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Hypoxic preconditioning modifies activity of pro- and antioxidant systems in the rat hippocampus

  • M. S. Kislin
  • S. A. Stroev
  • T. S. Gluschenko
  • E. I. Tyulkova
  • M. Pelto-Huikko
  • M. O. Samoilov
Article

Abstract

The effects of repetitive mild hypobaric hypoxic preconditioning on pro- and antioxidant systems in rat hippocampus have been studied. It was found that three-trial preconditioning by mild hypobaric hypoxia (360 mm Hg, 2 h) induced moderate oxidative stress immediately after the last preconditioning trial. In addition, it down regulated the levels of protein antioxidants (Trx-1, Trx-2, Cu,Zn-SOD) and also decreased several lipid peroxidation products 24 h after the preconditioning.

Keywords

preconditioning hypobaric hypoxia antioxidants lipid peroxidation hippocampus 

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • M. S. Kislin
    • 1
  • S. A. Stroev
    • 1
    • 2
  • T. S. Gluschenko
    • 1
  • E. I. Tyulkova
    • 1
  • M. Pelto-Huikko
    • 2
  • M. O. Samoilov
    • 1
  1. 1.Pavlov Institute of PhysiologyRussian Academy of SciencesSt.-PeterburgRussia
  2. 2.Tampere UniversityTampereFinland

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