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Anti-mullerian hormone receptor type II as a Potential Target for Antineoplastic Therapy

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Abstract—

The review considers properties of anti-Mullerian hormone receptor type II (also known as Mullerian inhibiting substance receptor type II, MISRII), a transmembrane sensor, exhibiting own serine/threonine protein kinase activity, triggering apoptosis of Mullerian duct cells in mammalian embryogenesis and providing formation of the male-type reproductive system. According to recent data, MISRII overexpression in the postnatal period has been found in cells of a number of ovarian, mammary gland, and prostate tumors, and anti-Mullerian hormone (AMH) has a proapoptotic effect on MISRII-positive tumor cells. This fact makes MISRII a potential target for targeted antineoplastic therapy. Treatment based on MISRII targeting seems to be a much more effective alternative to the traditional one and will significantly reduce the dose of pharmacological agent due to its targeted delivery to malignant cells. In addition, antibodies specific to MISRII may be used to diagnose the malignances. However, the mechanism of MISRII-AMH interaction is still poorly understood and this complicates development of new anticancer drugs. The review considers molecular structure and expression levels of MISRII in various tissues and cell lines, as well as current knowledge on mechanisms of AMH receptor binding and data on the possibility of using MISRII as a target for the action of AMH-based antineoplastic drugs or MISRII specific antibodies.

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REFERENCES

  1. Lee, M. M. and Donahoe, P. K., Endocr. Rev., 1993, vol. 14, pp. 152–164. https://doi.org/10.1210/edrv-14-2-152

    Article  CAS  PubMed  Google Scholar 

  2. Gukasova, N.V. and Severin, S.E., Vorp. Biol. Med. Farm. Khim., 2005, vol. 4, pp. 3–9.

    Google Scholar 

  3. Durlinger, A.L., Visser, J.A., and Themmen, A.P., Reprod., 2002, vol. 124, pp. 601–609. https://doi.org/10.1530/rep.0.1240601

    Article  CAS  Google Scholar 

  4. Sriraman, V., Niu, E., Matias, J.R., Donahoe, P.K., MacLaughlin, D.T., Hardy, M.P., and Lee, M.M., J. Androl., 2001, vol. 22, pp.750–758. https://doi.org/10.1002/j.1939-4640.2001.tb02577.x

    Article  CAS  PubMed  Google Scholar 

  5. Kersual, N., Garambois, V., Chardès, T., Pouget, J.P., Salhi, I., Bascoul-Mollevi, C., Bibeau, F., Busson, M., Vié, H., Clémenceau, B., and Behrens, C.K., MAbs, 2014, vol. 6, no. 5, pp. 1314–1326. https://doi.org/10.4161/mabs.29316

    Article  PubMed  PubMed Central  Google Scholar 

  6. Donahoe, P.K., Clarke, T., Teixeira, J., Maheswaran, S., and MacLaughlin, D.T., Mol. Cell. Endocrinol., 2003, vol. 211, no. 1, pp. 37–42. https://doi.org/10.1016/j.mce.2003.09.009

    Article  CAS  PubMed  Google Scholar 

  7. MacLaughlin, D.T. and Donahoe, P.K., Future Oncol., 2010, vol. 6, no. 3, pp. 391–405.https://doi.org/10.2217/fon.09.172

  8. Orvis, G.D., Jamin, S. P., Kwan, K.M., Mishina, Y., Kaartinen, V.M., Huang, S., Roberts, A.B., Umans, L., Huylebroeck, D., Zwijsen, A., Wang, D., Martin, J.F., and Behringer, R.R., Biol. Reprod., 2008, vol. 78, pp. 994–1001. https://doi.org/10.1095/biolreprod.107.066605

    Article  CAS  PubMed  Google Scholar 

  9. Sedes, L., Leclerc, A., Moindjie, H., Cate, R.L., Picard, J.Y., di Clemente, N., and Jamin, S.P., PLoS One, 2013, vol. 8, no. 11, pp. 1–13. https://doi.org/10.1371/journal.pone.0081551

