Advertisement

Assessment of some oxidative stress parameters in patients with bronchial asthma after selenium supplementation

  • J. G. Voicehovska
  • A. Shkesters
  • G. A. Orlikov
  • A. A. Silova
  • N. J. Rusakova
  • L. T. Larmane
  • J. G. Karpov
  • A. D. Ivanov
  • E. Maulinsh
Clinical Studies

Abstract

The goal of this study was to investigate the effect of selenium deficit replenishment in patients with bronchial asthma (BA) on manifestations of oxidative stress and conditions of the antioxidant system (AOS). The need of correction of selenium deficit in BA-patients is determined by increased requirements in antioxidants due to chronic inflammatory process responsible for pathogenesis of BA. Latvia as well as Eastern Finland, Byelorussia, some regions of Ukraine, North-Western Russia, and New Zealand belong to the endemic areas with marked selenium deficit in soils and foodstuff. Twenty patients (7 men and 13 women) with selenium deficit and verified diagnosis of BA have been examined. In addition to basic therapy all patients received organic selenium as SelenoPRECISE (PharmaNord) 200 μg daily for 16 weeks. This caused statistically significant increase of plasma selenium from 50.94 ± 7.58 to 63.59 ± 10.87 μg/l (p < 0.001), the increase of selenium-dependent glutathione peroxidase (from 38.64 ± 10.72 U/g Hb to 58.57 ± 14.64 U/g Hb, p = 0.01). Treatment of patients with selenium also normalized the parameters characterizing oxidative stress (chemiluminescence), significantly exceeded normal values before this treatment. The use of selenium in addition to basic therapy allows to abolish or reduce oxidative stress by correcting the antioxidant system.

Key words

bronchial asthma inflammation oxidative stress selenium 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Global Initiative for Asthma (GINA), Global Strategy for Asthma Management and Prevention, NIH Publication 02-3659 Issued January 1995 (updated 2002, 2003, 2004), At http://www.sinasthma.com
  2. 2.
    Kelly, F.J., Mudway, I., Blomberg, A., Frew, A., and Sandstrom, T., Lancet, 1999, vol. 354, pp. 482–483.CrossRefGoogle Scholar
  3. 3.
    Caramori, G. and Papi, A., Thorax, 2004, vol. 59, pp. 170–173.CrossRefGoogle Scholar
  4. 4.
    Greene, L.S., Nutrition, 1999, vol. 15, pp. 899–907.CrossRefGoogle Scholar
  5. 5.
    Dworski, R., Thorax, 2000, vol. 55(2), pp. 51–53.CrossRefGoogle Scholar
  6. 6.
    Men’shchikova, E.B. and Zenkov, N.K., Ter. Arkh., 1991, no. 11, pp. 85–87.Google Scholar
  7. 7.
    Beasley, R., Thomson, C., and Pearce, N., Clin. Exper. Allergy, 1991, vol. 21, pp. 157–159.CrossRefGoogle Scholar
  8. 8.
    Misso, N.L.A., Powers, K.A., Gillon, R.L., Stewart, G.A., and Thomson, P.J., Clin. Exper. Allergy, 1996, vol. 26, pp. 838–847.CrossRefGoogle Scholar
  9. 9.
    Burk, R.F., J. Nutr., 1989, vol. 119, pp. 1051–1054.Google Scholar
  10. 10.
    Weber, G.F., Maertens, P., and Meng, X.Z., Lancet, 1991, vol. 337(8755), pp. 1443–1444.CrossRefGoogle Scholar
  11. 11.
    Kiremidjian-Schumacher, L. and Roy, M., Z. Emahrungswiss, 1998, vol. 37(1), pp. 50–56.Google Scholar
  12. 12.
    Hogan, G.R., J. Toxicol. Environ. Health, 1998, vol. 53, pp. 113–119.CrossRefGoogle Scholar
  13. 13.
    Flohe, L., Med. Klin., 1997, vol. 92, pp. 5–7.Google Scholar
  14. 14.
    Shaw, R., Woodman, K., Crane, J., Moyes, C., Kennedy, J., and Pearce, N., N. Z. Med. J., 1994, vol. 107(987), pp. 387–391.Google Scholar
  15. 15.
    Girodon, F., Lombard, M., Galan, P., Brunet-Lecomte, P., Monget, A.L., Arnad, J., Preziosi, P., and Hercborg, S., Ann. Nutr. Metab., 1997, vol. 41, pp. 98–107.CrossRefGoogle Scholar
  16. 16.
    Johnson, M.A., and Porter, K.H., Nutr. Rev., 1997, vol. 55(11), pp. 400–404.CrossRefGoogle Scholar
  17. 17.
    Rayman, M.P., Lancet, 2000, vol. 356, pp. 233–241.CrossRefGoogle Scholar
  18. 18.
    Kumerova, A., Lece, A.G., Skesters, A.P., Orlikov, G.A., Seleznev, J.V., and Rainsford, K.D., Biol. Trace. Elem. Res., 2000, vol. 77, pp. 1–12.CrossRefGoogle Scholar
  19. 19.
    Peat, J.K., Eur. Respir. J., 1996, vol. 9, pp. 1545–1555.CrossRefGoogle Scholar
  20. 20.
    T. Veen, J., Sterk, P., and Bel, E., Clin. Exper. Allergy, vol. 30, pp. 16–33.Google Scholar
  21. 21.
    Semenova, G.N., Labor. Delo, 1991, no. 11, pp. 33–38.Google Scholar
  22. 22.
    Aebi, H., Methods Enzymol., 1984, vol. 105, pp. 121–126.Google Scholar
  23. 23.
    Alfthan, G., Anal. Chim. Acta, 1984, vol. 165, pp. 187–194.CrossRefGoogle Scholar
  24. 24.
    Paglia, D.E. and Valentine, W.N., J. Lab. Clin. Med., 1987, vol. 70, pp. 158–169.Google Scholar

Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • J. G. Voicehovska
    • 1
  • A. Shkesters
    • 2
  • G. A. Orlikov
    • 1
  • A. A. Silova
    • 2
  • N. J. Rusakova
    • 2
  • L. T. Larmane
    • 2
  • J. G. Karpov
    • 1
  • A. D. Ivanov
    • 1
  • E. Maulinsh
    • 3
  1. 1.Department of Internal DiseasesP. Stradina UniversityRigaLatvia
  2. 2.Laboratory of BiochemistryP. Stradina UniversityRigaLatvia
  3. 3.Allergology/Pulmonology CenterClinical University P. Stradina HospitalRigaLatvia

Personalised recommendations