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The glutathione system. II. Other enzymes, thiol-disulfide metabolism, inflammation, and immunity, functions

  • V. I. Kulinsky
  • L. S. Kolesnichenko
Review

Abstract

The great importance of glutathione as a redox regulator and the reducing carrier has been recognized. There is clear necessity for subdivision of an independent mitochondrial glutathione subsystem. The data on specific features of glutathione metabolism in different organs are accumulated. There is convincing evidence for the involvement of the glutathione system into inflammation and immunity. Studies of the glutathione system are used in medicine for elucidation of pathogenesis of diseases and their diagnostics.

Key words

glutathione metabolism enzymes thiol-disulfide inflammation immunity functions 

Abbreviations used

ARE

antioxidant responsive element

ER

endoplasmic reticulum

GGT

gamma-glutamyl transferase

GR

glutathione reductase

Grx

glutaredoxin

LPO

lipid peroxidation

LT

leukotrienes

MCh

mitochondria

NF

κB-nuclear factor κ-B

Nrf2

NF erythroid 2p45-related factor 2

OS

oxidative stress

PK

protein kinase

ROS

reactive oxygen species

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© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  1. 1.Department of BiochemistryIrkutsk State Medical UniversityIrkutskRussia
  2. 2.Department of Bioinorganic and Bioorganic ChemistryIrkutsk State Medical UniversityIrkutskRussia

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