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Tandem repeats in the rodent genome and their mapping

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Abstract

Tandemly repeated sequences are unique to eukaryotes and make up tens of percent of the higher eukaryote genome. However, the evolution of this class of sequences is poorly studied. In our paper, 62 families of Mus musculus tandem repeats are analyzed by bioinformatic methods, while 7 of them are analyzed by fluorescence in situ hybridization. It is shown that the same tandem repeat sets occur together only in closely related species of mice. However, even in such species, we observe differences in localization on chromosomes and the number of individual tandem repeats. With increasing evolutionary distance, only some of the tandem repeat families remain common for different species. It is shown that the use of a combination of bioinformatics and molecular biology techniques is very promising for further studies of tandem repeat evolution.

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Abbreviations

periCEN:

pericentromeric region of chromosomes

satDNA:

satellite DNA

bp:

base pair

TR:

tandem repeats

CEN:

centromeric region of chromosomes

SRA:

sequence read archive

WGS:

whole genome shotgun

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Authors and Affiliations

  1. Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia

    D. I. Ostromyshenskii, I. S. Kuznetsova, A. S. Komissarov & O. I. Podgornaya

  2. Institute of Biology and Soil Sciences, Far East Branch, Russian Academy of Sciences, Vladivostok, 690022, Russia

    I. V. Kartavtseva

Authors
  1. D. I. Ostromyshenskii
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  2. I. S. Kuznetsova
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  3. A. S. Komissarov
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  4. I. V. Kartavtseva
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  5. O. I. Podgornaya
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Corresponding author

Correspondence to D. I. Ostromyshenskii.

Additional information

Original Russian Text © D.I. Ostromyshenskii, I.S. Kuznetsova, A.S. Komissarov, I.V. Kartavtseva, O.I. Podgornaya, 2015, published in Tsitologiya, 2015, Vol. 57, No. 2, pp. 102–110.

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Ostromyshenskii, D.I., Kuznetsova, I.S., Komissarov, A.S. et al. Tandem repeats in the rodent genome and their mapping. Cell Tiss. Biol. 9, 217–225 (2015). https://doi.org/10.1134/S1990519X15030116

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  • DOI: https://doi.org/10.1134/S1990519X15030116

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