The glutathione system. II. Other enzymes, thiol-disulfide metabolism, inflammation, and immunity, functions

  • V. I. Kulinsky
  • L. S. Kolesnichenko


The great importance of glutathione as a redox regulator and the reducing carrier has been recognized. There is clear necessity for subdivision of an independent mitochondrial glutathione subsystem. The data on specific features of glutathione metabolism in different organs are accumulated. There is convincing evidence for the involvement of the glutathione system into inflammation and immunity. Studies of the glutathione system are used in medicine for elucidation of pathogenesis of diseases and their diagnostics.

Key words

glutathione metabolism enzymes thiol-disulfide inflammation immunity functions 

Abbreviations used


antioxidant responsive element


endoplasmic reticulum


gamma-glutamyl transferase


glutathione reductase




lipid peroxidation






κB-nuclear factor κ-B


NF erythroid 2p45-related factor 2


oxidative stress


protein kinase


reactive oxygen species


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© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  1. 1.Department of BiochemistryIrkutsk State Medical UniversityIrkutskRussia
  2. 2.Department of Bioinorganic and Bioorganic ChemistryIrkutsk State Medical UniversityIrkutskRussia

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