    Article  CAS  Google Scholar 

  10. Kim, J.H., MacLaughlin, D.T., and Donahoe, P.K., Obstet. Gynecol. Sci., 2014, vol. 57, no. 5, pp. 343–357. https://doi.org/10.5468/ogs.2014.57.5.343

    Article  PubMed  PubMed Central  Google Scholar 

  11. Gill, S.E., Zhang, Q., Keeney, G.L., Cliby, W.A., and Weroha, S.J., Oncotarget, 2017, vol. 8, no. 49, pp. 85214–85223. https://doi.org/10.18632/oncotarget.19620

    Article  PubMed  PubMed Central  Google Scholar 

  12. Rak, A.Ya., Trofimov, A.V., Pigareva, N.V., Simbirtsev, A.S., and Ischenko, A.M., Tsitokiny i Vospalenie, 2017, vol. 16, no. 3, pp. 58–61.

    Google Scholar 

  13. Teixeira, J., Maheswaran, S., and Donahoe, P.K., Endocr. Rev., 2001, vol. 22, no. 5, pp. 657–674. https://doi.org/10.1210/edrv.22.5.0445

    Article  CAS  PubMed  Google Scholar 

  14. Allard, S., Adin, P., Gouedard, L., di Clemente, N., Josso, N., Orgebin-Crist, M.C., Picard, J.Y., and Xavier, F., Development, 2000, vol. 127, pp. 3349–3360.

    CAS  PubMed  Google Scholar 

  15. Rak, A.Ya., Trofimov, A.V., Petrov, A.V., Simbirtsev, A.S., and Ishchenko, A.M., Tsitokiny i Vospalenie, 2016, vol. 15, no. 3, pp. 256–264.

    Google Scholar 

  16. Josso, N., Belville, C., Di Clemente, N., and Picard, J.Y., Hum. Reprod. Update, 2005, vol. 11, no. 4, pp. 351–356. https://doi.org/10.1093/humupd/dmi014

    Article  CAS  PubMed  Google Scholar 

  17. Segev, D.L., Hoshiya, Y., Hoshiya, M., Tran, T.T., Carey, J.L., Stephen, A.E., MacLaughlin, D.T., Donahoe, P.K., and Maheswaran, S., Proc. Natl. Acad. Sci. USA, 2002, vol. 99, pp. 239–244. https://doi.org/10.1073/pnas.221599298

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Massagué, J., Annu. Rev. Biochem., 1998, vol. 67, pp. 753–791. https://doi.org/10.1146/annurev.biochem.67.1.753

    Article  PubMed  Google Scholar 

  19. Massagué, J. and Weis-Garcia, F., Cancer Surv., 1996, vol. 27, pp. 41–64.

    PubMed  Google Scholar 

  20. Pankhurst, M.W., Leathart, B.L., Batchelor, N.J., and McLennan, I.S., Endocrinology, 2016, vol. 157, no. 4, pp. 1622–1629. https://doi.org/10.1210/en.2015-1834

    Article  CAS  PubMed  Google Scholar 

  21. Dijke, P.T., Curr. Med. Res. Opin., 2006, vol. 22, no. 1, S7–S11. https://doi.org/10.1185/030079906X80576

    Article  CAS  PubMed  Google Scholar 

  22. Clarke, T.R., Hoshiya, Y., Yi, S.E., Liu, X., Lyons, K.M., and Donahoe, P.K., Mol. Endocrinol., 2001, vol. 15, pp. 946–959. https://doi.org/10.1210/mend.15.6.0664

    Article  CAS  PubMed  Google Scholar 

  23. Onichtchouk, D., Gawantka, V., Dosch, R., Delius, H., Hirschfeld, K., Blumenstock, C., and Niehrs, C., Development, 1996, vol. 122, no. 10, pp. 3045–3053.

    CAS  PubMed  Google Scholar 

  24. Tang, S.J., Hoodless, P.A., Lu, Z., Breitman, M.L., McInnes, R.R., Wrana, J.L., and Buchwald, M., Development, 1998, vol. 125, no. 10, pp. 1877–1887.

