Russian Journal of Physical Chemistry B

, Volume 12, Issue 1, pp 46–52 | Cite as

Kinetics of the aza-Michael Reaction at Room Temperature

  • E. V. Koverzanova
  • I. I. Levina
  • A. A. Gridnev
Kinetics and Mechanism of Chemical Reactions. Catalysis


The rates of the aza-Michael reaction at room temperature were measured for some amines and alkenes. When the reaction mixture was diluted with methanol, the reaction was accelerated. The acceleration with methanol was especially strong for acrylonitrile. In the latter case, the reaction rate constant can increase by almost three decimal orders. The bulky substituent in the alpha position of methacrylates had little effect on the reaction rate, while the bulky substituent in the ester group significantly slowed the aza-Michael reaction.


aza-Michael reaction amine alkene reaction rate transition state catalysis methanol 


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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • E. V. Koverzanova
    • 1
  • I. I. Levina
    • 2
  • A. A. Gridnev
    • 1
  1. 1.Semenov Institute of Chemical PhysicsRussian Academy of SciencesMoscowRussia
  2. 2.Emanuel Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia

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