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The role of innate immunity in induction of tolerance

  • M. S. Dolgikh
Article
  • 64 Downloads

Abstract

The review considers the role of innate immunity in mechanisms of transplant tolerance and rejection. Special attention is paid to analysis of the role of innate immunity cells (dendritic cells, NK, mast and other cells) in these processes, and also approaches to creation of tolerogenic dendritic cells for therapy of transplant rejection as well as tolerance development.

Keywords

tolerance transplantology innate immunity adaptive immunity innate immunity cells 

Abbreviations used

APC

antigen presenting cell

αBC

αB-Crystallin

BiP

binding immunoglobulin protein

CpG

DNA sites enriched with C and G

DAMP

danger-associated molecular patterns

DC

dendritic cells

iDC

immature DC

HMGB1

high-mobility group box 1 (a protein of high electrophoretic activity also known as amphoterin. Binding of a nuclear non-histone protein to the TLR4 receptor of innate immunity results in secretion of cytokines by activated macrophages and monocytes followed by subsequent inflammatory reaction)

HLA

human leukocyte antigens

HSP (HSP 10, HSP 27)

heat shock proteins

IFN

interferon

KC/CXCL 1

chemokine recruiting neutrophils and basophils

IL

interleukins

LPS

lipopolysaccharide

MCP6

mast cell protease-6

MDP

muramyl dipeptide

MHC

major histocompatibility complex

MIP-2/CXCL 2

macrophage inflammatory protein

MyD88

myeloid differentiation factor 88

NK

natural killers

NLRs

NOD-like receptors (NOD-nucleotide-oligomerizing domain) intracellular sensors of cell stress

PAMP

pathogen-associated molecular patterns

P1, P2X, P2Y

purinergic receptors

PMN

polymorphonuclear neutrophil

PRR

patterns recognizing receptors

RAG

recombinase activating gene

RAGE

receptor of advanced glycation end product

RAMP

resolution-associated molecular patterns

RLHs

RIG-like helicases (RIG-retinoic acid inducible gene)

TGF

transforming growth factor

TLR

toll-like receptors

TNF

tumor necrosis factors

Tregs

regulatory T-cells

Th1 and Th2

T-helpers of type 1 and type 2 polarization (balance of T-helper differentiation determines the immune response)

sTNF-R

soluble TNF-receptor

TRIF

TIR(Toll-IL-IR)-containing adapter-inducing interferon-β

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© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  1. 1.Shumakov Institute of Transplantology and Artificial OrgansMoscowRussia

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