    CAS  PubMed  Google Scholar 

  25. Massagué, J. and Wotton, D., EMBO J., 2000, vol. 19, no. 8, pp. 1745–1754. https://doi.org/10.1093/emboj/19.8.1745

    Article  PubMed  PubMed Central  Google Scholar 

  26. Gouedard, L., Chen, Y. G., Thevenet, L., Racine, C., Borie, S., Lamarre, I., Josso, N., Massagué, J., and di Clemente, N., J. Biol. Chem., 2000, vol. 275, pp. 27973–27978. https://doi.org/10.1074/jbc.M002704200

    Article  CAS  PubMed  Google Scholar 

  27. Visser, J.A., Olaso, R., Verhoef-Post, M., Kramer, P., Themmen, A.P., and Ingraham, H.A., Mol. Endocrinol., 2001, vol. 15, pp. 936–945. https://doi.org/10.1210/mend.15.6.0645

    Article  CAS  PubMed  Google Scholar 

  28. Jamin, S.P., Arango, N.A., Mishina, Y., Hanks, M.C., and Behringer, R.R., Nat. Genet., 2002, vol. 32, pp. 408–410. https://doi.org/10.1038/ng1003

    Article  CAS  PubMed  Google Scholar 

  29. Yong, Z., Fujino, A., MacLaughlin, D.T., Mangana-ro, T.F., Szotek, P.P., Arango, N.A., Teixeira, J., and Donahoe, P.K., Development, 2006, vol. 133, no. 12, pp. 2359–2369. https://doi.org/10.1242/dev.02383

    Article  CAS  Google Scholar 

  30. Imbeaud, S., Faure, E., Lamarre, I., Mattéi, M.G., Di Clemente, N., Tizard, R., Carré-Eusèbe1, D., Belville, C., Tragethon, L., Tonkin, C., Nelson, J., McAuliffe, M., Bidart, J.-M., Lababidi, A., Josso, N., Cate, R.L., and Picard, J.-Y., Nat. Genet., 1995, vol. 11, no. 4, pp. 382–388. https://doi.org/10.1038/ng1295-382

    Article  CAS  PubMed  Google Scholar 

  31. Visser, J.A., Mol. Cell. Endocrinol., 2003, vol. 211, no. 1, pp. 65–73. https://doi.org/10.1016/j.mce.2003.09.012

    Article  CAS  PubMed  Google Scholar 

  32. Nohe, A., Keating, E., Knaus, P., and Petersen, N.O., Cell. Signal., 2004, vol. 16, pp. 291–299. https://doi.org/10.1016/j.cellsig.2003.08.011

    Article  CAS  PubMed  Google Scholar 

  33. Papkoff, J., Rubinfeld, B., Schryver, B., and Polakis, P., Mol. Cell. Biol., 1996, vol. 16, no. 5, pp. 2128–2134.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R., EMBO J., 1997, vol. 16, no. 13, pp. 3797–3804.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Parr, B.A. and McMahon, A.P., Nature, 1998, vol. 395, no. 6703, p. 707.

    Article  CAS  PubMed  Google Scholar 

  36. Segev, D.L., Ha, T.U., Tran, T.T., Kenneally, M., Harkin, P., Jung, M., MacLaughlin, D.T., Donahoe, P.K., and Maheswaran, S., J. Biol. Chem., 2000, vol. 275, no. 37, pp. 28371–28379. https://doi.org/10.1074/jbc.M004554200

    Article  CAS  PubMed  Google Scholar 

  37. Barkett, M. and Gilmore, T. D., Oncogene, 1999, vol. 18, pp. 6910–6924.

    Article  CAS  PubMed  Google Scholar 

  38. Mishina, Y., Rey, R., Finegold, M.J., Matzuk, M.M., Josso, N., Cate, R.L., and Behringer, R.R., Genes Dev., 1996, vol. 10, pp. 2577–2587. https://doi.org/10.1101/gad.10.20.2577

    Article  CAS  PubMed  Google Scholar 

  39. Baarends, W.M., van Helmond, M.J., Post, M., van der Schoot, P.J., Hoogerbrugge, J.W., de Winter, J.P., Uilenbroek, J.T., Karels, B., Wilming, L.G., Meijers, J.H., Themmen, P.N., and Grootegoed, J.A., Development, 1994, vol. 120, pp. 189–197.

