The induction of Guerin’s carcinoma cytochrome P450 hydroxylase activity by retinoids



Using Guerin’s carcinoma as a model the interrelationship between the tumor growth process and supplementation of the body with vitamin A has been studied. The replenishment of vitamin A resources of vitamin-deficient tumor bearing animals modulated the Guerin’s carcinoma growth rate in a dose dependent manner (r = 0.83). The morphological parameters of tumor growth under conditions of supplementation with vitamin A (0–3000 IU) positively correlated with hydroxylase (r = 0.81) and demethylase (r = 0.49) activities of the Guerin’s carcinoma cytochrome P450 system. The increase in the tumor growth rate together with the induction of hydroxylase and demethylase activities of cytochrome P450 in the Guerin’s carcinoma microsomal fraction, observed either under conditions of retinyl acetate overdose supplementation, or selective liposomal form of all-trans-retinoic acid, suggests the stimulatory effect of retinoids on tumor growth.


retinoids cytochrome P450 Guerin’s carcinoma 


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  1. 1.
    Chambon, P., FASEB J., 1996, vol. 10, pp. 940–954.Google Scholar
  2. 2.
    Chawla, A., Repa, J.J., Evans, R.M., and Mangelsdorf, D.J., Science, 2001, vol. 294, pp. 1866–1870.CrossRefGoogle Scholar
  3. 3.
    Balmer, J.E. and Blomhoff, R., J. Lipid Res., 2002, vol. 43, pp. 1773–1808.CrossRefGoogle Scholar
  4. 4.
    Soprano, K.J. and Soprano, D.R., J. Nutr., 2002, vol. 132, pp. 3809S–3813S.Google Scholar
  5. 5.
    Tsimberidou, A., Tirado-Gomez, M., Andreeff, M., O’Brien, S., Kantarjian, H., Keating, M., Lopez-Berestein, G., and Estey, E., Leuk. Lymph., 2006, vol. 47, pp. 1062–1068.CrossRefGoogle Scholar
  6. 6.
    Gallicchio, L.K., Am. J. Clin. Nutr., 2008, vol. 76, pp. 372–389.Google Scholar
  7. 7.
    Crowe, D., Kim, R., and Chandraratna, R., Mol. Cancer Res., 2003, vol. 1, pp. 532–540.Google Scholar
  8. 8.
    Leo, M.A., and Lieber, C.S., Am. J. Clin. Nutr., 1999, vol. 69, pp. 1071–1085.Google Scholar
  9. 9.
    Oyama, T., Kagawa, N., Kunugita, N., Kitagawa, K., Ogawa, M., Yamaguchi, T., Suzuki, R., Kinaga, T., Yashima, Y., Ozaki, S., Isse, T., Kim, Y., Kim, H., and Kawamoto, T., Front. Biosci., 2004, vol. 9, pp. 1967–1976.CrossRefGoogle Scholar
  10. 10.
    Nebert, D.W. and Dalton, T.P., Nat. Rev., 2006, vol. 6, pp. 947–960.CrossRefGoogle Scholar
  11. 11.
    Koblyakov, V.A., Biochemistry (Moscow), 1998, vol. 63, pp. 1043–1058.Google Scholar
  12. 12.
    Murray, M., Sefton, R., Croft, K., and Butler, A., Br. J. Pharmacol., 2001, vol. 134, pp. 1487–1497.CrossRefGoogle Scholar
  13. 13.
    Marchenko, M.M., Shmarakov, I.A., and Pasailyuk, M.V., Vopr. Pitaniya, 2008, vol. 77, no. 6, pp. 4–8.Google Scholar
  14. 14.
    Sporn, M.B., Roberts, A.B., and Goodman, D.S., The Retinoids: Biology, Chemistry, and Medicine, New York: Raven Press, 1994.Google Scholar
  15. 15.
    Marchenko, M.M., Shmarakov, I.A., and Pasailyuk, M.V., Ukr. Biokhim. Zh., 2007, vol. 79, no. 4, pp. 127–135.Google Scholar
  16. 16.
    Donenko, F.D., and Moroz, L.V., Vestnik RAMS, 1995, no. 4, pp. 14–16.Google Scholar
  17. 17.
    Marchenko, M.M., Kopil’tchuk, G.P., Ketsa, O.V., and Shmarakov, I.A., Ukr. Biokhim. Zh., 2006, vol. 78, no. 4, pp. 66–72.Google Scholar
  18. 18.
    Budker, V.G., Vakhrusheva, T.E., Kiseleva, E.V., and Khristolyubova, N.B., Khim. Farm. Zh., 1987, no. 3, pp. 347–352.Google Scholar
  19. 19.
    Roos, T., Juger, F., Merk, F., and Bickers, D., Pharmacol. Rev., 1998, vol. 50, pp. 315–333.Google Scholar
  20. 20.
    Ross, C.A., J. Nutrition, 2003, vol. 133, pp. 291S–296S.Google Scholar
  21. 21.
    Albright, C., Salganik, R., and Dyke, T., J. Nutrition, 2004, vol. 134, pp. 1139–1144.Google Scholar
  22. 22.
    Bruno, R. and Njar, V., Bioorg. Med. Chem., 2007, vol. 15, pp. 5047–5060.CrossRefGoogle Scholar
  23. 23.
    Roy, B., Ogundigie, P., Fujimoto, N., and Ito, A., Jpn. J. Cancer Res., 1991, vol. 82, pp. 815–819.CrossRefGoogle Scholar
  24. 24.
    Peehl, D. and Feldman, D., Endocrine-Related Cancer, 2003, vol. 10, pp. 131–140.CrossRefGoogle Scholar

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© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Department of Biochemistry and BiotechnologyYuri Fed’kovich Chernivtsi National UniversityChernivtsiUkraine

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