Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection

  • O. A. Dukova
  • M. Yu. Kotlovsky
  • A. A. Pokrovsky
  • E. V. Suvorova
  • T. G. Shivrina
  • E. A. Krasnov
  • A. A. Efremov
Article

Abstarct

A method of identification and quantitative determination of baclofen in blood by HPLC with mass spectrometry detection has been developed. It is characterized by high sensitivity, specificity, linearity, accuracy, reproducibility, and a low detection for quantitative determination. The method has been used for diagnostics of acute baclofen poisoning in patients.

Keywords

baclofen poisoning diagnostics HPLC-MS/MS 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • O. A. Dukova
    • 1
    • 2
  • M. Yu. Kotlovsky
    • 3
  • A. A. Pokrovsky
    • 3
  • E. V. Suvorova
    • 2
  • T. G. Shivrina
    • 4
  • E. A. Krasnov
    • 5
  • A. A. Efremov
    • 1
  1. 1.Siberian Federal UniversityKrasnoyarskRussia
  2. 2.Krasnoyarsk Regional Bureau of Forensic Medical ExpertiseKrasnoyarskRussia
  3. 3.Central Research LaboratoryVoyno-Yasenetsky Krasnoyarsk Medical UniversityKrasnoyarskRussia
  4. 4.Karpovich Municipal Clinical Emergency Hospital no. 6KrasnoyarskRussia
  5. 5.Siberian Medical UniversityTomskRussia

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