Nanotechnologies in Russia

, Volume 9, Issue 3–4, pp 126–135 | Cite as

Mesoporous silica particles as nanocontainers for phthalocyanine photosensitizers: estimation of efficiency in in vivo experiments

  • O. V. Dement’eva
  • M. A. Filippenko
  • M. M. Vinogradova
  • V. A. Ogarev
  • G. A. Meerovich
  • S. Sh. Karshieva
  • M. S. Belov
  • E. A. Luk’yanets
  • V. M. Rudoy
Article

Abstract

The template synthesis of mesoporous silica nanoparticles with predetermined size and porous structure is carried out. Water-soluble photosensitizer Photosens is used to study the possibility of applying such particles as containers for photosensitizers of a phthalocyanine series. In vivo experiments have shown that the application of such nanocontainers for the delivery of Photosens to a tumor makes it possible to improve the efficiency of fluorescence diagnostics and the photodynamic therapy of cancer.

Keywords

Phthalocyanine Mesoporous Silica Silica Nanoparticles Photo Sensitizer MESOPOROUS Silica Particle 

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • O. V. Dement’eva
    • 1
  • M. A. Filippenko
    • 1
  • M. M. Vinogradova
    • 1
    • 2
  • V. A. Ogarev
    • 1
  • G. A. Meerovich
    • 3
  • S. Sh. Karshieva
    • 4
  • M. S. Belov
    • 5
  • E. A. Luk’yanets
    • 6
  • V. M. Rudoy
    • 1
  1. 1.Frumkin Institute of Physical Chemistry and ElectrochemistryRussian Academy of SciencesMoscowRussia
  2. 2.Higher Chemical College of the Russian Academy of SciencesMendeleev Russian University of Chemical TechnologyMoscowRussia
  3. 3.Prokhorov Institute of General PhysicsRussian Academy of SciencesMoscowRussia
  4. 4.Blokhin Russian Cancer Research CenterRussian Academy of Medical SciencesMoscowRussia
  5. 5.Faculty of PhysicsMoscow State UniversityMoscowRussia
  6. 6.State Scientific Center “Research Institute of Organic Intermediates and Dyes,”MoscowRussia

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