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Rat heart structural and functional characteristics and gas exchange parameters after experimental myocardial infarction

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Abstract

Structural and functional changes in the heart and the parameters of gas exchange in rats were analyzed 6 months after initiation of myocardial infarction. With the aid of echocardiography, an increase was revealed of the terminal systolic and terminal diastolic sizes of the left heart ventricle in rats with chronic heart failure as compared with control by 78 and 30%, respectively. The volumes of the left ventricle in the systole and diastole were even greater—by five and two times, respectively. Dilation of the left ventricle cavity was accompanied by a thinning of the interventricular septum. As a result of structural changes of the left ventricle, its ability to function was significantly degraded. The shortening fraction in chronic heart failure decreased by 60%, while the output fraction decreased by 52%, compared with the corresponding parameters in control rats. Measurement of gas exchange showed that oxygen consumption in rats with chronic heart failure increased by almost 30%, while production of carbon dioxide by more than 40%. The respiration coefficient in rats with chronic heart failure amounted to 0.85, which indicates a significant increase of contribution of carbohydrates as energy substrates in metabolism of myocardium.

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Abbreviations

MI:

myocardial infarction

TDS:

terminal diastolic size of LV

TSS:

terminal systolic size of LV

LV:

left ventricle

LA:

left atrium

IVS:

interventricular septum

CO:

cardiac output

SV:

systolic volume

EF:

ejection fraction

SF:

shortening fraction

CHF:

chronic heart failure

HR:

heart contraction rate

EchoCG:

echocardiographic study

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Authors and Affiliations

  1. Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia

    E. V. Baidyuk, G. A. Sakuta & B. N. Kudryavtsev

  2. St. Petersburg State University of Analytical Instrumentation, St. Petersburg, Russia

    L. P. Kislyakova & Yu. Ya. Kislyakov

  3. Chemical Pharmaceutical Academy, St. Petersburg, Russia

    S. V. Okovityi

Authors
  1. E. V. Baidyuk
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  2. G. A. Sakuta
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  3. L. P. Kislyakova
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  4. Yu. Ya. Kislyakov
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  5. S. V. Okovityi
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  6. B. N. Kudryavtsev
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Correspondence to E. V. Baidyuk.

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Original Russian Text © E.V. Baidyuk, G.A. Sakuta, L.P. Kislyakova, Yu.Ya. Kislyakov, S.V. Okovityi, B.N. Kudryavtsev, 2014, published in Tsitologiya, 2014, Vol. 56, No. 10, pp. 735–740.

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Baidyuk, E.V., Sakuta, G.A., Kislyakova, L.P. et al. Rat heart structural and functional characteristics and gas exchange parameters after experimental myocardial infarction. Cell Tiss. Biol. 9, 24–29 (2015). https://doi.org/10.1134/S1990519X15010022

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  • DOI: https://doi.org/10.1134/S1990519X15010022

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