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Platelet Integrin αIIbβ3: Mechanisms of Activation and Clustering; Involvement into the Formation of the Thrombus Heterogeneous Structure

  • V. N. Kaneva
  • A. A. Martyanov
  • D. S. Morozova
  • M. A. PanteleevEmail author
  • A. N. Sveshnikova
REVIEW
  • 34 Downloads

Abstract

Glycoproteins IIb-IIIa (GPIIb-IIIa), also known as αIIbβ3 integrins, are key platelet adhesion receptors. These molecules are the most abundant (over 10 000 copies per cell) transmembrane receptors playing a crucial role in thrombus formation by promoting platelet aggregation. Integrins need to undergo activation and transit to high-affinity state for their ligands – fibrinogen, fibrin, and von Willebrand factor (VWF) – in order to form bonds between platelets. Activation of integrins is mediated by a set of various messengers through intracellular signalization. Integrins αIIbβ3, like other integrins, are capable of reverse signal transmission inside the cell, called “outside-in” signaling. Recent studies have shown heterogeneity of the thrombus structure and the existence of a stable and dense inner core and a fluid-like loose shell. Since platelet aggregation is provided by integrin-mediated interactions, one can suggest that it is the features of integrin activation and clustering that strongly influence the formation of thrombus architecture. This work is intent on systematizing recent data concerning activation and functioning of platelet integrins αIIbβ3 and searching for correlations between thrombus heterogeneity and the state of integrins on the platelets surface.

Keywords:

platelets integrin αIIbβ3 cell adhesion intracellular signaling 

Notes

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Copyright information

© Pleiades Publishing, Ltd. 2019

Authors and Affiliations

  • V. N. Kaneva
    • 1
    • 2
    • 3
  • A. A. Martyanov
    • 1
    • 2
    • 3
  • D. S. Morozova
    • 4
  • M. A. Panteleev
    • 1
    • 2
    • 3
    • 5
    Email author
  • A. N. Sveshnikova
    • 1
    • 2
    • 3
    • 6
  1. 1.Faculty of Physics, Moscow Lomonosov State UniversityMoscowRussia
  2. 2.National Medical Research Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry RogachevMoscowRussia
  3. 3.Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of SciencesMoscowRussia
  4. 4.Faculty of Medicine, Moscow Lomonosov State UniversityMoscowRussia
  5. 5.Faculty of Biological and Medical Physics, Moscow Institute of Physics and TechnologyDolgoprudnyiRussia
  6. 6.Department of Normal Physiology, Sechenov First Moscow State Medical UniversityMoscowRussia

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