The effect of various modes of surgical injury of rat buccal mucosa on the content of basic fibroblast growth factor and interleukins 1β and 6 in the dynamics of reparative processes



The content of basic fibroblast growth factor (bFGF) and also interleukins 1β and 6 (IL-1β and IL-6) has been investigated in rat buccal mucosa after its surgical injury by an erbium laser (Er:YAG laser) and a scalpel. The laser emission caused a sharp increase in the content of these regulators on the second day after treatment followed by decrease observed on the seventh day. These results may reflect synergistic effect of these peptide regulators in the wound defect. Changes in time-course of bFGF, IL-1β and IL-6 release in the wound formed by the laser beam compared with the wound induced by the cutting instrument may promote earlier appearance of the proliferation phase.


basic fibroblast growth factor interleukins Er:YAG laser wound oral mucosa 


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© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Moscow Medical Dental UniversityMoscowRussia
  2. 2.Institute of Biomedical ChemistryRussian Academy of Medical SciencesMoscowRussia

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