    CAS  PubMed  Google Scholar 

  40. di Clemente, N., Wilson, C., Faure, E., Boussin, L., Carmillo, P., Tizard, R., Picard, J.Y., Vigier, B., Josso, N., and Cate, R., Mol. Endocrinol., 1994, vol. 8, pp. 1006–1020. https://doi.org/10.1210/mend.8.8.7997230

    Article  CAS  PubMed  Google Scholar 

  41. Shiraishi, E., Yoshinaga, N., Miura, T., Yokoi, H., Wakamatsu, Y., Abe, S., and Kitano, T., Endocrinology, 2007, vol. 149, no. 4, pp. 1813–1819. https://doi.org/10.1210/en.2007-1535

    Article  CAS  PubMed  Google Scholar 

  42. Josso, N., Racine, C., di Clemente, N., Rey, R., and Xavier, F., Mol. Cell. Endocrinol., 1998, vol. 145, pp. 3–7.

    Article  PubMed  Google Scholar 

  43. Pundir, S., Martin, M.J., and O’Donovan, C., Methods Mol. Biol., 2017, vol. 1558, pp. 41–55. https://doi.org/10.1007/978-1-4939-6783-4_2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Hirschhorn, T., di Clemente, N., Amsalem, A.R., Pepinsky, R.B., Picard, J.Y., Smorodinsky, N.I., Cate, R.L., and Ehrlich, M., J. Cell. Sci., 2015, vol. 128, no. 7, pp. 1352–1364. https://doi.org/10.1242/jcs.160143

    Article  CAS  PubMed  Google Scholar 

  45. Attisano, L. and Wrana, J. L., Cytokine Growth F. R., 1996, vol. 7, no. 4, pp. 327–339. https://doi.org/10.1126/science.1071809

    Article  CAS  Google Scholar 

  46. Wrana, J.L., Attisano, L., Wieser, R., Ventura, F., and Massagué, J., Nature, 1994, vol. 370, no. 6488, pp. 341–347. https://doi.org/10.1038/370341a0

    Article  CAS  PubMed  Google Scholar 

  47. Baker, J.C. and Harland, R.M., Curr. Opin. Genet. Dev., 1997, vol. 7, no. 4, pp. 467–473. https://doi.org/10.1016/S0959-437X(97)80072-X

    Article  CAS  PubMed  Google Scholar 

  48. Kingsley, D.M., Genes Dev., 1994, vol. 8, no. 2, pp. 133–146.

    Article  CAS  PubMed  Google Scholar 

  49. Ichijo, H., Franzén, P., Schulz, P., Saras, J., Toyoshima, H., Heldin, C.H., and Miyazono, K., Oncogene, 1993, vol. 8, no. 10, pp. 2879–2887.

    PubMed  Google Scholar 

  50. Hinck, A.P., FEBS Lett., 2012, vol. 586, pp. 1860–1870. https://doi.org/10.1016/j.febslet.2012.05.028

    Article  CAS  PubMed  Google Scholar 

  51. Allendorph, G.P., Vale, W.W., and Choe, S., Proc. Natl. Acad. Sci. USA, 2006, vol. 103, pp. 7643–7648. https://doi.org/10.1073/pnas.0602558103

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Salhi, I., Cambon-Roques, S., Lamarre, I., Laune, D., Molina, F., Pugniere, M., Pourquier, D., Gutowski, M., Picard, J.Y., Xavier, F., and Pèlegrin, A., Biochem. J., 2004, vol. 379, no. 3, pp. 785–793. https://doi.org/10.1042/BJ20031961

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Xu, D. and Zhang, Y., Proteins, 2012, vol. 80, pp. 1715–1735. https://doi.org/10.1002/prot.24065

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Waterhouse, A., Bertoni, M., Bienert, S., Studer, G., Tauriello, G., Gumienny, R., Heer, F.T., de Beer, T.A.P., Rempfer, C., Bordoli, L., Lepore, R., and Schwede, T., Nucleic Acids Res., 2018, vol. 46, no. W1, pp. W296–W303. https://doi.org/10.1093/nar/gky427

