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Effects of Nd3+ on Calcium-Dependent Processes in Isolated Rat Heart Mitochondria and Frog Heart Muscle

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Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Aims and scope

Abstract

The inotropic and chronotropic effects of neodymium ions (Nd3+) on the heart muscle of a frog Rana ridibunda and the influence of Nd3+ on respiration, swelling, and potential (∆Ψmito) of Ca2+-loaded rat heart mitochondria (RHM) were studied. It was found that Nd3+ reduced the amplitude and frequency of spontaneous heart contraction (Fmax); Nd3+ also prevented a short-term increase in Ca2+-induced basal respiration of mitochondria and their swelling in salt media, as well as a decrease of ∆Ψmito on the inner mitochondrial membrane (IMM). At the same time, Nd3+ slightly affected mitochondrial respiration in state 3 or in 2,4-dinitrophenol (DNP)-uncoupled state. These effects of Nd3+ may indicate that Nd3+ inhibits the mitochondrial permeability transition pore (MPTP) opening, which is formed in calcium loaded mitochondria. The data obtained are important for a better understanding of the mechanisms of action of rare earth elements on Ca2+-dependent processes in the myocardium of vertebrates.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 194223, St. Petersburg, Russia

    S. M. Korotkov, C. V. Sobol, I. V. Schemarova, V. V. Furaev, A. V. Novozhilov & V. P. Nesterov

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  1. S. M. Korotkov
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  2. C. V. Sobol
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  3. I. V. Schemarova
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  4. V. V. Furaev
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  5. A. V. Novozhilov
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  6. V. P. Nesterov
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Correspondence to S. M. Korotkov.

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Translated by E. Puchkov

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Korotkov, S.M., Sobol, C.V., Schemarova, I.V. et al. Effects of Nd3+ on Calcium-Dependent Processes in Isolated Rat Heart Mitochondria and Frog Heart Muscle. Biochem. Moscow Suppl. Ser. A 13, 161–167 (2019). https://doi.org/10.1134/S1990747819070018

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  • DOI: https://doi.org/10.1134/S1990747819070018

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