biology and medicine,” Ross. Nanotekhnol. 2 (1–2), 160–173 (2007).Google Scholar
- 6.V. A. Chubenko, “Promising treatments for malignant neoplasms,” Prakt. Onkol. 8 (4), 228–234 (2007).Google Scholar
- 8.N. Puvvada, S. Rajput, B. N. P. Kumar, S. Sarkar, S. Konar, K. R. Brunt, R. R. Rao, A. Mazumdar, S. K. Das, R. Basu, P. B. Fisher, M. Mandal, and A. Pathak, “Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression,” Sci. Rep. 5, 11760 (2015).CrossRefGoogle Scholar
- 10.D. M. Prescott, H. C. Charles, J. M. Poulson, R. L. Page, D. E. Thrall, Z. Vujaskovic, and M. W. Dewhirst, “The relationship between intracellular and extracellular pH in spontaneous canine tumors,” Clin. Cancer Res. 6, 2501–2505 (2000).Google Scholar
- 13.Physical and Chemical Aspects of Adsorbents and Catalysts, Ed. by B. G. Linsen (Academic, London, 1970; Mir, Moscow, 1973).Google Scholar
- 15.L. K. Gerunova, “Method of aluminium determination in biological objects,” RF Patent No. 2265842, Byull. Izobret. No. 34 (2005).Google Scholar
- 16.The Theory and Practice of pH Metric Definition of Acid-Base Properties of the Solid Surface, The School-Book, Ed. by K. V. Ikonnikova, L. F. Ikonnikova, T. S. Minakova, and Yu. S. Sarkisov (Tomsk. Politekh. Univ., Tomsk, 2011) [in Russian].Google Scholar
- 17.The Fluorides and Oxides of Alkaline Earth Metals and Magnesium. The Surface Properties, Ed. by T. S. Minakova and I. A. Ekimova (Tomsk. Gos. Univ., Tomsk, 2014) [in Russian].Google Scholar
- 18.G. G. Savel’ev, T. A. Yurmazova, A. I. Galanov, S. V. Sizov, N. B. Danilenko, M. I. Lerner, F. Teper, and L. Kaledin, “Adsorption capacity of nanosized fiber aluminium oxide,” Izv. Tomsk. Politekh. Univ. 307, 102–107 (2004).Google Scholar
- 21.C. Amphlett, Inorganic Ion Exchangers (Elsevier, Amsterdam, 1964; Mir, Moscow, 1966).Google Scholar