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Josso, N., Belville, C., and Picard, J.Y., The Endocrinologist, 2003, vol. 13, no. 3, pp. 247–251. https://doi.org/10.1097/01.ten.0000081689.21823.79

    Article  CAS  Google Scholar 

  56. Messika-Zeitoun, L., Goue’dard, L., Belville, C., Dutertre, M., Lins, L., Imbeaud, S., Hughes, I.A., Picard, J.Y., Josso, N., and di Clemente, N., J. Clin. Endocrinol. Metab., 2001, vol. 86, pp. 4390–4397. https://doi.org/10.1210/jcem.86.9.7839

    Article  CAS  PubMed  Google Scholar 

  57. Wang, P.Y., Koishi, K., McGeachie, A.B., Kimber, M., Maclaughlin, D.T., Donahoe, P.K., and McLennan, I.S., Proc. Natl. Acad. Sci. USA, 2005, vol. 102, pp. 16421–16425. https://doi.org/10.1073/pnas.0508304102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Cimino, I., Casoni, F., Liu, X., Messina, A., Parkash, J., Jamin, S.P., Catteau-Jonard, S., Collier, F., Baroncini, M., Dewailly, D., Pigny, P., Prescott, M., Campbell, R., Herbison, A.E., Prevot, V., and Giacobini, P., Nat. Commun., 2016, vol. 7, no. 10055, pp. 1–12. https://doi.org/10.1038/ncomms10055

    Article  CAS  Google Scholar 

  59. Masiakos, P.T., MacLaughlin, D.T., Maheswaran, S., Teixeira, J., Fuller, A.F., Shah, P.C., Kehas, D.J., Kenneally, M.K., Dombkowski, D.M., Ha, T.U., Preffer, F.I., and Donahoe, P.K., Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res., 1999, vol. 5, pp. 3488−3499.

    CAS  Google Scholar 

  60. Song, J.Y., Chen, K.Y., Kim, S.Y., Kim, M.R., Ryu, K.S., Cha, J.H., Kang, C.S., MacLaughlin, D.T., and Kim, J.H., Int. J. Oncol., 2009, vol. 34, pp. 1583–1591. https://doi.org/10.3892/ijo_00000288

    Article  CAS  PubMed  Google Scholar 

  61. Anttonen, M., Färkkilä, A., Tauriala, H., Kauppinen, M., Maclaughlin, D.T., Unkila-Kallio, L., Bützow, R., and Heikinheimo, M., Lab. Investig. J. Tech. Methods. Pathol., 2011, vol. 91, pp. 1605–1614. https://doi.org/10.1038/labinvest.2011.116

    Article  CAS  Google Scholar 

  62. Pepin, D., Sosulski, A., Zhang, L., Wang, D., Vathipadiekal, V., Hendren, K., Coletti, C.M., Yu, A., Castro, C.M., Birrer, M.J., Gao, G., and Donahoe, P.K., Proc. Natl. Acad. Sci. USA, 2015, no. 112, pp. E4418–E4427. https://doi.org/10.1073/pnas.1510604112

  63. Tsuji, M., Shima, H., Yonemura, C.Y., Brody, J., Donahoe, P.K., and Cunha, G.R., Endocrinology, 1992, vol. 131, pp. 1481–1488. https://doi.org/10.1210/endo.131.3.1505479

    Article  CAS  PubMed  Google Scholar 

  64. Teixeira, J. and Donahoe, P.K., J. Androl., 1996, vol. 17, pp. 336–341. https://doi.org/10.1002/j.1939-4640.1996.tb01798.x

    Article  CAS  PubMed  Google Scholar 

  65. di Clemente, N. and Belville, C., Best Pract. Res. Clin. Endocrinol. Metab., 2006, vol. 20, pp. 599–610. https://doi.org/10.1016/j.beem.2006.09.004

    Article  CAS  PubMed  Google Scholar 

  66. Wu, X., Arumugam, R., Baker, S.P., and Lee, M.M., Endocrinology, 2005, vol. 146, pp. 589–595. https://doi.org/10.1210/en.2004-0646

