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SCF micronization of poly-3-hydroxybutyrate using supercritical antisolvent

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Abstract

Micronization of poly-3-hydroxybutyrate (PHB) by the supercritical fluid antisolvent precipitation (SAS) technique using supercritical carbon dioxide as an antisolvent was studied experimentally. The possibility of preparing particles of varying morphology (including hollow spheres) and specified size from 100 nm to 20 μm was demonstrated. The influence of different mechanisms of solid phase formation during SAS micronization on the size and morphology of PHB microparticles under different experimental conditions was considered.

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References

  1. S. Nadkar and C. Lokhande, Pharma Times 42, 17 (2010).

    Google Scholar 

  2. D. Chopra, M. Gulati, V. Saluja, P. Pathak, and P. Bansal, Recent Patents CNS Drug Discovery, No. 3, 216 (2008).

    Google Scholar 

  3. N. V. Majeti and R. Kumar, J. Pharm. Pharmaceut. Sci. 2, 234 (2000).

    Google Scholar 

  4. A. Shariati and C. J. Peters, Curr. Opin. Solid State Mater. Sci., No. 7, 371 (2003).

    Google Scholar 

  5. M. J. Cocero, A. Martin, F. Mattea, and S. Varona, Supercrit. Fluids, No. 47, 546 (2009).

    Google Scholar 

  6. M. Sokolsky-Papkov, K. Agashi, A. Olaye, K. Shakesheff, and A. J. Domb, Adv. Drug. Delivery Rev., No. 59, 187 (2007).

    Google Scholar 

  7. J. Bleich, B. W. Mueller, and W. Wassmus, Int. J. Pharm., No. 97, 111 (1993).

    Google Scholar 

  8. M. Sousa Costaa, A. R. C. Duarteb, M. M. Cardosoa, and C. M. M. Duarteb, Int. J. Pharmaceut., No. 328, 72 (2007).

    Google Scholar 

  9. E. Franceschi, A. M. de Cesaro, M. Feiten, S. R. S. Ferreira, C. Darivac, M. H. Kunita, A. F. Rubira, E. C. Muniz, M. L. Corazza, and J. V. Oliveira, J. Supercrit. Fluids, No. 47, 259 (2008).

    Google Scholar 

  10. E. Reverchon and I. Marcoa, Chem. Eng. J., No. 169, 358 (2011).

    Google Scholar 

  11. I. De Marco and E. Reverchon, J. Supercrit. Fluids, No. 58, 295 (2011).

    Google Scholar 

  12. I. De Marco and E. Torino, J. Supercrit. Fluids, No. 43, 126 (2007).

    Google Scholar 

  13. A. Martin and M. J. Cocero, Adv. Drug. Delivery Rev., 2, No. 60, 339.

  14. V. L. Myshkina, E. A. Ivanov, D. A. Nikolaeva, T. K. Makhina, A. P. Bonartsev, E. V. Filatova, A. O. Ruzhitskii, and G. A. Bonartseva, Prikl. Biokhim. Mikrobiol. 46 (3), 315 (2010).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Laser and Information Technologies, Troitsk, Moscow oblast, Russia

    L. I. Krotova, A. V. Mironov & V. K. Popov

Authors
  1. L. I. Krotova
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  2. A. V. Mironov
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  3. V. K. Popov
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Original Russian Text © L.I. Krotova, A.V. Mironov, V.K. Popov, 2013, published in Sverkhkriticheskie Flyuidy: Teoriya i Praktika, 2013, Vol. 8, No. 1, pp. 36–45.

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Krotova, L.I., Mironov, A.V. & Popov, V.K. SCF micronization of poly-3-hydroxybutyrate using supercritical antisolvent. Russ. J. Phys. Chem. B 7, 932–937 (2013). https://doi.org/10.1134/S1990793113080058

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  • DOI: https://doi.org/10.1134/S1990793113080058

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