Biology of dendritic cells

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Abstract

Dendritic cells (DC) play a key role in adaptive immune response. By virtue of their extremely wide distribution and high populational diversity, DC interact with almost all types of immune cells linking innate and adaptive immunity. Due to great diversity of receptors, DC recognize a lot of pathogenic microorganisms and namely DC are responsible for the subsequent immune response. Inflammation triggers maturation of DC, which manifests itself in intracellular rearrangement and in appearance of costimulating molecules (CD40, CD80 and CD86) on DC surface. DC capture and process antigens keeping high amount of immunogenic peptides which are then presented to naive lymphocytes and induce their differentiation into effector cells. Depending on pathogen type and cytokine microenvironment, DC induce polarization of immune responses. In the absence of proinflammatory factors DC induce tolerance. In addition, DC play a crucial role in T-lymphocyte selection and Treg formation. The basic traits of DC biology are reviewed.

Keywords

Dendritic Cell Major Histocompatibility Complex Class Supplement Series Immature Dendritic Cell Dritic Cell 

Abbreviations

Ag

antigen

APC

antigen-presenting cells

DC

dendritic cells

IL

interleukin

INF

interferon

LPS

lipopolysaccharide

NK

natural killer cells

NKT

natural killer T-lymphocytes

OVA

ovalbumin

pDC

Plasmacytoid dendritic cells

Treg

regulatory T-lymphocytes

TGF

transforming growth factor

TCR

T-cell receptor

TNF

tumor necrosis factor

ER

endoplasmic reticulum

TLR

Toll-like receptors

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© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Mechnikov Research Institute for Vaccines and SeraRussian Academy of Medical SciencesMoscowRussia

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