    Article  CAS  PubMed  Google Scholar 

  67. Visser, J.A., de Jong, F.H., Laven, J.S., and Themmen, A.P., Reproduction, 2006, vol. 131, no. 1, pp. 1–9. https://doi.org/10.1530/rep.1.00529

    Article  CAS  PubMed  Google Scholar 

  68. Grøndahl, M.L., Nielsen, M.E., Dal Canto, M.B., Fadini, R., Rasmussen, I.A., Westergaard, L.G., Kristensen, S.G., and Yding Andersen, C., Reprod. Biomed. Online, 2011, vol. 22, no. 4, pp. 389–398. https://doi.org/10.1016/j.rbmo.2010.12.005

    Article  CAS  PubMed  Google Scholar 

  69. Pierre, A., Estienne, A., Racine, C., Picard, J.Y., Fanchin, R., Lahoz, B., Alabart, J.L., Folch, J., Jarrier, P., Fabre, S., and Monniaux, D., J. Clin. Endocrinol. Metab., 2016, vol. 101, no. 6, pp. 2602–2611. https://doi.org/10.1210/jc.2015-4066

    Article  CAS  PubMed  Google Scholar 

  70. Urmancheeva, A.F. and Meshkova, I.E., Prakticheskaya Onkologiya, 2000, vol. 4, pp. 7–13.

    Google Scholar 

  71. Siegel, R.L., Miller, K.D., and Jemal, A., CA Cancer J. Clin., 2016, vol. 66, pp. 7–30. https://doi.org/10.3322/caac.21332

    Article  PubMed  Google Scholar 

  72. Barnholtz-Sloan, J.S., Schwartz, A.G., Qureshi, F., Jacques, S., Malone, J., and Munkarah, A.R., Am. J. Obstet. Gynecol., 2003, vol. 189, pp. 1120–1127. https://doi.org/10.1067/S0002-9378(03)00579-9

    Article  PubMed  Google Scholar 

  73. Sato, S. and Itamochi, H., Oncotargets Ther., 2016, vol. 9, pp. 1181–1188. https://doi.org/10.2147/OTT.S98242

    Article  CAS  Google Scholar 

  74. Al Wadi, K. and Ghatage, P., Expert Opin. Pharmacother., 2016, vol. 17, pp. 853–860. https://doi.org/10.1517/14656566.2016.1161027

    Article  CAS  PubMed  Google Scholar 

  75. Estupina, P., Fontayne, A., Barret, J.M., Kersual, N., Dubreuil, O., Le Blay, M., Pichard, A., Jarlier M., Pugnière, M., Chauvin, M., Chardès, T., Pouget, J.P., Deshayes, E., Rossignol, A., Abache, T., de Romeuf, C., Terrier, A., Verhaeghe, L., Gaucher, C., Prost, J.F., Pèlegrin, A., and Navarro-Teulon, I. Oncotarget, 2017, vol. 8, pp. 37061–37079. https://doi.org/10.18632/oncotarget.15715

    Article  PubMed  PubMed Central  Google Scholar 

  76. Rey, R., Sabourin, J.C., Venara, M., Long, W.Q., Jaubert, F., Zeller, W.P., Duvillard, P., Chemes, H., and Bidart, J.M., Hum. Pathol., 2000, vol. 31, pp. 1202–1208. https://doi.org/10.1053/hupa.2000.18498

    Article  CAS  PubMed  Google Scholar 

  77. Bakkum-Gamez, J.N., Aletti, G., Lewis, K.A., Keeney, G.L., Thomas, B.M., Navarro-Teulon, I., and Cliby, W.A., Gynecol. Oncol., 2008, vol. 108, pp. 141–148. https://doi.org/10.1016/j.ygyno.2007.09.010

    Article  CAS  PubMed  Google Scholar 

  78. Bougherara, H., Némati, F., Nicolas, A., Massonnet, G., Pugnière, M., Ngô, C., Le Frère-Belda, M.A., Leary, A., Alexandre, J., Meseure, D., and Barret, J.M., Oncotarget, 2017, vol. 8, no. 59, pp. 99950–99965. https://doi.org/10.18632/oncotarget.21556

    Article  PubMed  PubMed Central  Google Scholar 

  79. Kim, A., Ueda, Y., Naka, T., and Enomoto, T., J. Exp. Clin. Cancer Res., 2012, vol. 31, no. 1, pp. 14–21. https://doi.org/10.1186/1756-9966-31-14

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Scully, R.E., Am. J. Pathol., 1977, vol. 87, no. 3, pp. 686–720.

