Russian Journal of Physical Chemistry B

, Volume 12, Issue 1, pp 135–141 | Cite as

Supramolecular Conformational Effect in Complexations of Pectin and Chitosan Polysaccharides with Some Cephalosporin and Aminoglycoside Antibiotics

  • A. S. Shurshina
  • A. R. Galina
  • V. V. Chernova
  • L. G. Kuzina
  • E. I. Kulish
Chemical Physics of Biological Processes

Abstract

The reactions of the polysaccharides pectin (Pc) and chitosan (CTS) with antibiotics of cephalosporin and aminoglycoside series were studied. The complexation between the drugs and polymers was found to occur via hydrogen bonding. Dilution of the chitosan polycation increased the probability of occurrence of the negative ions of the cephalosporin antibiotic near the chain and lowered the probability of occurrence of the positive ions of aminoglycoside antibiotics, which affected the amount of adducts. When the pectin polyanion was diluted, the opposite situation was observed.

Keywords

polysaccharides conformation polyelectrolytes complexation 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • A. S. Shurshina
    • 1
  • A. R. Galina
    • 1
  • V. V. Chernova
    • 1
  • L. G. Kuzina
    • 1
  • E. I. Kulish
    • 1
  1. 1.Bashkir State UniversityUfaRussia

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