Abstract
The structure of multiplayer liposomes prepared from chloroform solutions of egg phosphatidylcholine and ICHPHAN-10-C-10 synthetic antioxidant at ICHPHAN-to-lipid mass ratios of 0, 2, 4, 5, 10, 15 and 20% was studied by small-angle X-ray scattering. ICHPHAN caused a decrease in the lipid membrane thickness and in the period of their stacking in liposomes. This effect was most pronounced at a ICHPHAN-to-lipid mass ratio in the dispersion of 5%. At higher ICHPHAN concentrations, a decline in the ordering of the membranes in the liposomes was observed, which is presumably explained by ICHPHAN microphase segregation in the lipid multilayer. EPR spin probe measurements showed no appreciable changes in the lipid membrane microviscosity in the presence of ICHPHAN. The results demonstrated the ability of ICHPHAN to incorporate into lipid membranes in considerable quantities. Liposomes containing ICHPHAN can be used for developing new effective drugs for treatment of neurodegenerative diseases.
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Original Russian Text © A.V. Krivandin, L.D. Fatkullina, O.V. Shatalova, A.N. Goloshchapov, E.B. Burlakova, 2013, published in Khimicheskaya Fizika, 2013, Vol. 32, No. 5, pp. 91–96.
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Krivandin, A.V., Fatkullina, L.D., Shatalova, O.V. et al. Small-angle X-ray scattering study of the incorporation of ICHPHAN antioxidant in liposomes. Russ. J. Phys. Chem. B 7, 338–342 (2013). https://doi.org/10.1134/S1990793113050072
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DOI: https://doi.org/10.1134/S1990793113050072