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The glutathione system. II. Other enzymes, thiol-disulfide metabolism, inflammation, and immunity, functions

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Abstract

The great importance of glutathione as a redox regulator and the reducing carrier has been recognized. There is clear necessity for subdivision of an independent mitochondrial glutathione subsystem. The data on specific features of glutathione metabolism in different organs are accumulated. There is convincing evidence for the involvement of the glutathione system into inflammation and immunity. Studies of the glutathione system are used in medicine for elucidation of pathogenesis of diseases and their diagnostics.

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Abbreviations

ARE:

antioxidant responsive element

ER:

endoplasmic reticulum

GGT:

gamma-glutamyl transferase

GR:

glutathione reductase

Grx:

glutaredoxin

LPO:

lipid peroxidation

LT:

leukotrienes

MCh:

mitochondria

NF:

κB-nuclear factor κ-B

Nrf2:

NF erythroid 2p45-related factor 2

OS:

oxidative stress

PK:

protein kinase

ROS:

reactive oxygen species

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Authors and Affiliations

  1. Department of Biochemistry, Irkutsk State Medical University, Irkutsk, Russia

    V. I. Kulinsky

  2. Department of Bioinorganic and Bioorganic Chemistry, Irkutsk State Medical University, Irkutsk, Russia

    L. S. Kolesnichenko

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  1. V. I. Kulinsky
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  2. L. S. Kolesnichenko
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Correspondence to V. I. Kulinsky.

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Original Russian Text © V.I. Kulinsky, L.S. Kolesnichenko, 2009, published in Biomeditsinskaya Khimiya.

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Kulinsky, V.I., Kolesnichenko, L.S. The glutathione system. II. Other enzymes, thiol-disulfide metabolism, inflammation, and immunity, functions. Biochem. Moscow Suppl. Ser. B 3, 211–220 (2009). https://doi.org/10.1134/S1990750809030019

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  • DOI: https://doi.org/10.1134/S1990750809030019

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