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Shen, W.H., Moore, C.C., Ikeda, Y., Parker, K.L., and Ingraham, H.A., Cell, 1994, vol. 77, no. 5, pp. 651–661.

    Article  PubMed  Google Scholar 

  82. Beck, T.N., Korobeynikov, V.A., Kudinov, A.E., Georgopoulos, R., Solanki, N.R., Andrews-Hoke, M., Kistner, T.M., Pépin, D., Donahoe, P.K., Nicolas, E., and Einarson, M.B., Cell. Rep., 2016, vol. 16, no. 3, pp. 657–671. https://doi.org/10.1016/j.celrep.2016.06.043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Cate, R.L., Donahoe, P.K., and MacLaughlin, D.T., in Peptide Growth Factors and Their Receptors II, Sporn, M.B. and Roberts A.B., Eds., New York: Springer, 1990, pp. 179–210.

    Google Scholar 

  84. Di Clemente, N., Jamin, S.P., Lugovskoy, A., Carmillo, P., Ehrenfels, C., Picard, J.Y., Whitty, A., Josso, N., Pepinsky, R.B., and Cate, R.L., Mol. Endocrinol., 2010, vol. 24, no. 11, pp. 2193–2206. https://doi.org/10.1210/me.2010-0273

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Rak, A.Ya., Trofimov, A.V., Pigareva, N.V., Simbirtsev, A.S., and Ischenko, A.M., Cell Tissue Biol., 2018, vol. 12, no. 6, pp. 460–467. https://doi.org/10.1134/S1990519X18060093

    Article  Google Scholar 

  86. Rak, A.Ya., Trofimov, A.V., Protasov, E.A., Rodin, S.V., Zhakhov, A.V., Zabrodskaya, Ya.A., and Ischenko, A.M., Applied Biochem. Microbiol., 2019, vol. 55, no. 1, pp. 1–9. https://doi.org/10.1134/S0003683819010149

    Article  Google Scholar 

  87. Marca, A.L. and Volpe, A., Hum. Reprod. Update, 2007, vol.13, no. 3, pp. 265–273. https://doi.org/10.1093/humupd/dml060

    Article  PubMed  Google Scholar 

  88. Santibañez, J.F., Quintanilla, M., and Bernabeu, C., Clin. Sci. (Lond.), 2011, vol. 121, no. 6, pp. 233–251. https://doi.org/10.1042/CS20110086

    Article  CAS  Google Scholar 

  89. Josso, N., Rey, R., and Picard, J.Y., Int. J. Endocrinol., 2013, vol. 2013, pp. 1–12. https://doi.org/10.1155/2013/674105

    Article  CAS  Google Scholar 

  90. Kikuchi, K. and Hamaguchi, S., Dev. Dyn., 2013, vol. 242, no. 4, pp. 339–353. https://doi.org/10.1002/dvdy.23927

    Article  CAS  PubMed  Google Scholar 

  91. Wrana, J.L., Attisano, L., Cárcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X.F., and Massagué, J., Cell, 1992, vol. 71, no. 6, pp. 1003–1014. https://doi.org/10.1016/0092-8674(92)90395-S

    Article  CAS  PubMed  Google Scholar 

  92. Lorenzo, H.K., Teixeira, J., Pahlavan, N., Laurich, V.M., Donahoe, P.K., and MacLaughlin, D.T., J. Chromatogr. B, 2002, vol. 766, no. 1, pp. 89–98. https://doi.org/10.1016/S0378-4347(01)00436-4

