Kinetic model of the transfer process of technogenic contaminants through liposomal membranes

  • E. A. Saratovskikh
  • B. L. Psikha
  • R. I. Gvozdev
  • Yu. I. Skurlatov
Reactivity. Kinetics of Chemical Reactions. Catalysis
  • 27 Downloads

Abstract

The transfer process of ecotoxic agents through a membrane is studied by the example of pesticides widely used in agriculture (lontrel, zenkor, bazagran, roundup, kuzagard, and setoksidim) and of lontrel complexes with cobalt and copper. All the compounds examined penetrate through the phosphatidylcholine membranes of liposomes. The kinetics of this process is studied by monitoring the rate of fluorescence quenching of ε-adenosine triphosphoric acid inside liposomes. On the basis of data obtained, a mathematical model of the process is proposed and the constants of mass transfer are calculated.

Keywords

Electron Paramagnetic Resonance Roundup Penetration Rate German Democratic Republic Liposomal Membrane 

References

  1. 1.
    A. V. Yablokov, Toxic Condiment (Mysl’, Moscow, 1990) [in Russian].Google Scholar
  2. 2.
    E. A. Saratovskikh, N. B. Kozlova, V. G. Papin, and E. V. Shtamm, Prikl. Biokhim. Mikrobiol. 42(1), 44 (2006).Google Scholar
  3. 3.
    B. T. Bowman and W. W. Sans, J. Environ. Sci. Health 18(6), 667 (1983).CrossRefGoogle Scholar
  4. 4.
    H. Miyoshi, T. Nishioka, and T. Fujita, Bull. Chem. Soc. Jpn. 59, 1099 (1986).CrossRefGoogle Scholar
  5. 5.
    Liposomes in Biological Systems, Ed. by G. Gregoriadis and A. C. Allison (Wiley, Chichester, 1980; Meditsina, Moscow, 1983).Google Scholar
  6. 6.
    Y. Utsuvi, K. Kiyoshige, S. Shimbara, and A. Hamada, Environ. Toxicol. Water Quality 9(4), 333 (1994).CrossRefGoogle Scholar
  7. 7.
    E. A. Saratovskikh, T. A. Kondrat’eva, B. L. Psikha, et al., Izv. Akad. Nauk SSSR, Ser. Khim., No. 11, 2501 (1988).Google Scholar
  8. 8.
    E. A. Saratovskikh, M. V. Lichina, B. L. Psikha, and R. I. Gvozdev, Izv. Akad. Nauk SSSR, Ser. Khim., No. 9, 1984 (1989).Google Scholar
  9. 9.
    Z. G. Aliev, L. O. Atovmyan, E. A. Saratovskikh, et al., Izv. Akad. Nauk SSSR, Ser. Khim., No. 11, 2495 (1988).Google Scholar
  10. 10.
    E. A. Saratovskikh, Izv. Akad. Nauk SSSR, Ser. Khim., No. 10, 2327 (1989).Google Scholar
  11. 11.
    M. V. Genkin, B. P. Ulanov, O. E. Dotsenko, and R. M. Davydov, Zh. Fiz. Khim. 61(1), 220 (1987).Google Scholar
  12. 12.
    T. A. Kondrat’eva, R. I. Gvozdev, and L. V. Tat’yanenko, Khim. Geterotsikl. Soedin, No. 7, 987 (1983).Google Scholar
  13. 13.
    J. R. Barrio, J. A. Secrist, N. J. Leonard, and G. Weber, Biochemistry 19(19), 3499 (1972).Google Scholar
  14. 14.
    A. Kotyk and K. Janaček, Membrane Transport: An Interdisciplinary Approach (Plenum, New York, 1977; Mir, Moscow, 1980).Google Scholar
  15. 15.
    D. A. Frank-Kamenetskii, Diffusion and Heat Transfer in Chemical Kinetics (Nauka, Moscow, 1987) [in Russian].Google Scholar
  16. 16.
    V. N. Golubev, Usp. Khim. 62(7), 726 (1993).Google Scholar
  17. 17.
    A. Leo, in Pesticide Synthesis Through Rational Approaches, Ed. by P. S. Magee, G. K. Kohn, and J. J. Menn (American Chemical Society, Washington, DC, 1984), pp. 213–218.Google Scholar
  18. 18.
    W. M. Arold, U. Zimmerman, W. Pauli, et al., Biochim. Biophys. Acta 942(1), 83 (1988).CrossRefGoogle Scholar

Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • E. A. Saratovskikh
    • 1
  • B. L. Psikha
    • 1
  • R. I. Gvozdev
    • 1
  • Yu. I. Skurlatov
    • 2
  1. 1.Institute of Problems of Chemical PhysicsRussian Academy of SciencesChernogolovka, Moscow oblastRussia
  2. 2.Semenov Institute of Chemical PhysicsRussian Academy of SciencesMoscowRussia

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