    Article  CAS  Google Scholar 

  93. Papakostas, T.D., Pieretti-Vanmarcke, R., Nicolaou, F., Thanos, A., Trichonas, G., Koufomichali, X., Anago, K., Donahoe, P.K., Teixeira, J., Maclaughlin, D.T., and Vawas, D., Protein Express. Purif., 2010, vol. 70, no. 1, pp. 32–38. https://doi.org/10.1016/j.pep.2009.09.004

    Article  CAS  Google Scholar 

  94. Jung, Y.S., Kim, H.J., Seo, S.K., Choi, Y.S., Nam, E.J., Kim, S.W., Han, H.D., Kim, J.W., and Kim, Y.T., Yonsei Med. J., 2016, vol. 57, no. 1, pp. 33–40. https://doi.org/10.3349/ymj.2016.57.1.33

    Article  CAS  PubMed  Google Scholar 

  95. Barbie, T.U., Barbie, D.A., MacLaughlin, D.T., Maheswaran, S., and Donahoe, P.K., Proc. Natl. Acad. Sci. USA, 2003, vol. 100, no. 26, pp. 15601–15606. https://doi.org/10.1073/pnas.2636900100

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  96. di Clemente, N., Josso, N., Gouédard, L., and Belville, C., Mol. Cell. Endocrinol., 2003, vol. 211, no. 1, pp. 9–14. https://doi.org/10.1016/j.mce.2003.09.005

    Article  CAS  PubMed  Google Scholar 

  97. Bennett, B.L., Sasaki, D.T., Murray, B.W., O’Leary, E.C., Sakata, S.T., Xu W., Leisten, J.C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S.S., Manning, A.M., and Anderson, D.W., Proc. Natl. Acad. Sci. USA, 2001, vol. 98, pp. 13681–13686. https://doi.org/10.1073/pnas.251194298

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Renlund, N., Pieretti-Vanmarcke, R., O’Neill, F.H., Zhang, L., Donahoe, P.K., and Teixeira, J., Endocrinology, 2007, vol. 149, no. 1, pp. 108–115. https://doi.org/10.1210/en.2007-0529

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Deshayes, E., Ladjohounlou, R., Le Fur, P., Pichard, A., Lozza, C., Boudousq, V., Sevestre, S., Jarlier, M., Kashani, R., Koch, J., and Sosabowski, J., J. Nucl. Med., 2018, vol. 59, no. 8, pp. 1234–1242. https://doi.org/10.2967/jnumed.118.208611

    Article  CAS  PubMed  Google Scholar 

  100. Verheijen, R.H., Massuger, L.F., Benigno, B.B., Epenetos, A.A., Lopes, A., Soper, J.T., Markowska, J., Vyzula, R., Jobling, T., Stamp, G., and Spiegel, G., J. Clin. Oncol., 2006, vol. 24, pp. 571–578. https://doi.org/10.1200/JCO.2005.02.5973

    Article  CAS  PubMed  Google Scholar 

  101. Jacquet, A., Kersual, N., Garambois, V., Fontayne, A., Pujols, F., Fournier, N., Pugnière, M., Chavanieu, A., de Romeuf, C., Prost, J.F., Urbain, R., Pèlegrin, A., Gaucher, C., and Teulon-Navarro, I., Cancer Res., 2012, vol. 72, 2528. https://doi.org/10.1158/1538-7445

    Article  Google Scholar 

  102. Gharpure, K.M., Wu, S.Y., Li, C., Lopez-Berestein, G., and Sood, A.K., Clin. Cancer Res., 2015, vol. 21, no. 14, pp. 3121–3130. https://doi.org/10.1158/1078-0432.CCR-14-1189

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. State Research Institute for Highly Pure Biopreparations, ul. Pudozhskaya 7, 197110, Saint-Petersburg, Russia

    A. Ya. Rak, A. V. Trofimov & A. M. Ischenko

  2. Saint-Petersburg State University, Universitetskaya nab. 7/9, 199034, Saint-Petersburg, Russia

    A. Ya. Rak

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Rak, A.Y., Trofimov, A.V. & Ischenko, A.M. Anti-mullerian hormone receptor type II as a Potential Target for Antineoplastic Therapy. Biochem. Moscow Suppl. Ser. B 13, 202–213 (2019). https://doi.org/10.1134/S1990750819030053

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